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O-glycosylation of Sp1 and transcriptional regulation of the calmodulin gene by insulin and glucagon
Autor:
Antonio Martinez-Hernandez, Rajendra Raghow, Gipsy Majumdar, Rosalind Pitpitan Candelaria, Solomon S. Solomon, Ashley D. Harmon
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 285:E584-E591
Both insulin and glucagon stimulate steady-state levels of Sp1 transcription factor, but only insulin stimulates transcription of the calmodulin (CaM) gene in liver. Because O-glycosylation of Sp1 by O-linked N-acetylglucosamine ( O-GlcNAc) is though