Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ashlee K. Clark"'
Autor:
Gail P. Risbridger, Ashlee K. Clark, Laura H. Porter, Roxanne Toivanen, Andrew Bakshi, Natalie L. Lister, David Pook, Carmel J. Pezaro, Shahneen Sandhu, Shivakumar Keerthikumar, Rosalia Quezada Urban, Melissa Papargiris, Jenna Kraska, Heather B. Madsen, Hong Wang, Michelle G. Richards, Birunthi Niranjan, Samantha O’Dea, Linda Teng, William Wheelahan, Zhuoer Li, Nicholas Choo, John F. Ouyang, Heather Thorne, Lisa Devereux, Rodney J. Hicks, Shomik Sengupta, Laurence Harewood, Mahesh Iddawala, Arun A. Azad, Jeremy Goad, Jeremy Grummet, John Kourambas, Edmond M. Kwan, Daniel Moon, Declan G. Murphy, John Pedersen, David Clouston, Sam Norden, Andrew Ryan, Luc Furic, David L. Goode, Mark Frydenberg, Mitchell G. Lawrence, Renea A. Taylor
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The prognosis of castration-resistant prostate cancers remains dismal, but accurate preclinical models can lead to effective therapies. Here the Melbourne Urological Research Alliance establish prostate cancer patient-derived xenografts, use the tumo
Externí odkaz:
https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e1
Autor:
Arthe Raajendiran, Geraldine Ooi, Jackie Bayliss, Paul E. O’Brien, Ralf B. Schittenhelm, Ashlee K. Clark, Renea A. Taylor, Matthew S. Rodeheffer, Paul R. Burton, Matthew J. Watt
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1528-1540.e7 (2019)
Summary: Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene expression profiling, and metabolic and proteomic analyses,
Externí odkaz:
https://doaj.org/article/20f296ab02ac4555afaf35da238c3207
Autor:
Luc Furic, Ross D. Hannan, Richard B. Pearson, Gail P. Risbridger, Shahneen Sandhu, John Pedersen, Laura Porter, Ashlee K. Clark, Denis Drygin, Jennifer R. Devlin, Analia Lesmana, Helen B. Pearson, Donald P. Cameron, Eric Kusnadi, Richard J. Rebello
Supplementary Materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6e176d0b8065a4011f01aa7675fcd8
https://doi.org/10.1158/1078-0432.22463370
https://doi.org/10.1158/1078-0432.22463370
Autor:
Luc Furic, Ross D. Hannan, Richard B. Pearson, Gail P. Risbridger, Shahneen Sandhu, John Pedersen, Laura Porter, Ashlee K. Clark, Denis Drygin, Jennifer R. Devlin, Analia Lesmana, Helen B. Pearson, Donald P. Cameron, Eric Kusnadi, Richard J. Rebello
Fig S1: Generation and characterisation of an androgen-dependent Hi-MYC epithelial line from 5-month Hi-MYC lateral prostate adenocarcinoma. Fig S2: CX-6258 does not inhibit Ribosomal RNA transcription. Fig S3: CX-6258 does not induce p53, but does i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c566aad92e16fba9ef9b151ac8757f
https://doi.org/10.1158/1078-0432.22463373.v1
https://doi.org/10.1158/1078-0432.22463373.v1
Autor:
Luc Furic, Ross D. Hannan, Richard B. Pearson, Gail P. Risbridger, Shahneen Sandhu, John Pedersen, Laura Porter, Ashlee K. Clark, Denis Drygin, Jennifer R. Devlin, Analia Lesmana, Helen B. Pearson, Donald P. Cameron, Eric Kusnadi, Richard J. Rebello
Purpose: The MYC oncogene is frequently overexpressed in prostate cancer. Upregulation of ribosome biogenesis and function is characteristic of MYC-driven tumors. In addition, PIM kinases activate MYC signaling and mRNA translation in prostate cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc18c23a0926ccc3bd61472341b3193
https://doi.org/10.1158/1078-0432.c.6525384
https://doi.org/10.1158/1078-0432.c.6525384
Autor:
