Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ashish P Vartak"'
Autor:
Ashish P Vartak, Swati S More
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 10, Pp 2113-2114 (2024)
Externí odkaz:
https://doaj.org/article/c67d9f15c2a4465a98f9b48abef947a7
Publikováno v:
Chemical Research in Toxicology. 30:777-784
Ψ-Glutathione (ψ-GSH) is an orally bioavailable and metabolism-resistant glutathione analogue that has been shown previously to substitute glutathione in most of its biochemical roles. Described here in its entirety is the preclinical evaluation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9160b863f5afff8f5c6a60282cb6a4
https://doi.org/10.1021/acs.chemrestox.6b00291
https://doi.org/10.1021/acs.chemrestox.6b00291
Autor:
Ashish P. Vartak
Publikováno v:
Expert Opinion on Drug Discovery. 9:1371-1377
Lofexidine is one therapeutic option used for treating the onslaught of sympathetic outflow that typically commences upon induction of opiate withdrawal. It was approved for opiate detoxification in the UK, most of EU, and a select few countries worl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd953525a431c723b817513f776b7a4
https://doi.org/10.1517/17460441.2014.962995
https://doi.org/10.1517/17460441.2014.962995
Publikováno v:
ACS Chemical Neuroscience. 4:330-338
Pathologically high brain levels of reactive dicarbonyls such as methylglyoxal or glyoxal initiate processes that lead ultimately to neurodegeneration, presented clinically as Alzheimer's disease and other cognitive or motor impairment disorders. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cede8f415dce87bdc0fc2175243f7b7
https://doi.org/10.1021/cn3001679
https://doi.org/10.1021/cn3001679
Autor:
Linda P. Dwoskin, Peter A. Crooks, Ashish P. Vartak, John P. Culver, Guangrong Zheng, David B. Horton, Fang Zheng
Publikováno v:
Current Topics in Medicinal Chemistry. 11:1103-1127
The vesicular monoamine transporter-2 (VMAT2) is considered as a new target for the development of novel therapeutics to treat psychostimulant abuse. Current information on the structure, function and role of VMAT2 in psychostimulant abuse are presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52024310ae27f75d065fdd3f2188ca81
https://doi.org/10.2174/156802611795371332
https://doi.org/10.2174/156802611795371332
Autor:
Ashish P. Vartak, Peter A. Crooks, K. Grant Taylor, William M. Pierce, Ned B. Smith, Shama Nasim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7450-7453
A series of 3- O -phosphorylated analogs ( 4 – 10 ) of a novel bone-targeting estradiol analog ( 3 ) were synthesized after a thorough study of the reaction of 3 with a selection of phosphoryl chlorides under a variety of reaction conditions. Evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ee7db9cf08739fda7fbbd0f588cabc
https://doi.org/10.1016/j.bmcl.2010.10.023
https://doi.org/10.1016/j.bmcl.2010.10.023
Autor:
Emily D. Denehy, Joshua S. Beckmann, David B. Horton, Peter A. Crooks, Kiran B. Siripurapu, Michael T. Bardo, Linda P. Dwoskin, Ashish P. Vartak, Justin R. Nickell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 335:841-851
Both lobeline and lobelane attenuate methamphetamine self-administration in rats by decreasing methamphetamine-induced dopamine release via interaction with vesicular monoamine transporter-2 (VMAT2). A novel derivative of nor-lobelane, cis-2,5-di-(2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b463ecbee8e902b96594f7319b096954
https://doi.org/10.1124/jpet.110.172742
https://doi.org/10.1124/jpet.110.172742
Publikováno v:
Synthetic Communications. 40:772-781
An improved, highly scalable methodology for the multigram-scale preparation of an important synthon, 17-β-(2-carboxyethyl)-1,3,5(10)-estratriene, is described. Previous approaches have failed to provide useful quantities of the analytically pure pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab72b090bc40813bc96fc13653ba2570
https://doi.org/10.1080/00397910903013796
https://doi.org/10.1080/00397910903013796
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:431-434
The synthesis of the d4-forms of rac- and R-lofexidine was accomplished. Two methods are described; one method is a two-step synthesis of rac-d4-lofexidine from 2-chloropropionitrile, the second method is a three-step preparation of R-d4-lofexidine i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04b6f29255cfcabb2c5cfeac8fd69d49
https://doi.org/10.1002/jlcr.1655
https://doi.org/10.1002/jlcr.1655
Autor:
Peter A. Crooks, Ashish P. Vartak
Publikováno v:
Organic Process Research & Development. 13:415-419
A scalable and high-yielding synthetic route toward pure enantiomers of the α2-adrenergic agonist, lofexidine hydrochloride, is presented. Salient features include a rapid one-pot amide alkylation-imidazoline formation sequence on the carboxamide fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32cf3a4cbe0c304238a63f0abdce95c2
https://doi.org/10.1021/op8002689
https://doi.org/10.1021/op8002689