Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ashley C. Knight"'
Autor:
Brian J. Lopresti, N. Scott Mason, Laszlo Rakos, Anton Lindberg, Johan Sandell, William E. Klunk, Chester A. Mathis, Neil Vasdev, Daniel Sohn, Jeffrey S. Stehouwer, Ashley C Knight, April Radelet, Alexander Sandberg, Per Hammarström, Junchao Tong, Samuel P.S. Svensson
Publikováno v:
ACS Chemical Neuroscience. 12:596-602
CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [3H]CBD-2115 had a KD value of 6.9 nM and a nominal Bmax of 500 nM in 4R-tau expressing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ac8efd7517f2803edd4e060ec244db
https://doi.org/10.1021/acschemneuro.0c00801
https://doi.org/10.1021/acschemneuro.0c00801
Publikováno v:
Brain communications. 4(1)
Chronic traumatic encephalopathy is a neurological disorder associated with head trauma and is confirmed upon autopsy. PET imaging of chronic traumatic encephalopathy may provide a means to move towards ante-mortem diagnosis and therapeutic intervent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2839c9e2466341314a5e8c3d4c2dee9c
https://pubmed.ncbi.nlm.nih.gov/35198978
https://pubmed.ncbi.nlm.nih.gov/35198978
Autor:
Peter J. H. Scott, Debasis Patnaik, Xia Shao, Lucius L Xuan, Nicolas Salem, Phillip S. Sherman, Surya A. Reis, Ashley C Knight, Andrew V. Mossine, Jenelle Stauff, Shil Patel, Peter S. Chindavong, Lisa Wells, David R. Bonsall, Neil Vasdev, Jinshan Michael Chen, Stephen J. Haggarty, Ravi G. Kurumbail, Janna Arteaga, Wen-Ning Zhao, Chialin Cheng, Laurent Martarello, Steven H. Liang, Vadim Bernard-Gauthier, Brenda Amaral, Hema S. Krishnan, Cassis Varlow
Publikováno v:
Journal of Medicinal Chemistry. 62:9600-9617
Using structure-guided design, several cell based assays, and microdosed positron emission tomography (PET) imaging, we identified a series of highly potent, selective, and brain-penetrant oxazole-4-carboxamide-based inhibitors of glycogen synthase k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f19c69be22ace49ff49e06bec2585
https://doi.org/10.1021/acs.jmedchem.9b01030
https://doi.org/10.1021/acs.jmedchem.9b01030
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Glycogen synthase kinase-3 (GSK-3) is a positron emission tomography (PET) imaging target with implications in the pathogenesis of Alzheimer’s disease (AD). This preliminary study evaluates human AD and transgenic P301L mouse brai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32579149ed2d764ba84b4adef1b8f4f8
https://pubmed.ncbi.nlm.nih.gov/34423266
https://pubmed.ncbi.nlm.nih.gov/34423266
Autor:
Neil Vasdev, Karl T. Schmidt, Ashley C Knight, Shil Patel, Lee Josephson, Tong Zi, Steven H. Liang, Cassis Varlow
Publikováno v:
ACS Chem Neurosci
Microglia play a role in several central nervous system (CNS) diseases and are a highly sought target for positron emission tomography (PET) imaging and therapeutic intervention. 5-Cyano-N-(4-(4-[11C]methylpiperazin-1-yl)-2-(piperidin-1-yl)phenyl)fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec6bdd7562b53907a59cbd28f8820c6
https://europepmc.org/articles/PMC9350903/
https://europepmc.org/articles/PMC9350903/
Autor:
Anton, Lindberg, Ashley C, Knight, Daniel, Sohn, Laszlo, Rakos, Junchao, Tong, April, Radelet, N Scott, Mason, Jeffrey S, Stehouwer, Brian J, Lopresti, William E, Klunk, Johan, Sandell, Alexander, Sandberg, Per, Hammarström, Samuel, Svensson, Chester A, Mathis, Neil, Vasdev
Publikováno v:
ACS Chem Neurosci
CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [(3)H]CBD-2115 had a K(D) value of 6.9 nM and a nominal B(max) of 500 nM in 4R-tau expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2a1e1c145f58314eb744adf59f1e2505
https://pubmed.ncbi.nlm.nih.gov/33497190
https://pubmed.ncbi.nlm.nih.gov/33497190
Autor:
Jeff Stehouwer, Junchao Tong, Daniel Sohn, Ashley C Knight, Neil Vasdev, Chester A. Mathis, William E. Klunk, Laszlo Rakos, Samuel P.S. Svensson, Johan Sandell, Anton Lindberg, Brian J. Lopresti, Per Hammarström, N. Scott Mason, April Radelet, Alexander Sandberg
Publikováno v:
Nuclear Medicine and Biology. :S9-S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb4d58da489cb5a808406fe2f2a1afeb
https://doi.org/10.1016/s0969-8051(21)00282-1
https://doi.org/10.1016/s0969-8051(21)00282-1
Autor:
Filomena G. Ottaviano, Tejvir S. Khurana, Ionita Ghiran, Bridget Simonson, Vinita Subramanya, Maria I. Kontaridis, Danielle Hunt, Hannabeth Franchino, Ashley C. Knight, Saumya Das, Mun Chun Chan, Aifeng Zhang, Manoj K. Mishra, Anthony Rosenzweig
Publikováno v:
Science signaling. 10(468)
Physiological cardiac hypertrophy, in response to stimuli such as exercise, is considered adaptive and beneficial. In contrast, pathological cardiac hypertrophy that arises in response to pathological stimuli such as unrestrained high blood pressure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ee92b72fe569994dded9de271e8f54
https://pubmed.ncbi.nlm.nih.gov/28246202
https://pubmed.ncbi.nlm.nih.gov/28246202
Autor:
Saumya Das, Gordon F. Tomaselli, Michael A. Rosenberg, Filomena G. Ottaviano, Katherine Hessler, Patrick T. Ellinor, Michael J. Begley, Ashley C. Knight, Anthony Rosenzweig, Federica del Monte, Takeshi Aiba, Chunyang Xiao, Pablo A. Quintero, Pontus Boström, Lewis C. Cantley, Evan L. Graham, Michael R. Morissette
Publikováno v:
Circulation. 126(18)
Background— Heart failure is a growing cause of morbidity and mortality. Cardiac phosphatidylinositol 3-kinase signaling promotes cardiomyocyte survival and function, but it is paradoxically activated in heart failure, suggesting that chronic activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee193b8291f6d0a7afb94389fdae23e
https://pubmed.ncbi.nlm.nih.gov/23019295
https://pubmed.ncbi.nlm.nih.gov/23019295
Publikováno v:
Human genetics. 131(1)
Atrial fibrillation (AF) affects more than 5 million people worldwide; however, none of the anti-arrhythmic drugs available now are entirely optimal in terms of efficacy and safety. A better understanding of the molecular mechanism of AF will facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::431d8df8aecb149a31dfc0361a54288a
https://pubmed.ncbi.nlm.nih.gov/21735173
https://pubmed.ncbi.nlm.nih.gov/21735173