Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ashleigh King"'
Autor:
David M. Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K. Walia, Gemma L. Kelly, Carl R. Walkley, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1488-1499 (2016)
How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murin
Externí odkaz:
https://doaj.org/article/5452af9f1b96487f9e7a9fc15d95b041
Autor:
Sarah Clark, Janette B Myers, Ashleigh King, Radovan Fiala, Jiri Novacek, Grant Pearce, Jörg Heierhorst, Steve L Reichow, Elisar J Barbar
Publikováno v:
eLife, Vol 7 (2018)
Externí odkaz:
https://doaj.org/article/18e492cfab584fc69630a6263b204d40
Autor:
Rui Liu, Ashleigh King, Philippe Bouillet, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly incr
Externí odkaz:
https://doaj.org/article/514fc3cecd644e57a9a373fa7121daa6
Autor:
Ashleigh King, Lingli Li, David M Wong, Rui Liu, Rebecca Bamford, Andreas Strasser, David M Tarlinton, Jörg Heierhorst
Publikováno v:
PLoS Genetics, Vol 13, Iss 9, p e1007010 (2017)
Mechanistic differences in the development and function of adaptive, high-affinity antibody-producing B-2 cells and innate-like, "natural" antibody-producing B-1a cells remain poorly understood. Here we show that the multi-functional dynein light cha
Externí odkaz:
https://doaj.org/article/95951e948b51453495cae90a1a03f71b
Autor:
Lauren Gilstrap, Ronnie J. Zipkin, Jonathan Aaron Barnes, Ashleigh King, Alistair James O'Malley, Thomas A. Gaziano, Anna N.A. Tosteson
Publikováno v:
American Heart Journal. 250:23-28
In clinical trials, sacubitril/valsartan has demonstrated significant survival benefits compared to angiotensin converting enzyme inhibitors or angiotensin receptor blockers (ACEi/ARB). Whether older patients with heart failure with reduced ejection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec7dbfc53e409f9031e65205e742341
https://doi.org/10.1016/j.ahj.2022.04.007
https://doi.org/10.1016/j.ahj.2022.04.007
Publikováno v:
Nature Cell Biology. 24:51-61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6707d1379be53a7e15ee2591dd98fb9e
https://doi.org/10.1038/s41556-021-00812-9
https://doi.org/10.1038/s41556-021-00812-9
Autor:
Chris Miller-Rosales, Susan H. Busch, Ellen R. Meara, Ashleigh King, Thomas A. D’Aunno, Carrie H. Colla
Publikováno v:
Medical Care Research and Review. :107755872311626
Medications for opioid use disorder (MOUD) remain highly inaccessible despite demonstrated effectiveness. We examine the extent of screening for opioid use and availability of MOUD in a national cross-section of multi-physician primary care and multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647037d21c96063fe2fd4ec6b3a28b0b
https://doi.org/10.1177/10775587231162681
https://doi.org/10.1177/10775587231162681
Publikováno v:
The American journal of managed care. 27(12)
In the PARADIGM-HF trial, sacubitril/valsartan demonstrated a 20% reduction in mortality and heart failure hospitalization compared with standard angiotensin-converting enzyme inhibitor therapy. Despite this and a class I indication, drug diffusion h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fdb983fbb8d758ae151ea9c9891fbfd3
https://pubmed.ncbi.nlm.nih.gov/34889576
https://pubmed.ncbi.nlm.nih.gov/34889576
Publikováno v:
Circulation. 144
Introduction: Immune checkpoint inhibitors (ICI) have transformed care for cancer patients but can lead to immune-mediated toxicities in multiple organ systems. Cardiovascular toxicities are thought to be infrequent, but existing data likely underest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d184afe6b9fc6832560eb4c94a2067
https://doi.org/10.1161/circ.144.suppl_1.12534
https://doi.org/10.1161/circ.144.suppl_1.12534
The ASCIZ-DYNLL1 Axis Is Essential for TLR4-Mediated Antibody Responses and NF-κB Pathway Activation
Publikováno v:
Molecular and Cellular Biology
Toll-like receptors (TLRs) and interleukin-1 (IL-1) receptors regulate immune and inflammatory responses by activating the NF-κB pathway. Here, we report that B-cell‐specific loss of dynein light chain 1 (DYNLL1, LC8) or its designated transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbca35650227557f2144ffcd68ff2c40
https://pubmed.ncbi.nlm.nih.gov/34543116
https://pubmed.ncbi.nlm.nih.gov/34543116