Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ashley Bispo"'
Autor:
Antonio Cibelli, David Ballesteros-Gomez, Sean McCutcheon, Greta L. Yang, Ashley Bispo, Michael Krawchuk, Giselle Piedra, David C. Spray
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110069- (2024)
Summary: Astrocyte endfeet enwrap brain vasculature, forming a boundary for perivascular glymphatic flow of fluid and solutes along and across the astrocyte endfeet into the brain parenchyma. We evaluated astrocyte sensitivity to shear stress generat
Externí odkaz:
https://doaj.org/article/e785a16960634e1ab01957d07650810f
Autor:
Victor Hugo Bustos, Yashoda Krishna Sunkari, Anjana Sinha, Maria Pulina, Ashley Bispo, Maya Hopkins, Alison Lam, Sydney F. Kriegsman, Emily Mui, Emily Chang, Ana Jedlicki, Hannah Rosenthal, Marc Flajolet, Paul Greengard, Subhash C. Sinha
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the accumulation of beta-amyloid (Aβ), C99, and Tau in vulnerable areas of the brain. Despite extensive research, current strategies to lower Aβ levels have sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b996c2596047e1f36028280741db2409
https://doi.org/10.1101/2023.04.28.538773
https://doi.org/10.1101/2023.04.28.538773
Autor:
Ukpong B. Eyo, Long Jun Wu, Sruchika Sabu, Junting Liu, Yamei Tang, Huaye Zhang, Madhuvika Murugan, Ashley Bispo, Victoria L. DiBona, Jiaying Zheng, Rong Wu
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Microglia are known to engage in physical interactions with neurons. However, our understanding of the detailed mechanistic regulation of microglia-neuron interactions is incomplete. Here, using high resolution two photon imaging, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dfb725573eaa44cf765c14803c8151
http://link.springer.com/article/10.1038/s41598-018-19205-4
http://link.springer.com/article/10.1038/s41598-018-19205-4
Autor:
Fred S. Gorelick, Ashley Bispo, Paul Greengard, Alison Lam, Victor Bustos, Marc Flajolet, Maria V. Pulina
Presenilin 1 (PS1), the catalytic subunit of the γ-secretase complex, cleaves βCTF to produce Aβ. We have shown that PS1 regulates Aβ levels by a unique bifunctional mechanism. In addition to its known role as the catalytic subunit of the γ-secr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9503669d7b9a5e9f45713b71ee4a052d
https://europepmc.org/articles/PMC5502640/
https://europepmc.org/articles/PMC5502640/
Autor:
Jiyun Peng, Ukpong B. Eyo, Przemyslaw Swiatkowski, Long Jun Wu, Aparna Mukherjee, Ashley Bispo
Microglia are highly dynamic immune cells of the CNS and their dynamism is proposed to be regulated by neuronal activities. However, the mechanisms underlying neuronal regulation of microglial dynamism have not been determined. Here, we found an incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ee90691fe58d943eb34e67625fd852
https://europepmc.org/articles/PMC4200107/
https://europepmc.org/articles/PMC4200107/