Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ashlee Caldwell"'
Autor:
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood. However, targeting specific receptors mediating neuronal sen
Externí odkaz:
https://doaj.org/article/e6c2108661e44edea86c27c271ba7cfa
Autor:
Luke Grundy, Ashlee Caldwell, Amanda Lumsden, Ehsan Mohammadi, Gerhard Hannig, Beverley Greenwood Van-Meervald, Stuart M. Brierley
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition characterised by urinary urgency, frequency and pelvic pain, that significantly impacts the quality of life for ∼5% of women. Bladder sensation is coordinated by
Externí odkaz:
https://doaj.org/article/3ed6b1d2b169425e9c16bf71885169d7
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
The bladder is innervated by extrinsic afferents that project into the dorsal horn of the spinal cord, providing sensory input to the micturition centers within the central nervous system. Under normal conditions, the continuous activation of these n
Externí odkaz:
https://doaj.org/article/b5027ff4bf0c4e4ca38b1c4e651d69f6
Autor:
Andelain Erickson, Luke Grundy, Andrea M. Harrington, Joel Castro, Stuart M. Brierley, Ashlee Caldwell, Jessica Maddern
Publikováno v:
Pain. 162:227-242
Dyspareunia, also known as vaginal hyperalgesia, is a prevalent and debilitating symptom of gynaecological disorders such as endometriosis and vulvodynia. Despite this, the sensory pathways transmitting nociceptive information from female reproductiv
Autor:
Ashlee Caldwell, Andelain Erickson, Andrea M. Harrington, Luke Grundy, Sonia Garcia Caraballo, Gudrun Schober, Stuart M. Brierley, Joel Castro
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F298-F314
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for hypersensitivity of bladder-innervating sensory neurons. The inflammator
Autor:
Andrea M. Harrington, Vasiliki Staikopoulos, Luke Grundy, Nick J. Spencer, Vladimir P. Zagorodnyuk, Ashlee Caldwell, Joel Castro, Stuart M. Brierley, Simon J. H. Brookes
Publikováno v:
Pain. 160:793-804
Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic reflexes necessary for maintaining continence are coordinated with pathways involved in sensatio
Autor:
Joel Castro, Ashlee Caldwell, Sonia Garcia-Caraballo, Luke Grundy, Xinzhong Dong, David Grundy, Nick J. Spencer, Stuart M. Brierley, Andrea M. Harrington
Publikováno v:
J Neurosci
Understanding the sensory mechanisms innervating the bladder is paramount to developing efficacious treatments for chronic bladder hypersensitivity conditions. The contribution of Mas-gene-related G protein-coupled receptors (Mrgpr) to bladder signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00ffa697b8e8de1de90d9809c262810
https://europepmc.org/articles/PMC8084315/
https://europepmc.org/articles/PMC8084315/
Autor:
Joel, Castro, Jessica, Maddern, Andelain, Erickson, Ashlee, Caldwell, Luke, Grundy, Andrea M, Harrington, Stuart M, Brierley
Publikováno v:
Pain. 162(1)
Dyspareunia, also known as vaginal hyperalgesia, is a prevalent and debilitating symptom of gynaecological disorders such as endometriosis and vulvodynia. Despite this, the sensory pathways transmitting nociceptive information from female reproductiv
Autor:
Luke, Grundy, Ashlee, Caldwell, Sonia, Garcia Caraballo, Andelain, Erickson, Gudrun, Schober, Joel, Castro, Andrea M, Harrington, Stuart M, Brierley
Publikováno v:
Am J Physiol Renal Physiol
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a common chronic pelvic disorder with sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for hypersensitivity of bladder-innervating sensory neurons. The inflammator
Autor:
Andrea M. Harrington, Joel Castro, Andelain Erickson, Luke Grundy, Sonia Garcia-Caraballo, Annemie Deiteren, Stuart M. Brierley, Ashlee Caldwell
Publikováno v:
The Journal of Physiology. 596:785-807
Chronic visceral pain, altered motility and bladder dysfunction are common, yet poorly managed symptoms of functional and inflammatory disorders of the gastrointestinal and urinary tracts. Recently, numerous human channelopathies of the voltage-gated