Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Ashley D. Derezinski"'
Autor:
Amy J. Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David B. Gregornik, Keith Brown, Ulrich Broeckel, Gunter Scharer
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Complex regions in the human genome such as repeat motifs, pseudogenes and structural (SVs) and copy number variations (CNVs) present ongoing challenges to accurate genetic analysis, particularly for short-read Next-Generation-Sequencing (NGS) techno
Externí odkaz:
https://doaj.org/article/6fa0fec7755a47f89cb10893ddece312
Autor:
Wendy Y. Wang, David Twesigomwe, Charity Nofziger, Amy J. Turner, Lena-Sophie Helmecke, Ulrich Broeckel, Ashley D. Derezinski, Scott Hazelhurst, Andrea Gaedigk
Publikováno v:
Journal of Personalized Medicine; Volume 12; Issue 10; Pages: 1575
The CYP2D6 gene has been widely studied to characterize variants and/or star alleles, which account for a significant portion of variability in drug responses observed within and between populations. However, African populations remain under-represen
Autor:
Wendy Y, Wang, David, Twesigomwe, Charity, Nofziger, Amy J, Turner, Lena-Sophie, Helmecke, Ulrich, Broeckel, Ashley D, Derezinski, Scott, Hazelhurst, Andrea, Gaedigk
Publikováno v:
Journal of personalized medicine. 12(10)
The
Autor:
Mary V. Relling, Erin C. Boone, Cyrine-Eliana Haidar, Ulrich Broeckel, Praful Aggarwal, Andrea Gaedigk, Amy Turner, Ashley D. Derezinski
Publikováno v:
J Mol Diagn
Cytochrome P450 2D6 (CYP2D6) copy number (CN) variation affects the metabolism of numerous prescribed drugs. Sequence variation within primer or probe target regions of hydrolysis probe CN assays can generate false-positive calls for CN loss. Further