Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ashley E Ciecko"'
Autor:
Susanne M. Cabrera, Alison T. Coren, Tarun Pant, Ashley E. Ciecko, Shuang Jia, Mark F. Roethle, Pippa M. Simpson, Samantha N. Atkinson, Nita H. Salzman, Yi-Guang Chen, Martin J. Hessner
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The incidence of type 1 diabetes (T1D) has increased, coinciding with lifestyle changes that have likely altered the gut microbiota. Dysbiosis, gut barrier dysfunction, and elevated systemic inflammation consistent with microbial antigen exp
Externí odkaz:
https://doaj.org/article/ad250eba8213477aa74556a077af8614
Autor:
Pinar Sargin, Mark F. Roethle, Shuang Jia, Tarun Pant, Ashley E. Ciecko, Samantha N. Atkinson, Nita H. Salzman, Ru-Jeng Teng, Yi-Guang Chen, Susanne M. Cabrera, Martin J. Hessner
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. Since Lactiplantibacillus plantarum 299 v (Lp299v) supplementation improves g
Externí odkaz:
https://doaj.org/article/04e49acff871446096d9b0058aa801e5
Autor:
Ashley E. Ciecko, Yu Wang, Stephanie Harleston, Amber Drewek, David V. Serreze, Aron M. Geurts, Chien-Wei Lin, Yi-Guang Chen
Publikováno v:
The Journal of Immunology. 210:935-946
IL-21 is essential for type 1 diabetes (T1D) development in the NOD mouse model. IL-21–expressing CD4 T cells are present in pancreatic islets where they contribute to T1D progression. However, little is known about their phenotype and differentiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93e31d5316f2759df4584955ec36c8c1
https://doi.org/10.4049/jimmunol.2200712
https://doi.org/10.4049/jimmunol.2200712
Autor:
Ashley E. Ciecko, Bardees Foda, Jennifer Y. Barr, Sheela Ramanathan, Mark A. Atkinson, David V. Serreze, Aron M. Geurts, Scott M. Lieberman, Yi-Guang Chen
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3073-3086.e5 (2019)
Summary: Human genetic studies implicate interleukin-27 (IL-27) in the pathogenesis of type 1 diabetes (T1D), but the underlying mechanisms remain largely unexplored. To further define the role of IL-27 in T1D, we generated non-obese diabetic (NOD) m
Externí odkaz:
https://doaj.org/article/3fc24c0010584feaa74f430e920e1248
Autor:
Pinar Sargin, Mark F. Roethle, Shuang Jia, Tarun Pant, Ashley E. Ciecko, Samantha N. Atkinson, Nita H. Salzman, Ru-Jeng Teng, Yi-Guang Chen, Susanne M. Cabrera, Martin J. Hessner
Publikováno v:
Gut microbes. 14(1)
The increasing incidence of Type 1 diabetes has coincided with the emergence of the low-fiber, high-gluten Western diet and other environmental factors linked to dysbiosis. SinceiLactiplantibacillus plantarum/i299 v (Lp299v) supplementation improves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365914839f4faee0f23b1b1c87deff3e
https://pubmed.ncbi.nlm.nih.gov/36261888
https://pubmed.ncbi.nlm.nih.gov/36261888
Autor:
David V. Serreze, Bardees M. Foda, Aron M. Geurts, Yi-Guang Chen, William M. Ridgway, Ashley E. Ciecko
Publikováno v:
The Journal of Immunology. 204:2887-2899
CD137 modulates type 1 diabetes (T1D) progression in NOD mice. We previously showed that CD137 expression in CD4 T cells inhibits T1D, but its expression in CD8 T cells promotes disease development by intrinsically enhancing the accumulation of β-ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::323d9219a81425b10936efc4ad064dd2
https://doi.org/10.4049/jimmunol.1900485
https://doi.org/10.4049/jimmunol.1900485
Autor:
Moujtaba Y Kasmani, Ashley E Ciecko, Ashley K Brown, Galina Petrova, Jack Gorski, Yi-Guang Chen, Weiguo Cui
Publikováno v:
Life science alliance. 5(10)
Type 1 diabetes (T1D) is an autoimmune disorder defined by CD8 T cell–mediated destruction of pancreatic β cells. We have previously shown that diabetogenic CD8 T cells in the islets of non-obese diabetic mice are phenotypically heterogeneous, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81bd3f52c53c2876fa94629778991a5
https://pubmed.ncbi.nlm.nih.gov/35667687
https://pubmed.ncbi.nlm.nih.gov/35667687
Autor:
Bardees M. Foda, William R. Drobyski, Moujtaba Y. Kasmani, Galina Petrova, Weiguo Cui, Robert K. Burns, David M. Schauder, Ashley E. Ciecko, Chien-Wei Lin, Yi-Guang Chen
Publikováno v:
J Immunol
In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests that the effector activity of β-cell autoreactive CD8 T cells needs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a2a6fdca413dd1140960dffa27ea77
https://europepmc.org/articles/PMC8492517/
https://europepmc.org/articles/PMC8492517/
Autor:
Scott M. Lieberman, Shamim Khaja, Michael Grzybowski, Aron M. Geurts, Yi-Guang Chen, Ashley E. Ciecko
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Recent advances in genetic analyses have significantly refined human type 1 diabetes (T1D) associated loci. The goal of such effort is to identify the causal genes and have a complete understanding of the molecular pathways that independently or inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aab31b6917400defa313a62f2667d2c
http://europepmc.org/articles/PMC7374577
http://europepmc.org/articles/PMC7374577
Autor:
Stefan J. Pietrzak, Hugo Lee, Feyza Engin, Shreyash Sonthalia, Yong-Syu Lee, Hülya Zeynep Oktay, Yi-Guang Chen, Quincy Eckert Harenda, Sunduz Keles, Sierra Schreiber, Yian Liao, Ashley E. Ciecko, Rupa Sridharan
Publikováno v:
Cell Metab
Summary Immune-mediated destruction of insulin-producing β cells causes type 1 diabetes (T1D). However, how β cells participate in their own destruction during the disease process is poorly understood. Here, we report that modulating the unfolded p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e550599bbf290c20da7384dd09a2efe6
https://pubmed.ncbi.nlm.nih.gov/32220307
https://pubmed.ncbi.nlm.nih.gov/32220307