Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ashkan Bigdeli"'
Publikováno v:
Journal of Pathology Informatics, Vol 13, Iss , Pp 100089- (2022)
Copy number variants (CNVs) comprise a class of mutation which includes deletion, duplication, or amplification events that range in size from smaller than a single-gene or exon, to the size of a full chromosome. These changes can affect gene express
Externí odkaz:
https://doaj.org/article/56815b941019465ab79bb33470513400
Autor:
Robert B. Faryabi, Martin Carroll, Mingyao Li, Alexander E. Perl, Jennifer J.D. Morrissette, Anne W. Lehman, Rachel Astles, Ashkan Bigdeli, Priya Velu, Yeqiao Zhou, Bryan Manning, Gregory W. Schwartz
Purpose:Recurrent internal tandem duplication (ITD) mutations are observed in various cancers including acute myeloid leukemia (AML), where ITD mutations in tyrosine kinase receptor FLT3 are associated with poor prognostic outcomes. Several FLT3 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a964eba9772882f1777e29f77045382
https://doi.org/10.1158/1078-0432.c.6529170.v1
https://doi.org/10.1158/1078-0432.c.6529170.v1
Autor:
Robert B. Faryabi, Martin Carroll, Mingyao Li, Alexander E. Perl, Jennifer J.D. Morrissette, Anne W. Lehman, Rachel Astles, Ashkan Bigdeli, Priya Velu, Yeqiao Zhou, Bryan Manning, Gregory W. Schwartz
Figure S1: Characterization of FLT3-ITD clones in the FLT3i cohort. Table S1: Confusion matrix of HeatITup and genetic reviewers manual annotation for sequences in Figure 3. Table S2: Univariate Cox regression analyses for the FLT3-ITD-positive UPENN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9279bb40fe6f6d11afa773825201cf8
https://doi.org/10.1158/1078-0432.22475784
https://doi.org/10.1158/1078-0432.22475784
Publikováno v:
Advances in Molecular Pathology. 4:199-204
Autor:
Christopher M. Sande, Rui Wu, Guang Yang, Robyn T. Sussman, Ashkan Bigdeli, Chase Rushton, Akshay Chitturi, Jay Patel, Philippe Szankasi, Jennifer J.D. Morrissette, Megan S. Lim, Kojo S.J. Elenitoba-Johnson
Publikováno v:
The Journal of molecular diagnostics : JMD.
Evaluation of suspected myeloid neoplasms involves testing for recurrent, diagnostically and therapeutically relevant genetic alterations. Current molecular testing requires multiple technologies, different domains of expertise, and unconnected workf
Autor:
Tristan L. Lim, David B. Lieberman, Adam R. Davis, Ryan Hausler, Ashkan Bigdeli, Yimei Li, Jacquelyn Powers, Regeneron Genetics Center, Shannon A. Carty, Katherine L. Nathanson, Adam Bagg, Elizabeth O. Hexner, Kara N. Maxwell, Jennifer J.D. Morrissette, Daria V. Babushok
Publikováno v:
Blood. 136:2-4
Germline mutations in the shelterin component protection of telomeres 1 (POT1) were recently found to be associated with familial chronic lymphocytic leukemia (CLL), melanoma, glioma, and several other familial cancer syndromes. The role of POT1 muta
Autor:
Yeqiao Zhou, Jelena Petrovic, Jingru Zhao, Wu Zhang, Ashkan Bigdeli, Zhen Zhang, Shelley L. Berger, Warren S. Pear, Robert B. Faryabi
Publikováno v:
Mol Cell
Chromatin misfolding has been implicated in cancer pathogenesis; yet, its role in therapy resistance remains unclear. Here, we systematically integrated sequencing and imaging data to examine the spatial and linear chromatin structures in targeted th
Autor:
Anna Raper, Katherine L. Nathanson, Yimei Li, Daria V. Babushok, Adam R. Davis, Elizabeth O. Hexner, Kara N. Maxwell, Jacquelyn Powers, Tristan L. Lim, Adam Bagg, Shannon A. Carty, Alison W. Loren, Ashkan Bigdeli, David B. Lieberman, Jennifer J.D. Morrissette, Ryan Hausler
Publikováno v:
Leukemia
Autor:
Daniel I. Hoffman, Stephen J Bagley, Zev A. Binder, Ashkan Bigdeli, Jennifer J.D. Morrissette, Kalil G. Abdullah, Makayla McCoskey, MacLean Nasrallah, Donald M. O'Rourke, Arati Desai, Steven Brem
Publikováno v:
Journal of Neuro-Oncology. 145:321-328
Young adults with isocitrate-dehydrogenase wild-type (IDH-WT) glioblastoma (GBM) represent a rare, understudied population compared to pediatric high-grade glioma, IDH-mutant GBM, or IDH-WT GBM in older patients. We aimed to explore the prognostic im
Autor:
Martin Carroll, Rachel Astles, Robert B. Faryabi, Jennifer J.D. Morrissette, Yeqiao Zhou, Priya Velu, Alexander E. Perl, Ashkan Bigdeli, Mingyao Li, Gregory W. Schwartz, Bryan Manning, Anne Lehman
Publikováno v:
Clinical Cancer Research. 25:573-583
Purpose: Recurrent internal tandem duplication (ITD) mutations are observed in various cancers including acute myeloid leukemia (AML), where ITD mutations in tyrosine kinase receptor FLT3 are associated with poor prognostic outcomes. Several FLT3 inh