Mitchell G. Lawrence, Renea A. Taylor, Georgia B. Cuffe, Lisa S. Ang, Ashlee K. Clark, David L. Goode, Laura H. Porter, Clémentine Le Magnen, Nora M. Navone, Jack A. Schalken, Yuzhuo Wang, Wytske M. van Weerden, Eva Corey, John T. Isaacs, Peter S. Nelson, Gail P. Risbridger
Publikováno v:
Nature Reviews. Urology, 20, 371-384
Nature Reviews. Urology, 20, 6, pp. 371-384
Nature Reviews. Urology, 20, 6, pp. 371-384
Item does not contain fulltext Patient-derived xenografts (PDXs) are generated by engrafting human tumours into mice. Serially transplantable PDXs are used to study tumour biology and test therapeutics, linking the laboratory to the clinic. Although
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dff9e43370e7e5e999cf58ac4271e1d
http://hdl.handle.net/2066/293636
http://hdl.handle.net/2066/293636
Autor:
Melissa Papargiris, Natalie Lister, Hong Wang, Renea A. Taylor, Sam Norden, Shivakumar Keerthikumar, Andrew Ryan, Mahesh Iddawala, Michelle Richards, David L Goode, Mitchell G. Lawrence, Shomik Sengupta, Andrew Bakshi, Shahneen Sandhu, Jeremy Grummet, Laurence Harewood, John F. Ouyang, David Clouston, Heather Thorne, Luc Furic, Jeremy Goad, Rosalia Quezada Urban, Birunthi Niranjan, Nicholas Choo, Ashlee K. Clark, Carmel Pezaro, Samantha O'Dea, Daniel Moon, Declan G. Murphy, Lisa Devereux, Gail P. Risbridger, Jenna Kraska, Laura H Porter, Mark Frydenberg, Linda Teng, Rodney J. Hicks, Zhuoer Li, Heather B Madsen, David Pook, William Wheelahan, Arun Azad, John Pedersen, Roxanne Toivanen, John Kourambas, Edmond M. Kwan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and systematic evaluation of candidate therapies. The PDX collecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccde47e53c9f250c0616ced18c386363
https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e1
https://doaj.org/article/72ce33db9321419ba5cb98782c40a1e1
Autor:
David Pook, Mural investigators, Andrew Bakshi, Ashlee K. Clark, Renea A. Taylor, David L Goode, David Clouston, John Kourambas, Gail P. Risbridger, Laura H Porter, Mitchell G. Lawrence
Publikováno v:
The Journal of Pathology. 254:121-134
Amplifications of the androgen receptor (AR) occur in up to 80% of men with castration-resistant prostate cancer (CRPC). Recent studies highlighted that these amplifications not only span the AR gene but usually encompass a distal enhancer. This repr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8eda21e82d810499b72a74e4d9f949
https://doi.org/10.1002/path.5652
https://doi.org/10.1002/path.5652
Publikováno v:
The Prostate. 80:906-914
BACKGROUND: There is convincing evidence that men with advanced prostate cancer experience improved quality of life as a result of exercise therapy, although there is limited preclinical, and no clinical, data to directly support the notion that exer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2cf1fb449e6f762265db2a2b4ea8006
https://doi.org/10.1002/pros.24024
https://doi.org/10.1002/pros.24024
Autor:
Paul E. O'Brien, Renea A. Taylor, Ralf B. Schittenhelm, Jackie Bayliss, Matthew J. Watt, Paul Burton, Arthe Raajendiran, Ashlee K. Clark, Matthew S. Rodeheffer, Geraldine J. Ooi
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1528-1540.e7 (2019)
Summary: Adipocyte progenitor cells (APCs) provide the reservoir of regenerative cells to produce new adipocytes, although their identity in humans remains elusive. Using FACS analysis, gene expression profiling, and metabolic and proteomic analyses,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdccfeaaa3599236a94829d9b669e85d
http://www.sciencedirect.com/science/article/pii/S2211124719304656
http://www.sciencedirect.com/science/article/pii/S2211124719304656