Výsledky vyhledávání - "Ashish P. Keche"

Akademický článek

Synthesis and anti-inflammatory and antimicrobial activities of some novel 2-methylquinazolin-4(3H)-one derivatives bearing urea, thiourea and sulphonamide functionalities

Autor: Ashish P. Keche, Vandana M. Kamble

Publikováno v: Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1522-1531 (2019)

A variety of novel 2-methylquinazolin-4(3H)-one derivatives (1–29) bearing urea, thiourea and sulphonamide functionalities at position 3 of biological interest have been synthesized and screened for their anti-inflammatory (TNF-α and IL-6) and ant

Externí odkaz: https://doaj.org/article/89d9085d615f4435933c5b5f986d11b7

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Synthesis and biological evaluation of novel 2′,4′,5′-trimethoxyflavonol derivatives as anti-inflammatory and antimicrobial agents

Autor: Mahendra J. Pawar, Vandana M. Kamble, Girish D. Hatnapure, Rajesh H. Tale, Ashish P. Keche, Atish H. Rodge, Satish S. Birajdar

Publikováno v: Medicinal Chemistry Research. 23:461-470

A series of novel 3-hydroxy-2-(2,4,5-trimethoxyphenyl)-4H-chromen-4-one (flavonol) derivatives (2a–u) of biological interest have been prepared via CLAISEN–SCHMIDT condensation followed by ALGAR–FLYNN–OYAMADA reaction and to search for the po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae0dcf2c9c5c9cd2ca33a0a63976f251
https://doi.org/10.1007/s00044-013-0651-z

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Lead optimization of isocytosine-derived xanthine oxidase inhibitors

Autor: Usha Ghosh, Smriti Khanna, Asha Kulkarni-Almeida, Ankita Srivastava, Komal Bajaj, Chandrika B-Rao, Prashant Tannu, Ashish P. Keche, Kumar V.S. Nemmani, Pranay Shah, Sandeep Burudkar, Rajiv Sharma, Yogesh Suresh Ahire, H. Sivaramakrishnan, Amol Dixit, Anagha Damre, Nitin J. Deshmukh

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:834-838

We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good in vivo efficacy when administered intraperitoneall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866072cdc89ac5f3a8aa3b0daba5e338
https://doi.org/10.1016/j.bmcl.2012.11.057

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Synthesis, anti-inflammatory and antimicrobial evaluation of novel N1-(quinolin-4yl)ethane-1,2-diamine phenyl urea derivatives

Autor: Atish H. Rodge, Vandana M. Kamble, Ashish P. Keche, Girish D. Hatnapure, Satish S. Birajdar, Rajesh H. Tale

Publikováno v: Medicinal Chemistry Research. 22:1480-1487

A series of substituted N-(quinolin-4-yl)ethanediamine phenyl urea derivatives of biological interest were prepared by sequential quinoline synthesis, chlorination, and substitution reaction followed by reaction of resulting amine with different aryl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::382cf6ee0fc3e5fe1db3651aebfb0ac6
https://doi.org/10.1007/s00044-012-0144-5

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Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits

Autor: Rajiv Sharma, Smriti Khanna, Umakant Ashok Bahirat, Asha Kulkarni-Almeida, Pranay Shah, Amol Dixit, Kamlesh V. Katkar, Kumar V.S. Nemmani, Ashish P. Keche, H. Sivaramakrishnan, Vaidehi Korde, Chandrika B-Rao, Ankita Srivastava, Nitin J. Deshmukh, Manoja K. Brahma, Lalit S. Doshi, Usha Ghosh

Publikováno v: Bioorganic & Medicinal Chemistry. 20:2930-2939

In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical trials with uricosurics have demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f36cd3ab923720ed9f3033ad523d3d5
https://doi.org/10.1016/j.bmc.2012.03.019

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The synthesis, anti-inflammatory and antimicrobial activity evaluation of novel thioanalogs of 3,4-dihydrothiopyrimidin-2(1H)-one derivatives of N-aryl urea

Autor: Ashish P. Keche, Girish D. Hatnapure, Rajesh H. Tale, Atish H. Rodge, Rajendra P. Pawar, Kalpana M. Patil

Publikováno v: Medicinal Chemistry Research. 21:4252-4260

A series of novel thiourea analogs of 3,4-dihydropyrimidin-2(1-H)-one derivatives of biological interest were prepared by sequential Bigineli’s reaction, reduction followed by reaction of resulting amine with different arylisothiocynates. All the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be5e6d4e538d8a8da5c33a6d33882892
https://doi.org/10.1007/s00044-011-9943-3

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Mild and efficient syntheses of diverse isoindolinones from ortho-phthaldehydic acid methylthiomethyl ester

Autor: Rituparna Bhattacharyya, Ashish P. Keche, Usha Ghosh

Publikováno v: Tetrahedron. 66:2148-2155

A mild and efficient method for the synthesis of diverse isoindolinones from o -phthaldehydic acid methylthiomethyl ester and aliphatic/aromatic amines has been developed. A number of nucleophiles including a hydride ion were successfully added to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::508a894b99e343f579bc15e0365a43d9
https://doi.org/10.1016/j.tet.2010.01.070

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Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent

Autor: Ashish P. Keche, Girish D. Hatnapure, Satish S. Birajdar, Rajesh H. Tale, Atish H. Rodge, Vandana M. Kamble

Publikováno v: Bioorganicmedicinal chemistry letters. 22(20)

A series of novel 6-methoxy-2-(piperazin-1-yl)-4 H -chromen-4-one and 5,7-dimethoxy-2-(piperazin-1-ylmethyl)-4 H -chromen-4-one derivatives of biological interest were prepared and screened for their pro-inflammatory cytokines (TNF-α and IL-6) and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a9d4b059b53d0ebce377a9618ecec4
https://pubmed.ncbi.nlm.nih.gov/22981334

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Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia

Publikováno v: Bioorganicmedicinal chemistry letters. 22(24)

Structure-activity relationship studies were carried out for lead generation following structure-guided design approach from an isocytosine scaffold identified earlier for xanthine oxidase inhibition. A 470-fold improvement in in vitro IC(50) was obt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffce995a86667308764db679b25321b
https://pubmed.ncbi.nlm.nih.gov/23122864

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ChemInform Abstract: The Novel 3,4-Dihydropyrimidin-2(1H)-one Urea Derivatives of N-Aryl Urea: Synthesis, Antiinflamatory, Antibacterial and Antifungal Activity Evaluation

Autor: Atish H. Rodge, Girish D. Hatnapure, Rajesh H. Tale, Ashish P. Keche

Publikováno v: ChemInform. 42

Compounds (IIg) and (IIh) are found to exhibit promising antiinflammatory activities, whereas compounds (IIa)—(IIf) show promising antimicrobial activity against selected pathogenic bacteria and fungi.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::666931040dbce53d1f3734bd73287c41
https://doi.org/10.1002/chin.201147153

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