Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ashley B. Palete"'
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112436- (2023)
Summary: PSGL-1 (P-selectin glycoprotein-1) is a T cell-intrinsic checkpoint regulator of exhaustion with an unknown mechanism of action. Here, we show that PSGL-1 acts upstream of PD-1 and requires co-ligation with the T cell receptor (TCR) to atten
Externí odkaz:
https://doaj.org/article/067e0e4ee8fd4b5a973b514304627b4f
Autor:
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Monique L. Henriquez, Hyungseok Seo, Xue Lei, Eric S. Wang, Roberto Tinoco, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Summary/AbstractWe previously identified the adhesion molecule PSGL-1 as a T cell intrinsic immune checkpoint regulator of T cell exhaustion. Here we show that the ability of PSGL-1 to restrain TCR sginaling correlates with decreased expression of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eb51d4fbb8372cd62d613e21bec9d52
https://doi.org/10.1101/2022.01.24.477602
https://doi.org/10.1101/2022.01.24.477602
Autor:
Eun-ah Bae, Jennifer L Hope, Dennis C Otero, Hannah A Faso, Ashley B Palete, Ze’ev A Ronai, Linda M Bradley
Publikováno v:
The Journal of Immunology. 206:14.12-14.12
Functional T cell exhaustion develops with persistent antigen exposure during chronic viral infection and cancer. Greater insights into T cell exhaustion are needed to promote immunity to viruses and tumors. RNF5 (RING-finger protein 5) is an E3 ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab20f340686a6482bb29ec058e0c8cb1
https://doi.org/10.4049/jimmunol.206.supp.14.12
https://doi.org/10.4049/jimmunol.206.supp.14.12
Autor:
Hannah A. Faso, Eun-ah Bae, Christopher J. Stairiker, Garth Powis, Jennifer L. Hope, Dennis C. Otero, Linda M. Bradley, Ashley B. Palete, Petrus R. de Jong
Publikováno v:
Cancer Immunology Research. 9:PO014-PO014
We previously identified that the adhesion molecule P-selectin glycoprotein ligand-1 (PSGL-1) regulates T cell function and exhaustion in responses to chronic viral infection and melanoma tumors. Subsequently, our studies have focused on investigatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8b95315f15deb5ffdb7f45a712f8faa
https://doi.org/10.1158/2326-6074.tumimm20-po014
https://doi.org/10.1158/2326-6074.tumimm20-po014
Autor:
Eun-ah Bae, Jennifer L Hope, Dennis C Otero, Christopher J Stairiker, Hannah A Faso, Ashley B Palete, Linda M Bradley
Publikováno v:
The Journal of Immunology. 204:150.9-150.9
Endoplasmic reticulum (ER) stress is induced by the accumulation of misfolded proteins and other cellular stresses, which lead to the unfolded protein response to restore ER homeostasis. Previous studies have shown that the ER stress response is requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699e170b4cf2c72023cf59923339907a
https://doi.org/10.4049/jimmunol.204.supp.150.9
https://doi.org/10.4049/jimmunol.204.supp.150.9
Autor:
Jennifer L Hope, Dennis C Otero, Eun-ah Bae, Christopher J Stairiker, Ashley B Palete, Hannah A Faso, Petrus de Jong, Garth Powis, Linda M Bradley
Publikováno v:
The Journal of Immunology. 204:240.1-240.1
We previously identified that the adhesion molecule P-selectin glycoprotein ligand-1 (PSGL-1) regulates T cell function and exhaustion in response to chronic viral infection and tumors. Subsequent studies have focused on investigating the role of PSG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d5e8ed1de7f98c8606c518b8dc085b0
https://doi.org/10.4049/jimmunol.204.supp.240.1
https://doi.org/10.4049/jimmunol.204.supp.240.1