Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Ashish Sethi"'
Autor:
Priyanka Vinod Bansal, Kavita Raj, Neha Gupta, Dhara Dwivedi, Ashish Sethi, Nitin Prabhakar, Ramanpal Singh Makkad
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss Suppl 3, Pp S2159-S2161 (2024)
Background: A chronic inflammatory illness known as oral lichen planus (OLP) affects approximately 1–2% of adults, with middle-aged women having a higher prevalence than men. One clinical endocrine condition that primary care doctors frequently see
Externí odkaz:
https://doaj.org/article/7e2af146e37242a8abf99ac2763a3880
Autor:
Seyed Mohammad Ghafoori, Ashish Sethi, Gayle F. Petersen, Mohammad Hossein Tanipour, Paul R. Gooley, Jade K. Forwood
Publikováno v:
Cells, Vol 13, Iss 14, p 1202 (2024)
SOX proteins are a family of transcription factors (TFs) that play critical functions in sex determination, neurogenesis, and chondrocyte differentiation, as well as cardiac, vascular, and lymphatic development. There are 20 SOX family members in hum
Externí odkaz:
https://doaj.org/article/c1a1ba8566ae474ca098ef2907183cd9
Autor:
Sepideh Valimehr, Ashish Sethi, Manjari Shukla, Sudipta Bhattacharyya, Mohsen Kazemi, Isabelle Rouiller
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 737 (2023)
p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+ ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases and cancer. p97 performs a variety of functions in the cell and fa
Externí odkaz:
https://doaj.org/article/54ef8b9b80094eeebc20a33126960bb5
Autor:
Klára Kirsch, András Zeke, Orsolya Tőke, Péter Sok, Ashish Sethi, Anna Sebő, Ganesan Senthil Kumar, Péter Egri, Ádám L. Póti, Paul Gooley, Wolfgang Peti, Isabel Bento, Anita Alexa, Attila Reményi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ATF2 transcription factor is phosphorylated by different mitogen-activated protein (MAP) kinases. Here, the authors show that the functionally distinct MAP kinases JNK and p38 control ATF2 through different binding sites and differential phosphor
Externí odkaz:
https://doaj.org/article/8e3a384b4b1a49a98424465168b5b1a6
Autor:
Jingyu Zhan, Angela R Harrison, Stephanie Portelli, Thanh Binh Nguyen, Isshu Kojima, Siqiong Zheng, Fei Yan, Tatsunori Masatani, Stephen M Rawlinson, Ashish Sethi, Naoto Ito, David B Ascher, Gregory W Moseley, Paul R Gooley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009729 (2021)
Rabies virus phosphoprotein (P protein) is a multifunctional protein that plays key roles in replication as the polymerase cofactor that binds to the complex of viral genomic RNA and the nucleoprotein (N protein), and in evading the innate immune res
Externí odkaz:
https://doaj.org/article/04e7c1bd948047038f0c27a6d86a6c67
Autor:
Bradley L. Hoare, Shoni Bruell, Ashish Sethi, Paul R. Gooley, Michael J. Lew, Mohammed A. Hossain, Asuka Inoue, Daniel J. Scott, Ross A.D. Bathgate
Publikováno v:
iScience, Vol 11, Iss , Pp 93-113 (2019)
Summary: The peptide hormone H2 relaxin has demonstrated promise as a therapeutic, but mimetic development has been hindered by the poorly understood relaxin receptor RXFP1 activation mechanism. H2 relaxin is hypothesized to bind to two distinct ECD
Externí odkaz:
https://doaj.org/article/106ae93fb3814699bbd1551cc5a6f606
Autor:
Shoni Bruell, Ashish Sethi, Nicholas Smith, Daniel J. Scott, Mohammed Akhter Hossain, Qing-Ping Wu, Zhan-Yun Guo, Emma J. Petrie, Paul R. Gooley, Ross A. D. Bathgate
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Relaxin family peptide receptor 2 (RXFP2) is a GPCR known for its role in reproductive function. It is structurally related to the human relaxin receptor RXFP1 and can be activated by human gene-2 (H2) relaxin as well as its cognate ligand i
Externí odkaz:
https://doaj.org/article/8eaad5d63dd34da1a869adfafa703bc1
Autor:
Md. Alamgir Hossain, Florence Larrous, Stephen M. Rawlinson, Jingyu Zhan, Ashish Sethi, Youssef Ibrahim, Maria Aloi, Kim G. Lieu, Yee-Foong Mok, Michael D.W. Griffin, Naoto Ito, Toyoyuki Ose, Hervé Bourhy, Gregory W. Moseley, Paul R. Gooley
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1934-1945.e8 (2019)
Summary: To evade immunity, many viruses express interferon antagonists that target STAT transcription factors as a major component of pathogenesis. Because of a lack of direct structural data, these interfaces are poorly understood. We report the st
Externí odkaz:
https://doaj.org/article/fb90375ce8c54d2b8e0643781f732fb3
Autor:
Ashish Sethi, Shoni Bruell, Nitin Patil, Mohammed Akhter Hossain, Daniel J. Scott, Emma J. Petrie, Ross A. D. Bathgate, Paul R. Gooley
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
The mechanism by which relaxin activates the relaxin family peptide receptor-1 is poorly understood. Here, Sethi et al.identify a relaxin binding site in an extracellular linker between the LDLa and LRR domains and propose that relaxin binding stabil
Externí odkaz:
https://doaj.org/article/54b25db5eb6645b78a4e6e1855d32598
Publikováno v:
Indian Journal of Anaesthesia, Vol 58, Iss 6, Pp 719-725 (2014)
Background and Aims: Sevoflurane, a popular inhalational anaesthetic for children, has been associated with significant emergence agitation in the recovery phase. This study was intended to compare two doses of caudal clonidine added to ropivacaine 0
Externí odkaz:
https://doaj.org/article/c0853db6574e4da48ea09c9d07aa5421