Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ashley E. Keller"'
Autor:
Ami Patel, Antonio DiGiandomenico, Ashley E. Keller, Trevor R. F. Smith, Daniel H. Park, Stephanie Ramos, Katherine Schultheis, Sarah T. C. Elliott, Janess Mendoza, Kate E. Broderick, Megan C. Wise, Jian Yan, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kar Muthumani, Laurent Humeau, Lily I. Cheng, Leslie Wachter-Rosati, C. Kendall Stover, Niranjan Y. Sardesai, David B. Weiner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
DNA-delivered monoclonal antibodies (DMAbs) can be produced by muscle cells in vivo, potentially allowing prevention or treatment of infectious diseases. Here, the authors show that two DMAbs targeting Pseudomonas aeruginosa proteins confer protectio
Externí odkaz:
https://doaj.org/article/5cc6f71f1078455d97d037b4f8457a6b
Autor:
Ajitha, Thanabalasuriar, Abby J, Chiang, Christopher, Morehouse, Margarita, Camara, Shonda, Hawkins, Ashley E, Keller, Adem C, Koksal, Carolina S, Caceres, Aaron A, Berlin, Nicholas, Holoweckyj, Virginia N, Takahashi, Lily, Cheng, Melissa, de Los Reyes, Mark, Pelletier, Andriani C, Patera, Bret, Sellman, Sonja, Hess, Marcello, Marelli, Chelsea C, Boo, Taylor S, Cohen, Antonio, DiGiandomenico
Publikováno v:
Science Advances
Neutrophils abandon infection control during wound repair.
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
The underlying mechanisms contributing to injury-induced infection susceptibility remain poorly understood. Here, we describe a rapid increase in neutrophil cell numbers in the lungs fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dadb20c85d74981819d8a619237afbcb
https://pubmed.ncbi.nlm.nih.gov/33674305
https://pubmed.ncbi.nlm.nih.gov/33674305
Autor:
Charles K. Stover, George Wilson, Ajitha Thanabalasuriar, Antonio DiGiandomenico, Bas G.J. Surewaard, Paul Kubes, Michelle Elizabeth Willson, Arpan Sharma Neupane, Ashley E. Keller, Bret R. Sellman, Paul Warrener
Publikováno v:
Journal of Clinical Investigation. 127:2249-2261
Pseudomonas aeruginosa is a major cause of severe infections that lead to bacteremia and high patient mortality. P. aeruginosa has evolved numerous evasion and subversion mechanisms that work in concert to overcome immune recognition and effector fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be5275ac73559437de02a369ff3003c
https://doi.org/10.1172/jci89652
https://doi.org/10.1172/jci89652
Autor:
Matthias Amrein, Moritz Peiseler, Agostina Carestia, Margaret M. Kelly, Arpan Sharma Neupane, Ashley E. Keller, Fernanda Vargas E Silva Castanheira, Paul Kubes, Craig N. Jenne, Antonio DiGiandomenico, Ajitha Thanabalasuriar, Michelle Elizabeth Willson, Andrew Chojnacki, Christopher Morehouse
Publikováno v:
Cell. 183(1)
Summary During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar macrophages (AMs), which favors alveoli devoid of AMs. If AMs, like m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce3cbf626f12b5820d4691e6ec74de0
https://pubmed.ncbi.nlm.nih.gov/32888431
https://pubmed.ncbi.nlm.nih.gov/32888431
Autor:
Antonio DiGiandomenico, E Song, C. K. Stover, David E. Tabor, Robert E. McLaughlin, Alexey Ruzin, Y Qi, Li Yu, Paul Warrener, Ashley E. Keller, Kim Rosenthal, Mark T. Esser, Vaheh Oganesyan
Publikováno v:
The Journal of Infectious Diseases.
