Výsledky vyhledávání - "Ashley E Mathews"

OR05-01 Small Heterodimer Partner Modulates Antigen Presenting Myeloid Cells to Impair Regulatory T Cell Expansion, Promoting Anti-Tumor Immunity in Models of Breast Cancer

Autor: Sayyed Hamed Shahoei, Madeline A. Henn, Erik R. Nelson, Varsha Vembar, Liqian Ma, Adam T Nelson, Ashley E Mathews, Yu Wang, Anna Vardanyan, Joy J. Chen, Lionel Apetoh

Publikováno v: Journal of the Endocrine Society

Immune checkpoint blockade has had underwhelming responses in breast cancer, in part due to the highly immune suppressive microenvironment. As a result, breast cancer continues to be the second most common cancer-related mortality amongst women, prov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4b7b42da5dd599cb0d33ff957a71a5
https://doi.org/10.1210/jendso/bvaa046.1056

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Abstract A93: Macrophage-expressed small heterodimer partner impairs expansion of regulatory T cells and enhances immune checkpoint inhibition

Autor: Adam T Nelson, Varsha Vembar, Liqian Ma, Lionel Apetoh, Madeline A. Henn, Erik R. Nelson, Ashley E Mathews, Joy J. Chen, Sayyed Hamed Shahoei

Publikováno v: Cancer Immunology Research. 8:A93-A93

Breast cancer continues to be the second most common cancer-related mortality among women, providing strong rationale for the development of new therapeutic approaches. Cholesterol and its metabolism have been implicated in the progression of breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13e1a44b131c00319f8bf02650159f27
https://doi.org/10.1158/2326-6074.tumimm19-a93

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Abstract P6-05-01: The small heterodimer partner in macrophages reduces expansion of regulatory T cells and enhances immune checkpoint inhibition in breast cancer

Autor: Erik R. Nelson, Lionel Apetoh, Ashley E Mathews, Madeline A. Henn, Adam T Nelson, Varsha Vembar, Sayyed Hamed Shahoei, Liqian Ma, Joy J. Chen

Publikováno v: Cancer Research. 80:P6-05

It has become clear that cholesterol metabolism and homeostasis play significant roles in the progression of breast cancer. Specifically, elevated circulating cholesterol is a poor prognostic, while patients taking cholesterol-lowering drugs such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c2515c34fcc7c701c0ecce89abd6c95
https://doi.org/10.1158/1538-7445.sabcs19-p6-05-01

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