Výsledky vyhledávání - "Ashish Kumar Narayan Nair"

A Versatile Approach for the Site-Specific Modification of Recombinant Antibodies Using a Combination of Enzyme-Mediated Bioconjugation and Click Chemistry

Autor: Karlheinz Peter, Paul S. Donnelly, Guy Y. Krippner, Karen Alt, Stan Poniger, Brett M. Paterson, Katie Ardipradja, Henri Tochon-Danguy, Ashish Kumar Narayan Nair, Schweta Jagdale, Erik Westein, Stacey E Rudd, Xiaowei Wang, Timothy U. Connell, Christoph E. Hagemeyer

Publikováno v: Angewandte Chemie International Edition. 54:7515-7519

A unique two-step modular system for site-specific antibody modification and conjugation is reported. The first step of this approach uses enzymatic bioconjugation with the transpeptidase Sortase A for incorporation of strained cyclooctyne functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38583997836bbf72e702e2336af33b87
https://doi.org/10.1002/anie.201411507

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Enzymatic Single-Chain Antibody Tagging

Autor: Katherine E. Jackson, Karlheinz Peter, H. Pearce, D. von Elverfeldt, Hang T. Ta, Christoph E. Hagemeyer, Ashish Kumar Narayan Nair, Sandeep Prabhu, C. von zur Muhlen, Timo Heidt, Ephraem Leitner, Fu Jia, Xiaowei Wang

Publikováno v: Circulation Research. 109:365-373

Rationale: Antibody-targeted delivery of imaging agents can enhance the sensitivity and accuracy of current imaging techniques. Similarly, homing of effector cells to disease sites increases the efficacy of regenerative cell therapy while reducing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94edf117e91c5f67e4072b8b04b5a5c7
https://doi.org/10.1161/circresaha.111.249375

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Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes

Autor: Anne Y Zhao, Nicholas A. Williamson, Jan Petersen, Roza Nastovska, Sri H. Ramarathinam, Geordie Rudge, Ashish Kumar Narayan Nair, Jamie Rossjohn, Anthony W. Purcell, Hugh H. Reid, Stephanie J Wurzbacher

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 106(8)

Human leukocyte antigen (HLA) class I molecules present a variety of posttranslationally modified epitopes at the cell surface, although the consequences of such presentation remain largely unclear. Phosphorylation plays a critical cellular role, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87cdc4253b8c95ff000bf2b0b0b9186
https://pubmed.ncbi.nlm.nih.gov/19196958

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