Výsledky vyhledávání - "Ashley D. Himes"

Notch Signaling in Postnatal Pituitary Expansion: Proliferation, Progenitors, and Cell Specification

Autor: Lori T. Raetzman, Dan R. Getz, Ashley D. Himes, Leah B. Nantie

Publikováno v: Molecular Endocrinology. 28:731-744

Mutations in PROP1 account for up to half of the cases of combined pituitary hormone deficiency that result from known causes. Despite this, few signaling molecules and pathways that influence PROP1 expression have been identified. Notch signaling ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2911f648f6a07cd6f63eb92829d67a56
https://doi.org/10.1210/me.2013-1425

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p21, an important mediator of quiescence during pituitary tumor formation, is dispensable for normal pituitary development during embryogenesis

Autor: Lori T. Raetzman, Agata Parfieniuk, Pamela Monahan, Ashley D. Himes

Publikováno v: Mechanisms of Development. 128(11-12):640-652

A delicate balance between proliferation and differentiation must be maintained in the developing pituitary to ensure the formation of the appropriate number of hormone producing cells. In the adult, proliferation is actively restrained to prevent tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af8626864fc3da769296e6513c23a1b

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N-Cadherin Loss in POMC-Expressing Cells Leads to Pituitary Disorganization

Autor: Rachel M. Fiddler, Lori T. Raetzman, Ashley D. Himes

Publikováno v: Molecular Endocrinology. 25:482-491

Pituitary tumors are the third most common intracranial tumor in humans and can cause altered hormone secretions leading to hypercortisolism, acromegaly, and infertility. Reduced expression of the cell adhesion molecule N-cadherin has been linked wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c418a360d11574d352bb1ff489178cd1
https://doi.org/10.1210/me.2010-0313

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Prenatal Exposure to Low Doses of Bisphenol A Increases Pituitary Proliferation and Gonadotroph Number in Female Mice Offspring at Birth1

Autor: Wei Wang, Zelieann R. Craig, Lori T. Raetzman, Jackye Peretz, Jodi A. Flaws, Katherine E. Brannick, Ashley D. Himes

The pituitary gland is composed of hormone-producing cells essential for homeostasis and reproduction. Pituitary cells are sensitive to endocrine feedback in the adult and can have altered hormonal secretion from exposure to the endocrine disruptor b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f8d69f51f6ecd264e0ac4b4bb48f453
https://europepmc.org/articles/PMC3507543/

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Regulation of p21 Is Necessary to Control Pituitary Progenitor Cell Expansion

Autor: Pamela Monahan, Ashley D. Himes, Lori T. Raetzman

Publikováno v: Biology of Reproduction. 83:36-36

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05db528c87d26d8cc539091d38b5f851
https://doi.org/10.1093/biolreprod/83.s1.36

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Premature differentiation and aberrant movement of pituitary cells lacking both Hes1 and Prop1

Autor: Lori T. Raetzman, Ashley D. Himes

Publikováno v: Developmental Biology. (1):151-161

In the pituitary, the transition from proliferating progenitor cell into differentiated hormone producing cell is carefully regulated in a time-dependent and spatially-restricted manner. We report that two targets of Notch signaling, Hes1 and Prop1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0bc1d414e984d0d6ce2fa5646adbe

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