Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Ashish K. Pathak"'
Autor:
Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245013 (2021)
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have
Externí odkaz:
https://doaj.org/article/952fb40efdab473d99e7cb134f2a7cbb
Autor:
Mark T. Heise, Thomas E. Morrison, Subramaniam Ananthan, Joseph A. Maddry, Sanjay Sarkar, Jessica L. Smith, Kevin J Rodzinak, Nicole N. Haese, Daniel N. Streblow, Nathaniel J. Moorman, Cassilyn E. Streblow, Ashish K. Pathak, Vibha Pathak, Aaron D Streblow, Lynn Rasmussen, Fahim Ahmad, Corinne E. Augelli-Szafran, S Kaleem Ahmed, Victor R. DeFilippis, Robert Bostwick, Craig N. Kreklywich, Mark J. Suto, Sixue Zhang, Robbie Allen, Alec J. Hirsch, Jaden T Cowan, Babu L. Tekwani, Kiley Bonin, Nichole A. Tower, Wes Sander, Valerie J Smith, Mousheng Wu, John M Gerdes, Clayton R. Morrison, Omar Moukha-Chafiq
Publikováno v:
J Med Chem
A benzo[6]annulene, 4-(tert-butyl)-N-(3-methoxy-5,6,7,8-tetrahydronaphthalen-2-yl) benzamide (1a), was identified as an inhibitor against Chikungunya virus (CHIKV) with antiviral activity EC(90) = 1.45 μM and viral titer reduction (VTR) of 2.5 log a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd9fc90c3516c776e90ca2779eb4634
https://doi.org/10.1021/acs.jmedchem.0c02183
https://doi.org/10.1021/acs.jmedchem.0c02183
Publikováno v:
PLANT ARCHIVES. 21:2049-2053
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d22475206d8425234a48b7e69af48e6
https://doi.org/10.51470/plantarchives.2021.v21.s1.336
https://doi.org/10.51470/plantarchives.2021.v21.s1.336
Publikováno v:
PLANT ARCHIVES. 21:2054-2058
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6776f8b95a4aa989c4af2fba1f0a3a66
https://doi.org/10.51470/plantarchives.2021.v21.s1.337
https://doi.org/10.51470/plantarchives.2021.v21.s1.337
Publikováno v:
3 Biotech
Litchi is a sub-tropical fruit crop with genotypes that bear fruits with variable seed size. Small seed size is a desirable trait in litchi, as it improves consumers’ preference and facilitates fruit processing. Seed specific transcriptome analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45a9b0fbfa1ac4a84212e2eb48bd0b4
https://doi.org/10.1007/s13205-021-03098-8
https://doi.org/10.1007/s13205-021-03098-8
Autor:
Nathaniel J. Moorman, Nikhil Madadi, Daniel N. Streblow, Nicole N. Haese, Robert Bostwick, Mark T. Heise, Wes Sanders, Theresa H Nguyen, Corinne E. Augelli-Szafran, Nichole A Towers, Omar Moukha-Chafiq, Victor R. DeFilippis, Joseph A. Maddry, Sixue Zhang, Ashish K. Pathak, Mark J. Suto, Subramaniam Ananthan, Sharon Taft-Benz, Lynn Rasmussen, Shuklendu D Karyakarte, Michael Denton, Nicholas A May, Kevin J Rodzinak, Aaron D Streblow, Thomas E. Morrison
Publikováno v:
Antimicrob Agents Chemother
Venezuelan equine encephalitis virus (VEEV) is a reemerging alphavirus that can cause encephalitis resulting in severe human morbidity and mortality. Using a high-throughput cell-based screen, we identified a quinolinone compound that protected again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19d1e226b321e833dfc136126ea7547
https://pubmed.ncbi.nlm.nih.gov/34152810
https://pubmed.ncbi.nlm.nih.gov/34152810
Autor:
Atefeh Garzan, Sixue Zhang, Daniel N. Streblow, Nicole N. Haese, Yohanka Martinez-Gzegozewska, Robert Bostwick, Ashish K. Pathak, Corinne E. Augelli-Szafran, Lynn Rasmussen, Mousheng Wu, Mark T. Haise
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245013 (2021)
PLoS ONE
PLoS ONE
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence. No small molecule drugs targeting CHIKV nsP3 have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074b66f4f6416b56fbdf8cff7fa13942
https://doaj.org/article/952fb40efdab473d99e7cb134f2a7cbb
https://doaj.org/article/952fb40efdab473d99e7cb134f2a7cbb
Publikováno v:
ACS combinatorial science. 21(3)
Under the aegis of the Pilot Scale Library Program of the NIH Roadmap Initiative, a new library of propan-1-amine containing aza acyclic nucleosides was designed and prepared, and we now report a diverse set of 157 purine, pyrimidine, and 1,2,4-triaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d800944ea7cc610e079026cea26eff
https://pubmed.ncbi.nlm.nih.gov/30653914
https://pubmed.ncbi.nlm.nih.gov/30653914
Autor:
Victor R. DeFilippis, Theresa H Nguyen, Mark J. Suto, Corinne E. Augelli-Szafran, Sharon Taft-Benz, Kiley Bonin, Lynn Rasmussen, Cassilyn E. Streblow, Daniel N. Streblow, Sanjay Sarkar, Ashish K. Pathak, Nichole A. Tower, Nicole N. Haese, Thomas E. Morrison, Nikhil Madadi, Mark T. Heise, Robert Bostwick
Alphaviruses are arthropod-transmitted members of the Togaviridae family that can cause severe disease in humans, including debilitating arthralgia and severe neurological complications. Currently, there are no approved vaccines or antiviral therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfc77355e550dc8830ebe5adbe512e9
Autor:
Amit Kumar Srivastava, Pradeep K. Singour, Bhupendra K. Goutam, Ashish K. Pathak, Panchanan Gouda, Sunil Kumar
Publikováno v:
Central Nervous System Agents in Medicinal Chemistry. 16:143-151
Background: A quantitative structure-activity relationship (QSAR) study of novel Acetamide derivatives as specific Mono amino oxidase (MAO) A inhibitory agents was performed with 28 compounds to derive QSAR models for better activity and lesser side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216d87ffd240a982b97bec1688ad284a
https://doi.org/10.2174/1871524916666151210143347
https://doi.org/10.2174/1871524916666151210143347