Reversible cardiac disease features in an inducible CUG repeat RNA–expressing mouse model of myotonic dystrophy

Autor: Ashish N. Rao, Hannah M. Campbell, Xiangnan Guan, Tarah A. Word, Xander H.T. Wehrens, Zheng Xia, Thomas A. Cooper

Publikováno v: JCI Insight, Vol 6, Iss 5 (2021)

Myotonic dystrophy type 1 (DM1) is caused by a CTG repeat expansion in the DMPK gene. Expression of pathogenic expanded CUG repeat (CUGexp) RNA causes multisystemic disease by perturbing the functions of RNA-binding proteins, resulting in expression

Externí odkaz: https://doaj.org/article/57ad09e152f94a3589084046d23de525

BNANC Gapmers Revert Splicing and Reduce RNA Foci with Low Toxicity in Myotonic Dystrophy Cells

Autor: Kassie S. Manning, Thomas A. Cooper, Miguel Castro, Ashish N. Rao

Publikováno v: ACS Chemical Biology. 12:2503-2509

Myotonic dystrophy type 1 (DM1) is a multisystemic disease caused by an expanded CTG repeat in the 3′ UTR of the dystrophia myotonica protein kinase (DMPK) gene. Short, DNA-based antisense oligonucleotides termed gapmers are a promising strategy to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dac0bad33c6271a64eb3d6b971a5316b
https://doi.org/10.1021/acschembio.7b00416

Release of Neutrophil Extracellular Traps by Neutrophils Stimulated With Antiphospholipid Antibodies: A Newly Identified Mechanism of Thrombosis in the Antiphospholipid Syndrome

Autor: Paula L. Bockenstedt, Travis J. Gould, Diego F. Hernández-Ramírez, Srilakshmi Yalavarthi, Antonio R. Cabral, Carlos A. Núñez-Álvarez, Patricia C. Liaw, Alexandra E. Morris, Ashish N. Rao, Levi F. Mazza, Jason S. Knight

Publikováno v: Arthritis & Rheumatology. 67:2990-3003

Objective Antiphospholipid antibodies (aPL), especially those targeting β2-glycoprotein I (β2GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09b347ed43f2dea8eb9b723dbb4c9e6a
https://doi.org/10.1002/art.39247

Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?

Autor: Ashish N. Rao, Jason S. Knight, Nayef M. Kazzaz

Thrombotic events, both arterial and venous, are a major health concern worldwide. Further, autoimmune diseases, such as systemic lupus erythematosus, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and antiphospholipid syndrome, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d848387710eabcb2f3b19520c52eecc
https://europepmc.org/articles/PMC4691810/

Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases?

Autor: Rao AN; Ashish N Rao, Nayef M Kazzaz, Jason S Knight, Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5680, United States., Kazzaz NM; Ashish N Rao, Nayef M Kazzaz, Jason S Knight, Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5680, United States., Knight JS; Ashish N Rao, Nayef M Kazzaz, Jason S Knight, Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-5680, United States.

Publikováno v: World journal of cardiology [World J Cardiol] 2015 Dec 26; Vol. 7 (12), pp. 829-42.