Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ashish L. Sarode"'
Publikováno v:
AAPS PharmSciTech. 17:1468-1476
The interactions with and effects of five chemically distinct, bioactive phenolic compounds on the lipid bilayers of model dipalmitoylphosphatidylcholine (DPPC) liposomes were investigated. Complementary analytical techniques, including differential
Autor:
Navnit Hargovindas Shah, Raman Mahadevan Iyer, Harpreet K. Sandhu, Fumie Tanno, Ashish L. Sarode, Sakae Obara
Publikováno v:
Carbohydrate Polymers. 101:146-153
HPMCAS is a widely used polymer in the pharmaceutical industry as an excipient. In this work, the physicochemical stability of HPMCAS was investigated for hot melt extrusion (HME) application. The reduction in zero rate viscosity (η0) of the polymer
Publikováno v:
Molecular Pharmaceutics. 10:3665-3675
Hot melt extrudates (HMEs) of indomethacin (IND) with Eudragit EPO and Kollidon VA 64 and those of itraconazole (ITZ) with HPMCAS-LF and Kollidon VA 64 were manufactured using a Leistritz twin screw extruder. The milled HMEs were stored at controlled
Publikováno v:
AAPS PharmSciTech. 14:151-159
Hydroxypropylcellulose (HPC)-SL and -SSL, low-viscosity hydroxypropylcellulose polymers, are versatile pharmaceutical excipients. The utility of HPC polymers was assessed for both dissolution enhancement and sustained release of pharmaceutical drugs
Autor:
Arijit Bose, Swapnil A. Malekar, Ashish L. Sarode, Geoffrey D. Bothun, Alvin C. Bach, David R. Worthen
Publikováno v:
AAPS PharmSciTech. 16(6)
This work was conducted in order to design, characterize, and evaluate stable liposomes containing the hydrophobic drug raloxifene HCl (RAL) and hydrophilic doxycycline HCl (DOX), two potentially synergistic agents for treating osteoporosis and other
Publikováno v:
Carbohydrate polymers. 112
Overcoming the low oral bioavailability of many drugs due to their poor aqueous solubility is one of the major challenges in the pharmaceutical industry. The production of amorphous solid dispersions (ASDs) of these drugs using hydrophilic polymers m
Publikováno v:
AAPS Advances in the Pharmaceutical Sciences Series ISBN: 9781461484318
The development of bioavailable solid dispersions requires the use of secondary materials for stabilizing the amorphous dispersion while also enhancing dissolution and solubility of the new chemical entity. With the increased use of amorphous dispers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc01f99045d0e372b5c2a391e020382e
https://doi.org/10.1007/978-1-4614-8432-5_4
https://doi.org/10.1007/978-1-4614-8432-5_4
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 86(3)
The influence of polymers on the dissolution, supersaturation, crystallization, and partitioning of poorly water soluble compounds in biphasic media was evaluated. Amorphous solid dispersions (ASDs) containing felodipine (FLD) and itraconazole (ITZ)
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 48(3)
The processing parameters for HME have been evaluated and the impact of solid state intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly water soluble drugs Indomethacin (IND), Itraconazole (ITZ), and Griseofulv