Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

Autor: Maiken Mellergaard, Sarah Line Skovbakke, Stine Dam Jepsen, Nafsika Panagiotopoulou, Amalie Bøge Rud Hansen, Weihua Tian, Astrid Lund, Rikke Illum Høgh, Sofie Hedlund Møller, Romain Guérillot, Ashleigh S. Hayes, Lise Tornvig Erikstrup, Lars Andresen, Anton Y. Peleg, Anders Rhod Larsen, Timothy P. Stinear, Aase Handberg, Christian Erikstrup, Benjamin P. Howden, Steffen Goletz, Dorte Frees, Søren Skov

Publikováno v: mBio, Vol 14, Iss 5 (2023)

ABSTRACT Staphylococcus aureus (S. aureus) represents a major clinical challenge due to its explicit capacity to select mutations that increase antibiotic resistance and immune evasion. However, the molecular mechanisms are poorly defined, especially

Externí odkaz: https://doaj.org/article/817c94db797b4d7f9d66769bae0854a0

Cell Membrane Adaptations Mediate β-Lactam-Induced Resensitization of Daptomycin-Resistant (DAP-R) Staphylococcus aureus In Vitro

Autor: Nagendra N. Mishra, Arnold S. Bayer, Sarah L. Baines, Ashleigh S. Hayes, Benjamin P. Howden, Christian K. Lapitan, Cassandra Lew, Warren E. Rose

Publikováno v: Microorganisms, Vol 9, Iss 5, p 1028 (2021)

The reversal of daptomycin resistance in MRSA to a daptomycin-susceptible phenotype following prolonged passage in selected β-lactams occurs coincident with the accumulation of multiple point mutations in the mprF gene. MprF regulates surface charge

Externí odkaz: https://doaj.org/article/5fe360cff39a4bff86b3f42d2650c7b1

Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

Autor: Anders Rhod Larsen, Ashleigh S Hayes, Søren Skov, Romain Guérillot, Dorte Frees, Anton Y. Peleg, Benjamin P Howden, Blanca I. Aldana, Sofie Hedlund Møller, Rikke Illum Høgh, Timothy P. Stinear, Stine Dam Jepsen, Lars Andresen, Maiken Mellergaard, Nafsika Panagiotopoulou, Zofija Frimand, Helle S. Waagepetersen, Astrid Lund, Camilla Hartmann Friis Hansen

Publikováno v: Mellergaard, M, Høgh, R I, Lund, A, Aldana, B I, Guérillot, R, Møller, S H, Hayes, A S, Panagiotopoulou, N, Frimand, Z, Jepsen, S D, Hansen, C H F, Andresen, L, Larsen, A R, Peleg, A Y, Stinear, T P, Howden, B P, Waagepetersen, H S, Frees, D & Skov, S 2020, ' Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes ', The Journal of Biological Chemistry, vol. 295, pp. 11803-11821 . https://doi.org/10.1074/jbc.RA120.012673
J Biol Chem

Staphylococcus aureus is among the leading causes of bacterial infections worldwide. The pathogenicity and establishment of S. aureus infections are tightly linked to its ability to modulate host immunity. Persistent infections are often associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabfeb22d43a8871b5e4869fa1a57255
https://doi.org/10.1074/jbc.ra120.012673

Comprehensive Genomic Investigation of Adaptive Mutations Driving the Low-Level Oxacillin Resistance Phenotype in Staphylococcus aureus

Autor: Stefano Giulieri, Ashleigh S Hayes, Ian R. Monk, Sarah L. Baines, Romain Guérillot, Natasha E Holmes, Diane Daniel, Torsten Seemann, Timothy P. Stinear, Wei Gao, Jason C Kwong, Norelle L Sherry, Benjamin P Howden, Peter B. Ward

Publikováno v: mBio, Vol 11, Iss 6 (2020)
mBio

The majority of Staphylococcus aureus strains causing human disease are methicillin-susceptible (MSSA) and can be treated with antistaphylococcal penicillins (such as oxacillin). While acquisition of the mec gene represents the main resistance mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1831f60bf656282e7ce608d9beaf7508
https://journals.asm.org/doi/10.1128/mBio.02882-20