Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Ashley E Webb"'
Autor:
Doudou Yu, Manlin Li, Guanjie Linghu, Yihuan Hu, Kaitlyn H. Hajdarovic, An Wang, Ritambhara Singh, Ashley E. Webb
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113500- (2023)
Summary: Aging is a major risk factor for many diseases. Accurate methods for predicting age in specific cell types are essential to understand the heterogeneity of aging and to assess rejuvenation strategies. However, classifying organismal age at s
Externí odkaz:
https://doaj.org/article/99137b454a25496582a280c8e031c351
Autor:
Nelli S. Lakis, Alexander S. Brodsky, Galina Karashchuk, Amanda J. Audesse, Dongfang Yang, Ashlee Sturtevant, Kara Lombardo, Ian Y. Wong, Ashley E. Webb, Douglas C. Anthony
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract A growing body of evidence supports the presence of a population of cells in glioblastoma (GBM) with a stem cell-like phenotype which shares certain biological markers with adult neural stem cells, including expression of SOX2, CD133 (PROM1)
Externí odkaz:
https://doaj.org/article/d5691a8a61b44c2b926561532afe4f88
Autor:
Amanda J. Audesse, Galina Karashchuk, Zachary A. Gardell, Nelli S. Lakis, Sun Y. Maybury‐Lewis, Abigail K. Brown, Dena S. Leeman, Yee Voan Teo, Nicola Neretti, Douglas C. Anthony, Alexander S. Brodsky, Ashley E. Webb
Publikováno v:
Aging and Cancer, Vol 2, Iss 4, Pp 137-159 (2021)
Abstract Background Glioblastoma (GBM) is an aggressive, age‐associated malignant glioma that contains populations of cancer stem cells. These glioma stem cells (GSCs) evade therapeutic interventions and repopulate tumors due to their existence in
Externí odkaz:
https://doaj.org/article/dfb2b7f31be3409ab6907814e72b7ff3
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 15 (2021)
Stress is well-known to contribute to the development of many psychiatric illnesses including alcohol and substance use disorder (AUD and SUD). The deleterious effects of stress have also been implicated in the acceleration of biological age, and age
Externí odkaz:
https://doaj.org/article/ffc762c6607344c09d06fbe13927e788
Publikováno v:
Trends in Neurosciences. 45:942-954
The hypothalamus is a brain region that integrates signals from the periphery and the environment to maintain organismal homeostasis. To do so, specialized hypothalamic neuropeptidergic neurons control a range of processes, such as sleep, feeding, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7415ad77250078c04216987f9ca94991
https://doi.org/10.1016/j.tins.2022.10.004
https://doi.org/10.1016/j.tins.2022.10.004
Autor:
Kaitlyn H. Hajdarovic, Doudou Yu, Lexi-Amber Hassell, Shane A. Evans, Sarah Packer, Nicola Neretti, Ashley E. Webb
Publikováno v:
Nat Aging
Alterations in metabolism, sleep patterns, body composition and hormone status are all key features of aging. While the hypothalamus is a well-conserved brain region that controls these homeostatic and survival-related behaviors, little is known abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb4d3231278c65c81efda651ed83a55
https://doi.org/10.1038/s43587-022-00246-4
https://doi.org/10.1038/s43587-022-00246-4
Autor:
Amanda J Audesse, Shleshma Dhakal, Lexi-Amber Hassell, Zachary Gardell, Yuliya Nemtsova, Ashley E Webb
Publikováno v:
PLoS Genetics, Vol 15, Iss 4, p e1008097 (2019)
Maintenance of a healthy proteome is essential for cellular homeostasis and loss of proteostasis is associated with tissue dysfunction and neurodegenerative disease. The mechanisms that support proteostasis in healthy cells and how they become defect
Externí odkaz:
https://doaj.org/article/fc3e45a40a744edcad46e21a8f4a8f5e
Autor:
Amanda J Audesse, Ashley E Webb
Publikováno v:
Journal of Experimental Neuroscience, Vol 12 (2018)
Adult neurogenesis supports cognitive and sensory functions in mammals and is significantly reduced with age. Quiescent neural stem cells are the source of new neurons in the adult brain and emerging evidence suggests that the failure of these cells
Externí odkaz:
https://doaj.org/article/420fa8a5d6354c2694f04b90fada7dcf
Publikováno v:
Aging. 14
Compositional and transcriptional changes in the hematopoietic system have been used as biomarkers of immunosenescence and aging. Here, we use single-cell RNA-sequencing to study the aging peripheral blood in mice and characterize the changes in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac264b6629980d984ec644347ac9caf
https://pubmed.ncbi.nlm.nih.gov/36622281
https://pubmed.ncbi.nlm.nih.gov/36622281
Publikováno v:
Stem Cell Reports, Vol 2, Iss 4, Pp 414-426 (2014)
Skeletal muscle stem cells, or “satellite cells” (SCs), are required for the regeneration of damaged muscle tissue. Although SCs self-renew during regeneration, the mechanisms that govern SC re-entry into quiescence remain elusive. We show that F
Externí odkaz:
https://doaj.org/article/27b98dc7c52c42c080210ceed5defb5b