Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ashley Eheim"'
Autor:
Clara Lemos, Luise Schulze, Joerg Weiske, Hanna Meyer, Nico Braeuer, Naomi Barak, Uwe Eberspächer, Nicolas Werbeck, Carlo Stresemann, Martin Lange, Ralf Lesche, Nina Zablowsky, Katrin Juenemann, Atanas Kamburov, Laura Martina Luh, Thomas Markus Leissing, Jeremie Mortier, Michael Steckel, Holger Steuber, Knut Eis, Ashley Eheim, Patrick Steigemann
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101517- (2020)
Summary: Structural mutants of p53 induce global p53 protein destabilization and misfolding, followed by p53 protein aggregation. First evidence indicates that p53 can be part of protein condensates and that p53 aggregation potentially transitions th
Externí odkaz:
https://doaj.org/article/a212af021eff409c84704cd1ec1f0308
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
The lactate transporter SLC16A1/monocarboxylate transporter 1 (MCT1) plays a central role in tumor cell energy homeostasis. In a cell-based screen, we identified a novel class of MCT1 inhibitors, including BAY-8002, which potently suppress bidirectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecc176275426db1e8e7d752f623ce531
https://doi.org/10.1158/1535-7163.c.6537978.v1
https://doi.org/10.1158/1535-7163.c.6537978.v1
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplementary Methods: Synthesis and characterization of BAY-8002; Tritium labeling of AZD3965 and BAY-8002; MCT1 and MCT4 14C-lactate uptake measurements in the X. laevis oocytes expression System
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9c449390e8d6d58b8fd14c10da3442
https://doi.org/10.1158/1535-7163.22505181
https://doi.org/10.1158/1535-7163.22505181
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplemental Table S1: Selectivity profile of BAY-8002. Supplemental Table S2: Summary table of functional and proliferation IC50 data for BAY-8002 and AZD3965. Supplemental Table S3: Responses to BAY-8002 and AZD3965 of cell lines with acquired resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4b47918c194f9c7b520dda50e82cba
https://doi.org/10.1158/1535-7163.22505184.v1
https://doi.org/10.1158/1535-7163.22505184.v1
Autor:
Andrea Hägebarth, Marcus Bauser, Holger Siebeneicher, Atanas Kamburov, Ralf Lesche, Claudia Merz, Joern Toedling, Carmen Richter, Roland Neuhaus, Luisella Toschi, Ashley Eheim, Wolfgang Schwede, Andreas Schlicker, Sylvia Grünewald, Charlotte Kopitz, Eckhard Bender, Maria Quanz
Supplemental Figure S1: A, SLC16A1 (MCT1), SLC16A7 (MCT2), SLC16A8 (MCT3) and SLC16A3 (MCT4) mRNA expression levels and Effects of BAY-8002 on lactate Export and ECAR. Supplemental Figure S2: Binding affinity of the two MCT1 inhibitors BAY-8002 and A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f37e408a23840755a8e7e27d10ad6b
https://doi.org/10.1158/1535-7163.22505187
https://doi.org/10.1158/1535-7163.22505187
Autor:
Krzysztof Brzezinka, Ralf Lesche, Michael Steckel, Andrea Haegebarth, Ashley Eheim, Carlo Stresemann, Ekaterina Nevedomskaya
Publikováno v:
Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2019)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Introduction The chromosomal rearrangements of the mixed-lineage leukemia gene MLL (KMT2A) have been extensively characterized as a potent oncogenic driver in leukemia. For its oncogenic function, most MLL-fusion proteins exploit the multienzyme supe
Autor:
Stefan Gradl, Sooncheol Lee, Martin Lange, Xiaoyun Wu, Silvia Goldoni, Timothy Lewis, Charlotte Kopitz, Colin Garvie, Philip Lienau, Stephanie Hoyt, Henrik Seidel, Stephan Kaulfuss, Manuel Ellermann, Luc de Waal, Adrian Tersteegen, Sven Golfier, Detlev Suelzle, Christa Hegele-Hartung, James Carr, Frederick Brookfield, Michael Bruening, Melanie Berthold, Thibaud Jourdan, Monica Schenone, Galen Gao, Joseph McGaunn, Antje Wengner, Elisa Aquilanti, Franziska Siegel, Marine Garrido, Annette Walter, Isabelle Genvresse, Andrew Cherniack, Stuart Schreiber, Knut Eis, Ashley Eheim, Matthew Meyerson, Heidi Greulich
Publikováno v:
Cancer Research. 82:ND04-ND04
Velcrin compounds are a class of small molecules that induce complex formation between PDE3A and SLFN12, killing cancer cells that express elevated levels of these two proteins by a mechanism independent of PDE3A enzymatic inhibition. Instead, PDE3A
Autor:
Silvia Goldoni, Martin Lange, Charlotte Kopitz, Stefan Kaulfuss, Sven Golfier, Adrian Tersteegen, Stefanie Bunse, Melanie Berthold, Thibaud Jordan, Philip Lienau, Franziska Siegel, Annette Walter, Henrik Seidel, Elisa Aquilanti, Andrew Baker, Xiaoyun Wu, Sooncheol Lee, Stefan Gradl, Emmanuelle di Tomaso, Matthew Meyerson, Knut Eis, Ashley Eheim, Heidi Greulich
Publikováno v:
Cancer Research. 82:2663-2663
BAY 2666605, co-developed by the Broad Institute and Bayer Pharmaceuticals, is a selective and potent molecular glue, part of a family of small molecules recently baptized as ‘velcrins’, that induces complex formation between phosphodiesterase 3A
Autor:
Steven M. Corsello, Huajia Zhang, Rajesha Rupaimoole, Volker K. Schulze, Clara Lemos, Kasia B. Handing, Douglas L. Orsi, Mrinal Shekhar, Ulrike Sack, Sven Christian, Wilhelm Bone, Ranad Humeidi, William Colgan, Stephanie Hoyt, Andrew Cherniack, Jens Schroder, Stefan Kaulfuss, Krzysztof Brzezinka, Oliver von Ahsen, Anne Mengel, Roman C. Hillig, Detlev Suelzle, Jeremie Mortier, Caitlin Harrington, Rohith Nagari, Justyna Wierzbinska, Derek Chiang, Georg Beckmann, Meagan Olive, Namrata Udeshi, Annie Apffel, Steven Carr, Philip Lienau, Christian Lechner, Ulf Boemer, Alisha Caliman, David McKinney, Florence Wagner, Dominik Mumberg, Marcus Bauser, Andrea Haegebarth, Knut Eis, Ashley Eheim, Todd R. Golub
Publikováno v:
Cancer Research. 82:3588-3588
CSNK1A1 is a serine/threonine kinase involved in multiple cellular processes, including cell division, beta catenin signaling, and TP53 activation. Inhibition of CSNK1A1 has previously been validated as a therapeutic strategy in hematologic malignanc
Autor:
Laura Doherty, Tenzin Sangpo, Peter Tsvetkov, John Davis, Navid Dianati, Wolfgang Schwede, Katja Zimmermann, Laura Evans, Aldo Amatucci, Henrik Seidel, Atanas Kamburov, Gizem Akcay, Todd Golub, Ashley Eheim, Nils Burkhardt, Knut Eis, Sven Christian, Matt Rees, Jennifer Roth
Publikováno v:
Cancer Research. 82:2682-2682
To identify novel therapeutic targets, we utilize the PRISM platform, a multiplexed cell line viability technology of 500 solid tumor cell lines and correlate responses to functional genomic and baseline genetic data. We describe ESD0140656, a small