Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ashley Azar"'
Autor:
Timothy Nacarelli, Ashley Azar, Manali Potnis, Gregg Johannes, Joshua Mell, F. Brad Johnson, Holly Brown-Borg, Eishi Noguchi, Christian Sell
Publikováno v:
Molecular biology of the cell. 33(5)
Cellular senescence is a terminal cell fate characterized by growth arrest and a metabolically active state characterized by high glycolytic activity. Human fibroblasts were placed in a unique metabolic state using a combination of methionine restric
Autor:
Ashley Azar, Kathryn Devlin, Joshua Chang Mell, Tania Giovannetti, Vanessa Pirrone, Michael R Nonnemacher, Shendra Passic, Katherine Kercher, Jean W Williams, Jeffery M Jacobson, Brian Wigdahl, William Dampier, David J Libon, Christian Sell
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0163772 (2016)
Evolutionary divergence of the mitochondrial genome has given rise to distinct haplogroups. These haplogroups have arisen in specific geographical locations and are responsible for subtle functional changes in the mitochondria that may provide an evo
Externí odkaz:
https://doaj.org/article/63cdb8658ef24f08bdf70dc6849a4ed0
Publikováno v:
GeroScience. 40:243-256
Inhibition of mTOR signaling using rapamycin has been shown to increase lifespan and healthspan in multiple model organisms; however, the precise mechanisms for the beneficial effects of rapamycin remain uncertain. We have previously reported that ra
Autor:
Claudio Torres, Michael Bene, Christian Sell, Ashley Azar, Timothy Nacarelli, Gregg J. Johannes, Ibiyonu Lawrence, Justin Cohen
Publikováno v:
GeroScience. 40:193-199
Cellular senescence is a central component of the aging process. This cellular response has been found to be induced by multiple forms of molecular damage and senescent cells increase in number with age in all tissues examined to date. We have examin
Publikováno v:
Annals of the New York Academy of Sciences. 1418:95-105
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin r
Publikováno v:
Innovation in Aging
Cellular senescence is a cell fate defined by an irreversible cell-cycle arrest and a pro-inflammatory secretory profile. It is a consequence of a shift in metabolism and rearrangement of chromatin. Accumulation of senescent cells is a universal hall
Publikováno v:
Annals of the New York Academy of Sciences. 1418(1)
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin r
Unexpected activation of mTOR signaling, measured by ribosomal S6 phosphorylation or ribosomal S6 kinase (p70S6K) activity, has been reported in aging-related settings. Evidence of elevated mTOR activity has been reported in the heart and muscle tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f6c3fade42a7715e3084e1bea4a8e8
https://europepmc.org/articles/PMC4589173/
https://europepmc.org/articles/PMC4589173/
Autor:
Ashley Azar, Joshua Chang Mell, Christian Sell, Brian Wigdhal, J.M. Jacobson, Kathryn N. Devlin, Vanessa Pirrone, Tania Giovannetti, Michael R. Nonnemacher, David J. Libon, Will Dampier, Eunice Lee
Publikováno v:
Experimental Gerontology. 94:113
Publikováno v:
Frontiers in Endocrinology, Vol 5 (2014)
Frontiers in Endocrinology
Frontiers in Endocrinology
The regulation of mitochondrial mass and DNA content involves a complex interaction between mitochondrial DNA replication machinery, functional components of the electron transport chain, selective clearance of mitochondria, and nuclear gene expressi