Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ashleigh Morgan"'
Telomouse—a mouse model with human-length telomeres generated by a single amino acid change in RTEL1
Autor:
Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in
Externí odkaz:
https://doaj.org/article/1ec8f8f1cc1c4bba80901ee1adb464df
Autor:
Jinping Liu, Lan Cheng, Hilana El‐Mekkoussi, Charles‐Antoine Assenmacher, Michelle Y. Y. Lee, Danielle R. Jaffe, Kaisha Garvin‐Darby, Ashleigh Morgan, Elisabetta Manduchi, Jonathan Schug, Klaus H. Kaestner
Publikováno v:
Cancer Communications, Vol 43, Iss 6, Pp 706-710 (2023)
Externí odkaz:
https://doaj.org/article/5963c665bcf24e208a07aef245825a7a
Autor:
Jinping Liu, Lan Cheng, Hilana El-Mekkoussi, Michelle Lee, Danielle Jaffe, Kaisha Gavin-Darby, Ashleigh Morgan, Elisabetta Manduchi, Jonathan Schug, Klaus Kaestner
Combinatorial immunotherapy (CIT) has afforded patients with advanced HCC a potential for long-term survival. However, sustained responses are seen only in a minority of patients. Thus, there is an unmet need for precision modeling to differentiate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2c8abbcce807df86b16b368bd892d9f
https://doi.org/10.21203/rs.3.rs-1919053/v1
https://doi.org/10.21203/rs.3.rs-1919053/v1
Autor:
William Neil Cottrell, Christopher Freeman, Tobias Hegerty, Bernadette Chevalier, Ashleigh Morgan
Publikováno v:
International Journal of Pharmacy Practice. 28:534-540
Objective To pilot the Describing and Evaluating community Pharmacy practice to Improve patients' Care and Treatment (DEPICT) tool to determine its utility in collecting data about Australian community pharmacist activities and patient-related encoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0ab28023b8f4fd6e8409978df4af1d
https://doi.org/10.1111/ijpp.12620
https://doi.org/10.1111/ijpp.12620
Autor:
Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa Rowe, Yitzhak Reizel, Ashleigh Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati
Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b3b260fea454b269889d4ef860f3f7c
https://doi.org/10.1101/2021.06.06.447246
https://doi.org/10.1101/2021.06.06.447246
Autor:
Marcela Salazar Werner, Shweta Aras, Ashleigh Morgan, Nesteene J. Param, Jenny Greig, James M. Wilson
Publikováno v:
Cancer Research. 82:LB201-LB201
Breast cancer is the most common cause of brain metastases in women, affecting 15-30% of all patients. Despite the success of systemic Her2-targeted therapies, up to half of patients with Her2+ primary breast cancer develop breast cancer brain metast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a35bbd568bbf196a215caa5f754d601
https://doi.org/10.1158/1538-7445.am2022-lb201
https://doi.org/10.1158/1538-7445.am2022-lb201
Autor:
Maria, Fasolino, Gregory W, Schwartz, Abhijeet R, Patil, Aanchal, Mongia, Maria L, Golson, Yue J, Wang, Ashleigh, Morgan, Chengyang, Liu, Jonathan, Schug, Jinping, Liu, Minghui, Wu, Daniel, Traum, Ayano, Kondo, Catherine L, May, Naomi, Goldman, Wenliang, Wang, Michael, Feldman, Jason H, Moore, Alberto S, Japp, Michael R, Betts, Robert B, Faryabi, Ali, Naji, Klaus H, Kaestner, Golnaz, Vahedi
Publikováno v:
Nature metabolism. 4(2)
Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy insulin-producing beta cells. The aetiology of this complex disease is dependent on the interplay of multiple heterogeneous cell types in the pancreatic environment. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b5f8d12ae5f4166516ebd43ddaf124e
https://pubmed.ncbi.nlm.nih.gov/35228745
https://pubmed.ncbi.nlm.nih.gov/35228745
Autor:
Jason H. Moore, Golnaz Vahedi, Maria L. Golson, Michael R. Betts, Yue J. Wang, Gregory W. Schwartz, Jonathan Schug, Chengyang Liu, Minghui Wu, Ali Naji, Daniel Traum, Klaus H. Kaestner, Ayano Kondo, Ashleigh Morgan, Alberto Sada Japp, Naomi Goldman, Catherine Lee May, Robert B. Faryabi, Michael Feldman, Jinping Liu, Wenliang Wang, Maria Fasolino
Type 1 diabetes (T1D) is an autoimmune disease of only partially defined etiology in which immune cells destroy insulin-producing beta cells. Using single-cell transcriptomics and an advanced analytical strategy to assess pancreatic islets of T1D, au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1041185e816ab93959c99374371ad4c
https://doi.org/10.1101/2021.01.28.428598
https://doi.org/10.1101/2021.01.28.428598
Autor:
Klaus H. Kaestner, Meghan E. Kapp, Radhika Aramandla, Ashleigh Morgan, Chunhua Dai, Jeeyeon Cha, Luciana Mateus Gonçalves, Roland Stein, Shristi Shrestha, Maria Fasolino, Alvin C. Powers, Marcela Brissova, Regina Jenkins, Joana Almaça, Diane C. Saunders, Rita Bottino, Wenliang Wang, Katie C. Coate, Golnaz Vahedi
Publikováno v:
Cell Metabolism
bioRxiv
bioRxiv
Reports of new-onset diabetes and diabetic ketoacidosis in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2, the virus that causes COVID-19, is directly cytotoxic to pancreatic islet β cells. This would require binding and entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb5ce3a0694e5bf176caba4ac0f2ca3
Autor:
Joana Almaça, Chunhua Dai, Regina Jenkins, Diane C. Saunders, Rita Bottino, Ashleigh Morgan, Marcella Brissova, Maria Fasolino, Jeeyeon Cha, Luciana Mateus Gonçalves, Richard A. Stein, Klaus H. Kaestner, Shristi Shrestha, Alvin C. Powers, Weixin Wang, Golnaz Vahedi, Radhika Aramandla, Katie C. Coate, Meghan E. Kapp
Publikováno v:
Cell Metabolism
Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would require binding and entry of SARS-CoV-2 into β cells via co-expression of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c060f647f61c6e4952ea09c100375b2f
https://doi.org/10.1101/2020.08.31.275719
https://doi.org/10.1101/2020.08.31.275719