Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ashley E. Frakes"'
Autor:
Melissa G. Metcalf, Samira Monshietehadi, Arushi Sahay, Jenni Durieux, Ashley E. Frakes, Martina Velichkovska, Cesar Mena, Amelia Farinas, Melissa Sanchez, Andrew Dillin
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109354- (2024)
Summary: Glia are the protectors of the nervous system, providing neurons with support and protection from cytotoxic insults. We previously discovered that four astrocyte-like glia can regulate organismal proteostasis and longevity in C. elegans. Exp
Externí odkaz:
https://doaj.org/article/b360eb2c1dd745f7b1d0d5324895fee8
Autor:
Catherine P. Ward, Lucy Peng, Samuel Yuen, Michael Chang, Rozalina Karapetyan, Edna Nyangau, Hussein Mohammed, Hector Palacios, Naveed Ziari, Larry K. Joe, Ashley E. Frakes, Mohamad Dandan, Andrew Dillin, Marc K. Hellerstein
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1073 (2022)
The unfolded protein response in the endoplasmic reticulum (UPRER) is involved in a number of metabolic diseases. Here, we characterize UPRER-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometric analysis
Externí odkaz:
https://doaj.org/article/97cbc8ef4d9e4b08b6dba8b83e70e7d4
Autor:
Holly K. Gildea, Phillip A. Frankino, Sarah U. Tronnes, Corinne L. Pender, Jenni Durieux, Julian G. Dishart, Hyun Ok Choi, Tayla D. Hunter, Shannon S. Cheung, Ashley E. Frakes, Edward Sukarto, Kevin Wickham, Andrew Dillin
Publikováno v:
Science Advances. 8
Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can
Autor:
Holly K, Gildea, Phillip A, Frankino, Sarah U, Tronnes, Corinne L, Pender, Jenni, Durieux, Julian G, Dishart, Hyun Ok, Choi, Tayla D, Hunter, Shannon S, Cheung, Ashley E, Frakes, Edward, Sukarto, Kevin, Wickham, Andrew, Dillin
Publikováno v:
Science advances. 8(49)
Aging organisms lose the ability to induce stress responses, becoming vulnerable to protein toxicity and tissue damage. Neurons can signal to peripheral tissues to induce protective organelle-specific stress responses. Recent work shows that glia can
Autor:
Holly K. Gildea, Melissa G. Metcalf, Ashley E. Frakes, Sarah U. Tronnes, Jenni Durieux, Andrew Dillin, Samira Monshietehadi, Nazineen Kandahari, Raz Bar-Ziv
Publikováno v:
Science
Science (New York, N.Y.), vol 367, iss 6476
Science (New York, N.Y.), vol 367, iss 6476
Taking the stress out of life In the model organism Caenorhabditis elegans , a roundworm, it has been shown that neurons can communicate proteostasis to the periphery to affect aging. Frakes et al. have now identified astrocytelike glial cells that a
Autor:
Catherine P. Ward, Lucy Peng, Samuel Yuen, Michael Chang, Rozalina Karapetyan, Edna Nyangau, Hussein Mohammed, Hector Palacios, Naveed Ziari, Larry K. Joe, Ashley E. Frakes, Mohamad Dandan, Andrew Dillin, Marc K. Hellerstein
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1073
International Journal of Molecular Sciences, Vol 23, Iss 1073, p 1073 (2022)
International Journal of Molecular Sciences, Vol 23, Iss 1073, p 1073 (2022)
The unfolded protein response in the endoplasmic reticulum (UPRER) is involved in a number of metabolic diseases. Here, we characterize UPRER-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometric analysis
Autor:
Hussein Mohammed, Andrew Dillin, Catherine Schneider, Hector Palacios, Peng L, Marc K. Hellerstein, Yuen S, Ashley E. Frakes, Edna Nyangau, Ziari N, Halstead J
Age is a risk factor for numerous diseases, including neurodegenerative diseases, cancers, and diabetes. Loss of protein homeostasis is a central hallmark of aging. Activation of the endoplasmic reticulum unfolded protein response (UPRER) includes ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27fcb85b949dbe000470bc916f7f2931
https://doi.org/10.1101/2021.04.14.439896
https://doi.org/10.1101/2021.04.14.439896
Autor:
Ashley E. Frakes, Michael Chang, Rozalina Karapetyan, Lucy Peng, Andrew Dillin, Hector Palacios, Samuel Yuen, Naveed Ziari, Edna Nyangau, Larry Joe, Catherine Schneider, Marc K. Hellerstein, Hussein Mohammed
The unfolded protein response in the endoplasmic reticulum (UPRER) is involved in a number of metabolic diseases, including non-alcoholic fatty liver disease. Here, we characterize the UPRER induced metabolic changes in mouse liver through in vivo me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e042146318b1fd30fd47d855903fae8d
https://doi.org/10.1101/2020.10.29.360073
https://doi.org/10.1101/2020.10.29.360073
Autor:
Raz, Bar-Ziv, Ashley E, Frakes, Ryo, Higuchi-Sanabria, Theodore, Bolas, Phillip A, Frankino, Holly K, Gildea, Melissa G, Metcalf, Andrew, Dillin
Publikováno v:
J Vis Exp
Organisms are often exposed to fluctuating environments and changes in intracellular homeostasis, which can have detrimental effects on their proteome and physiology. Thus, organisms have evolved targeted and specific stress responses dedicated to re
Autor:
Ashley E. Frakes, Andrew Dillin
Publikováno v:
Molecular Cell. 66:761-771
Life is stressful. Organisms are repeatedly exposed to stressors that disrupt protein homeostasis (proteostasis), resulting in protein misfolding and aggregation. To sense and respond to proteotoxic perturbations, cells have evolved compartment-speci