Výsledky vyhledávání - "Ashish M. Dhote"

Identification of structural scaffold from interbioscreen (IBS) database to inhibit 3CLpro, PLpro, and RdRp of SARS-CoV-2 using molecular docking and dynamic simulation studies

Autor: Vikas R. Patil, Ashish M. Dhote, Rina Patil, Nikhil D. Amnerkar, Deepak K. Lokwani, Vinod G. Ugale, Nitin B. Charbe, Sandip D. Firke, Prashant Chaudhari, Sapan K. Shah, Chetan H. Mehta, Usha Y. Nayak, Saurabh C. Khadse

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86cc8c81533737474ca1dc6ce50a796f
https://doi.org/10.1080/07391102.2023.2175377

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Strategic analyses to identify key structural features of antiviral/antimalarial compounds for their binding interactions with 3CLpro, PLpro and RdRp of SARS-CoV-2: in silico molecular docking and dynamic simulation studies

Autor: Nitin B Charbe, Vinod G. Ugale, Bhoomendra A. Bhongade, Deepak K. Lokwani, Vikas R. Patil, Saurabh C. Khadse, Nikhil D. Amnerkar, Ashish M Dhote

Publikováno v: Journal of Biomolecular Structure and Dynamics. 40:11914-11931

Severe acute respiratory syndrome coronavirus (SARS-CoV-2), a novel member of the betacoronavirus family is a single-stranded RNA virus that has spread worldwide prompting the World Health Organization to declare a global pandemic. This creates an al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c662888835ccb63cbaeacae8967b3ad0
https://doi.org/10.1080/07391102.2021.1965912

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Natural Antidiabetic Agents: Molecular Docking Study using the Extra Precision Method

Autor: Sanjay J. Surana, Atul A. Shirkhedkar, Sandip D. Firke, Ashish M Dhote, Ravindra R. Patil

Publikováno v: Letters in Drug Design & Discovery. 18:143-171

Background:Diabetes mellitus (DM) is the most severe, chronic metabolic disorder with abnormally elevated concentration of plasma glucose levels, leading to significant complications, such as diabetic neuropathy, retinopathy, and cardiovascular illne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ee70ad6925482f4f3a6817aa880fb25
https://doi.org/10.2174/1570180817999200925164325

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Strategic analyses to identify key structural features of antiviral/antimalarial compounds for their binding interactions with 3CLpro, PLpro and RdRp of SARS-CoV-2

Autor: Ashish M, Dhote, Vikas R, Patil, Deepak K, Lokwani, Nikhil D, Amnerkar, Vinod G, Ugale, Nitin B, Charbe, Bhoomendra A, Bhongade, Saurabh C, Khadse

Publikováno v: Journal of biomolecular structuredynamics. 40(22)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0db668147c918cb3f688e1d23e32272c
https://pubmed.ncbi.nlm.nih.gov/34431452

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GluN2B/N-methyl-D-aspartate Receptor Antagonists: Advances in Design, Synthesis, and Pharmacological Evaluation Studies

Autor: Ashish M Dhote, Vinod G. Ugale, Atul A. Shirkhedkar, P. Narayana Reddy, Rushikesh Narwade, Saurabh C. Khadse

Publikováno v: CNSneurological disorders drug targets. 20(9)

Selective GluN2B/N-methyl-D-aspartate receptor (NMDAR) antagonists have exposed their clinical effectiveness in a cluster of neurodegenerative diseases, such as epilepsy, Alzheimer’s disease, Parkinson’s disease, pain, and depression. Hence, GluN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fea8aa44b694082332f611a4922734
https://pubmed.ncbi.nlm.nih.gov/33687902

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Pharmaceutical Analytical Profile for Novel SGL-2 Inhibitor: Dapagliflozin

Autor: Atul A. Shirkhedkar, Mangesh R. Patil, Shweta S Sharma, Preeti S. Bobade, Saurabh B. Ganorkar, Ashish M Dhote

Publikováno v: Critical reviews in analytical chemistry. 51(8)

Dapagliflozin (DPG) is a novel drug from class of sodium glucose co-transporter 2 (SGL-2) inhibitors which has been evolved as profound treatment option for the type-2diabetes mellitus (T2DM). Considering the severity of the disease the drug is of cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29085e6590d7fabf2414d712b09377f7
https://pubmed.ncbi.nlm.nih.gov/32544345

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Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and in-silico ADME evaluation

Autor: Nitin Charbe, Vikas R. Patil, Deepak K. Lokwani, Vivekanand A. Chatpalliwar, Ashish M Dhote, Vinod G. Ugale, Saurabh C. Khadse, Krushna S. Dighole, Nikhil D. Amnerkar

Publikováno v: Journal of Molecular Structure. 1222:128916

A series of hetero-substituted sulphonamido-benzamide derivatives which can activate glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay and in-vivo following oral glucose tolerance test (OGTT) assays. All the mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40d598f2dd201ba3c2cf043acf0e8775
https://doi.org/10.1016/j.molstruc.2020.128916

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