Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ashley, Saint Fleur"'
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Neutralizing antibody plays a key role in protecting hosts from invasive pathogens and their virulent components. Current high-throughput assays for antibody screening are based on binding activities. However, those antibodies wit
Externí odkaz:
https://doaj.org/article/f22f3e760eaf41d38ac60e19fe5254c4
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Clostridioides difficile is the most prevalent pathogen of nosocomial diarrhea. In the United States, over 450,000 cases of C. difficile infection (CDI), responsible for more than 29,000 deaths, are reported annually in recent years. Because of the e
Externí odkaz:
https://doaj.org/article/808a5b0afefb4dea96027a64bf4abf1d
Autor:
Yongrong Zhang, Shan Li, Zhiyong Yang, Lianfa Shi, Hua Yu, Rosangela Salerno-Goncalves, Ashley Saint Fleur, Hanping Feng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 611-625 (2018)
Background & Aims: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar doma
Externí odkaz:
https://doaj.org/article/fdacdf7c94c941a6bc7143daec5f33a3
Autor:
James E. Galen, Hua Yu, Ashley Saint Fleur, Therwa Hamza, Kevin Chen, Yongrong Zhang, Yixuan Zhu, Hanping Feng, Zhiyong Yang
Publikováno v:
Sci Transl Med
Antibiotic-resistant Clostridioides difficile is an anaerobic Gram-positive bacterium that colonizes the colon and is responsible for more than 29,000 deaths in the United States each year. Hence, C. difficile infection (CDI) poses an urgent threat t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96ec0d534e7a6c1af8af0e04f5a02eb
https://europepmc.org/articles/PMC7692727/
https://europepmc.org/articles/PMC7692727/
Autor:
Lianfa Shi, Hua Yu, Zhiyong Yang, Hanping Feng, Shan Li, Ashley Saint Fleur, Yongrong Zhang, Rosangela Salerno-Goncalves
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 4, Pp 611-625 (2018)
Background & Aims: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f07468b0bd387a21f65a1cd803318ca
https://doi.org/10.1016/j.jcmgh.2018.01.022
https://doi.org/10.1016/j.jcmgh.2018.01.022
Autor:
David B. Weiner, Amir S. Khan, Elizabeth K. Duperret, Hy Levitsky, Kimberly A. Kraynyak, Jaemi Chu, Bernadette Ferraro, Jian Yan, Niranjan Y. Sardesai, Jewell Walters, Ashley Saint-Fleur
Publikováno v:
Molecular Therapy. 25:976-988
Tumor-associated antigens have emerged as important immunotherapeutic targets in the fight against cancer. Germline tumor antigens, such as WT1, Wilms’ tumor gene 1, are overexpressed in many human malignancies but have low expression in somatic ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf9873b9c4cfa5ecd11f97fe66beb06
https://doi.org/10.1016/j.ymthe.2017.01.022
https://doi.org/10.1016/j.ymthe.2017.01.022
Autor:
Yongrong, Zhang, Shan, Li, Zhiyong, Yang, Lianfa, Shi, Hua, Yu, Rosangela, Salerno-Goncalves, Ashley, Saint Fleur, Hanping, Feng
Publikováno v:
Cellular and molecular gastroenterology and hepatology. 5(4)
Here, we investigated toxin domain functions that regulate the proinflammatory activity ofBlocking autoprocessing of TcdB by mutagenesis or chemical inhibition, while reducing cytotoxicity of the toxin, significantly enhanced its proinflammatory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86b0e2fe1c39b737d321d6492a5f00d8
https://pubmed.ncbi.nlm.nih.gov/29930981
https://pubmed.ncbi.nlm.nih.gov/29930981
Autor:
Jonathon Heath, Hua Yu, Kevin Chen, Hanping Feng, Ashley Saint Fleur, Ye Chen, Fenfen Zhou, Yongrong Zhang, Therwa Hamza, Haihui Huang
Publikováno v:
Inflammatory bowel diseases. 24(3)
Background Over the past several decades, there has been a significant increase in the incidence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD). However, a wild-type animal model is not available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac43f2a6cd346f000767dc8d0c5e32be
https://pubmed.ncbi.nlm.nih.gov/29462386
https://pubmed.ncbi.nlm.nih.gov/29462386
Autor:
Lianfa Shi, Guang Bai, Kevin Chen, Ashley Saint Fleur, Hua Yu, Yongrong Zhang, Zhiyong Yang, Hanping Feng
Clostridium difficile infection (CDI) is the most common cause of antibiotic associated diarrhea and colitis in developed countries. The disease is mainly mediated via two major exotoxins TcdA and TcdB secreted by the bacterium. We have previously de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8fe8320ad8bcbb24c6057c3306e616
https://europepmc.org/articles/PMC5985491/
https://europepmc.org/articles/PMC5985491/
Autor:
Xiu-fen Liu, Tapan K. Bera, Satoshi Nagata, Byungkook Lee, Ira Pastan, Duc Ha, Tomoko Ise, Ashley Saint Fleur, Y C Lee, Yoonsoo Hahn
Publikováno v:
Proceedings of the National Academy of Sciences. 103:17885-17890
We previously described a primate-specific gene family, POTE, that is expressed in many cancers but in a limited number of normal organs. The 13 POTE genes are dispersed among eight different chromosomes and evolved by duplications and remodeling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb33809977416d78b52a42495a671d1c
https://doi.org/10.1073/pnas.0608344103
https://doi.org/10.1073/pnas.0608344103