Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ashley E, Lepack"'
Autor:
Amni Al-Kachak, Giuseppina Di Salvo, Sasha L. Fulton, Jennifer C Chan, Lorna A. Farrelly, Ashley E. Lepack, Ryan M. Bastle, Lingchun Kong, Flurin Cathomas, Emily L. Newman, Caroline Menard, Aarthi Ramakrishnan, Polina Safovich, Yang Lyu, Herbert E. Covington, Li Shen, Kelly Gleason, Carol A. Tamminga, Scott J. Russo, Ian Maze
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence levels of mood disorders, including major depressive disorder (MDD), stress-media
Externí odkaz:
https://doaj.org/article/b2c5b24c092e46f3a1215efcaf06b44a
Autor:
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The molecular mechanisms underlying deficits in Down syndrome remain unclear. Here, the authors show that copy number restoration of a chromatin remodeler in trisomic mice is sufficient to rescue epigenomic, physiological and cognitive deficits.
Externí odkaz:
https://doaj.org/article/4d9fc438d0e34047a77c7e2c58308fbb
Autor:
Sasha L. Fulton, Swarup Mitra, Ashley E. Lepack, Jennifer A. Martin, Andrew F. Stewart, Jacob Converse, Mason Hochstetler, David M. Dietz, Ian Maze
Publikováno v:
Neuropsychopharmacology. 47:1776-1783
Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disorder. Recent data from our laboratory indicate that aberrant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab9f7388d1434822253458ae30e8e08a
https://doi.org/10.1038/s41386-022-01279-4
https://doi.org/10.1038/s41386-022-01279-4
Autor:
Andrea Navarria, Eric S. Wohleb, Bhavya Voleti, Kristie T. Ota, Sophie Dutheil, Ashley E. Lepack, Jason M. Dwyer, Manabu Fuchikami, Astrid Becker, Filippo Drago, Ronald S. Duman
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 254-261 (2015)
Clinical studies demonstrate that scopolamine, a non-selective muscarinic acetylcholine receptor (mAchR) antagonist, produces rapid therapeutic effects in depressed patients, and preclinical studies report that the actions of scopolamine require glut
Externí odkaz:
https://doaj.org/article/c51e48a2351f450da577abe0ab0d61fb
Publikováno v:
Molecular and Cellular Neuroscience. 125:103824
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::899c696f0e4e68cb9abff4e1573c1c00
https://doi.org/10.1016/j.mcn.2023.103824
https://doi.org/10.1016/j.mcn.2023.103824
Autor:
Zi-Jun Wang, Erin S. Calipari, Henrik Molina, Swarup Mitra, Ryan M. Bastle, Ian Maze, Yang Lyu, Paul J. Kenny, Li Shen, David M. Dietz, Richard M. O'Connor, Lorna A. Farrelly, Jennifer A. Martin, Gustavo Turecki, Aarthi Ramakrishnan, Sasha L. Fulton, Alexander C.W. Smith, Ashley E. Lepack, Craig T. Werner, Ping Zhong, Zhen Yan, Andrew F. Stewart
Publikováno v:
Science
More than a normal neurotransmitter The molecular mechanisms underlying the persistence of addiction remain largely unclear. Lepack et al. found that, with cocaine exposure, there is an intracellular accumulation of dopamine in neurons of a brain reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0424a39f269dc3e8d62f411b94b078ef
https://doi.org/10.1126/science.aaw8806
https://doi.org/10.1126/science.aaw8806
Autor:
Hope Kronman, Zachary S. Lorsch, Marine Salery, Lyonna F. Parise, Ian Maze, Li Shen, Andrew Conkey, Gustavo Turecki, Yong-Hwee E. Loh, Orna Issler, Ann E. Symonds, Eric J. Nestler, Ashley E. Lepack, Benoit Labonté, Rosemary C. Bagot, Peter J. Hamilton, Stephen T. Pirpinias, Yan Dong, Idelisse Ortiz Torres, Rachael L. Neve, Sarah E. Montgomery, Xianxiao Zhou, Philipp Mews, Eric M. Parise, Aarthi Ramakrishnan, Andrew M. McKenzie, William J. Wright, Bin Zhang
Publikováno v:
Nature neuroscience
Understanding the transcriptional changes that are engaged in stress resilience may reveal novel antidepressant targets. Here we use gene co-expression analysis of RNA-sequencing data from brains of resilient mice to identify a gene network that is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c23afeb4c06e432b7ececa88ba3c3b0
http://europepmc.org/articles/PMC6713580
http://europepmc.org/articles/PMC6713580
Autor:
Ian Maze, Kelly J. Heard, Natalia Alenina, Henrik Molina, Bradley J. Lukasak, Ryan M. Bastle, Fred H. Gage, Michael Bader, Tom W. Muir, Krishna C. Vadodaria, Baichao Zhang, Robert E. Thompson, Natarajan V. Bhanu, Robert G. Roeder, Shuai Zhao, Tomoyoshi Nakadai, Yang Lyu, Aarthi Ramakrishnan, Olivier Berton, Lorna A. Farrelly, Li Shen, Henry Zebroski, Haitao Li, Benjamin A. Garcia, Ashley E. Lepack, Galina Erikson, Yong-Hwee E. Loh
Publikováno v:
Nature. 567:535-539
Chemical modifications of histones can mediate diverse DNA-templated processes, including gene transcription1–3. Here we provide evidence for a class of histone post-translational modification, serotonylation of glutamine, which occurs at position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6c9a79ccc89fe0271131086b5e6c2e8
https://doi.org/10.1038/s41586-019-1024-7
https://doi.org/10.1038/s41586-019-1024-7
Autor:
Sasha L, Fulton, Swarup, Mitra, Ashley E, Lepack, Jennifer A, Martin, Andrew F, Stewart, Jacob, Converse, Mason, Hochstetler, David M, Dietz, Ian, Maze
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(10)
Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disorder. Recent data from our laboratory indicate that aberrant a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be64f58a64d1983da1ef7c8c89031922
https://pubmed.ncbi.nlm.nih.gov/35094023
https://pubmed.ncbi.nlm.nih.gov/35094023
Autor:
Ashley E. Lepack, Sasha L. Fulton, Jennifer A. Martin, Swarup Mitra, Ian Maze, David M. Dietz
Persistent transcriptional eventsamples were incubated on ice for 30 min and then centrifugeds in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that characterize substance use disor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f54b881e9ee12ac3a0c4b5e59907376
https://doi.org/10.1101/2021.03.26.437235
https://doi.org/10.1101/2021.03.26.437235