Background Bispecific antibody MEDI3902, targeting the Pseudomonas aeruginosa type 3 secretion system (PcrV) and Psl exopolysaccharide, is currently in phase 2b development for prevention of nosocomial pneumonia in patients undergoing mechanical vent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c2a0ac92c937936424b5deebfc0f044
https://doi.org/10.1093/infdis/jiy438
https://doi.org/10.1093/infdis/jiy438
Autor:
M. Margarita Camara, C. Kendall Stover, Wei Zhao, Joshua T. Thaden, Antonio DiGiandomenico, Linda G. Otterson, Norah J. Shire, Vance G. Fowler, Caitlin M. Guenther, Mike Huband, Paul Warrener, Ashley E. Keller
Publikováno v:
Journal of Infectious Diseases. 213:640-648
Background. The type 3 secretion protein PcrV and Psl exopolysaccharide are promising therapeutic antibody targets against Pseudomonas aeruginosa. We examined P. aeruginosa bloodstream infection (BSI) isolates for the ability to express PcrV and Psl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8c16c68d847dab765137f9adf3040
https://doi.org/10.1093/infdis/jiv436
https://doi.org/10.1093/infdis/jiv436
Autor:
Antonio DiGiandomenico, Karuppiah Muthumani, Ashley E. Keller, Niranjan Y. Sardesai, Leslie Wachter-Rosati, Lily Cheng, Janess M. Mendoza, David B. Weiner, Laurent Humeau, Stephanie Ramos, C. Kendall Stover, Daniel H. Park, Jingjing Jiang, Seleeke Flingai, Amir S. Khan, Kate E. Broderick, Sarah T. C. Elliott, Jian Yan, Ami Patel, Katherine Schultheis, Megan C. Wise, Trevor R.F. Smith
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The impact of broad-spectrum antibiotics on antimicrobial resistance and disruption of the beneficial microbiome compels the urgent investigation of bacteria-specific approaches such as antibody-based strategies. Among these, DNA-delivered monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f4071ceae2d261e1e4044edc3eb743
http://europepmc.org/articles/PMC5608701
http://europepmc.org/articles/PMC5608701
Autor:
Antonio DiGiandomenico, C. Anude, S.O. Ali, Filip Dubovsky, Yuling Wu, Hasan S. Jafri, Li Yu, Terramika Bellamy, Ashley E. Keller, Judith Falloon, Gabriel Robbie, Kathryn Shoemaker, M. Hernandez-Illas, Xiang-Qing Yu
Publikováno v:
Clinical Microbiology and Infection. 25:629.e1-629.e6
Objectives MEDI3902 is a bivalent, bispecific human immunoglobulin G1κ monoclonal antibody that binds to both the Pseudomonas aeruginosa PcrV protein involved in host cell cytotoxicity and the Psl exopolysaccharide involved in P. aeruginosa coloniza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f860b0e5e8a256c2671d0625b1a43ff
https://doi.org/10.1016/j.cmi.2018.08.004
https://doi.org/10.1016/j.cmi.2018.08.004
Autor:
Brittney N V Scott, Michelle Elizabeth Willson, Ashley E. Keller, Paul Kubes, Lily Cheng, Juha Tapio Korhonen, Moritz Peiseler, Paul Warrener, Zhutian Zeng, Mihaela Gadjeva, Elizabeth Ashley Dozier, Ajitha Thanabalasuriar, Antonio DiGiandomenico, Bas G.J. Surewaard, C. Kendall Stover
Publikováno v:
Cell Host Microbe
Summary Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b024674445d885f611cd5135c249af81
https://doi.org/10.1016/j.chom.2019.02.007
https://doi.org/10.1016/j.chom.2019.02.007
Autor:
Taylor S. Cohen, Binh An Diep, Ashley E. Keller, Jamese J. Hilliard, Omari Jones-Nelson, Mark Pelletier, Antonio DiGiandomenico, Melissa Hamilton, C. Kendall Stover, Lily Cheng, Qun Wang, Vien T. M. Le, JoAnn Suzich, Bret R. Sellman, Christine Tkaczyk, Terrence O'Day
Publikováno v:
Science Translational Medicine. 8
Broad-spectrum antibiotic use may adversely affect a patient's beneficial microbiome and fuel cross-species spread of drug resistance. Although alternative pathogen-specific approaches are rationally justified, a major concern for this precision medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa43ee213dabe4ed9a9210fd8608d1a3
https://doi.org/10.1126/scitranslmed.aad9922
https://doi.org/10.1126/scitranslmed.aad9922