Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ashley McCarron"'
Autor:
Adiseshu Kattuboina, Frederick Hicks, Ian Armitage, Jennifer S. N. Li, Ashley McCarron, Lei Zhu, Mingkun Fu
Publikováno v:
Journal of Heterocyclic Chemistry. 54:728-734
In efforts to optimize a manufacturing process for an internal development compound, a clean, efficient approach to guanidine synthesis using chloroformamidine hydrochloride was identified. To investigate the general utility of this methodology towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2120e581d89cfd62113db50d09b48c3
https://doi.org/10.1002/jhet.2567
https://doi.org/10.1002/jhet.2567
Autor:
Erin O’Brien, Frederick Hicks, Matt Stirling, Quentin J. McCubbin, Lei Zhu, Ashley McCarron, Eric L. Elliott, Ian Armitage, Marianne Langston
Publikováno v:
Organic Process Research & Development. 19:1299-1307
A practical synthesis of a novel NEDD8-activating enzyme (NAE) inhibitor pevonedistat (MLN4924) is described. Key steps include an enantioselective synthesis of an amino-diol cyclopentane intermediate containing three chiral centers and a novel, regi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b993e38701133292aca68c4fcf27183e
https://doi.org/10.1021/acs.oprd.5b00209
https://doi.org/10.1021/acs.oprd.5b00209
Autor:
Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Hirotaki Mizutani, Steven Langston, Stepan Vyskocil, Ian Armitage, Ashley McCarron, Lei Zhu, Ian M. Bell, Paul G. Bulger, Mark McLaughlin, Jason S. Tedrow, Wenge Zhong, Christian Harcken, Hossein Razavi, Jonathan T. Reeves, Daniel R. Fandrick, Jinhua J. Song, Zhulin Tan, Soojin Kim, Bing-Shiou Yang, Nathan K. Yee, Chris H. Senanayake, Remy Angelaud, Daniel P. Sutherlin, Mark Reynolds, Scott Savage, Andreas Stumpf, Srinivasan Babu, Francis Gosselin, Theresa Humphries, Alan Olivero, Daniel Sutherlin, Qingping Tian, Erick W. Co, Julian P. Henschke
Autor:
Yongquan Hou, Qiang Yang, Tatsuya Ito, Frederick Hicks, Jie Huang, Matthew Johnson, David Provencal, Liu Yuqiang, Yuxin Zhao, Erin O’Brien, Yan Sitang, Chunrong Ma, Christopher Matthews, Ashley McCarron, Marianne Langston, Li Heyang, Colin O'bryan
Publikováno v:
Organic Process Research & Development. 17:829-837
Progression toward a scalable synthesis of TORC1/2 inhibitor bulk drug, culminating in the first GMP manufacturing campaign, is described. Process research and development was needed to obtain the prerequisite stereocenter in high enantiomeric excess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41df89f4ab6c809d8d5ced875329c1fc
https://doi.org/10.1021/op300330f
https://doi.org/10.1021/op300330f
Publikováno v:
ACS Symposium Series ISBN: 9780841231917
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde022b7cf6accaa640155b40421fabc
https://doi.org/10.1021/bk-2016-1240.ch002
https://doi.org/10.1021/bk-2016-1240.ch002
Autor:
Ian Armitage, Eric L. Elliott, Frederick Hicks, Marianne Langston, Ashley McCarron, QuentinJ. McCubbin, Erin O’Brien, Matt Stirling, Lei Zhu
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1299-1307, 9p