Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ashique, Rafique"'
Autor:
Yi Zhou, Panayiotis E. Stevis, Jing Cao, George Ehrlich, Jennifer Jones, Ashique Rafique, Mark W. Sleeman, William C. Olson, Matthew C. Franklin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Oncostatin M (OSM) is a unique Interleukin 6 (IL-6) family cytokine that plays pivotal roles in numerous biological events by signaling via two types of receptor complexes. While type I OSM receptor complex is formed by glycoprotein 130 (gp1
Externí odkaz:
https://doaj.org/article/26099cedba414bd89105c9d262c4020b
Autor:
Kei Saotome, Drew Dudgeon, Kiersten Colotti, Michael J. Moore, Jennifer Jones, Yi Zhou, Ashique Rafique, George D. Yancopoulos, Andrew J. Murphy, John C. Lin, William C. Olson, Matthew C. Franklin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The recognition of antigenic peptide-MHC (pMHC) molecules by T-cell receptors (TCR) initiates the T-cell mediated immune response. Structural characterization is key for understanding the specificity of TCR-pMHC interactions and informing th
Externí odkaz:
https://doaj.org/article/b9018cbe0b6a4978a8f32fe09d1a6a00
Autor:
Selin Somersan-Karakaya, Kenneth C. Turner, Luz Cortes-Burgos, Jutta Miller, Michael LaCroix-Fralish, Veronika Logovinsky, Yamini Patel, Richard Torres, Samit Ganguly, Aurora Breazna, Michelle DeVeaux, Rafia Bhore, Min Gao, Frank J. Delfino, Ashique Rafique, Jeanette L. Fairhurst, Charleen Hunt, Robert Babb, Ashok Badithe, William T. Poueymirou, Ronald Surowitz, Sylvie Rottey, Andrew J. Murphy, Olivier Harari, Lynn E. Macdonald, Susan D. Croll
Publikováno v:
Neurobiology of Pain, Vol 14, Iss , Pp 100136- (2023)
The artemin-GFRα3 signaling pathway has been implicated in various painful conditions including migraine, cold allodynia, hyperalgesia, inflammatory bone pain, and mouse knees contain GFRα3-immunoreactive nerve endings. We developed high affinity m
Externí odkaz:
https://doaj.org/article/c0682c375e514d369668aca491d09e17
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Jonathan W. Cruz, Ermelinda Damko, Bhavika Modi, Naxin Tu, Karoline Meagher, Vera Voronina, Hans Gartner, George Ehrlich, Ashique Rafique, Robert Babb, Priya Aneja, Terra B. Potocky, Amanda D’ Orvilliers, Alida Coppi, Sook Yen E, Haibo Qiu, Courtney M. Williams, Brandy L. Bennett, Gang Chen, Lynn Macdonald, William Olson, John C. Lin, Neil Stahl, Andrew J. Murphy, Christos A. Kyratsous, Brinda C. Prasad
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Abstract Harnessing complement-mediated cytotoxicity by therapeutic antibodies has been limited because of dependency on size and density of antigen, structural constraints resulting from orientation of antibody binding, and blockade of complement ac
Externí odkaz:
https://doaj.org/article/a1c56187022f4047924380652a772499
Autor:
Senem Aykul, Richard A Corpina, Erich J Goebel, Camille J Cunanan, Alexandra Dimitriou, Hyon Jong Kim, Qian Zhang, Ashique Rafique, Raymond Leidich, Xin Wang, Joyce McClain, Johanna Jimenez, Kalyan C Nannuru, Nyanza J Rothman, John B Lees-Shepard, Erik Martinez-Hackert, Andrew J Murphy, Thomas B Thompson, Aris N Economides, Vincent Idone
Publikováno v:
eLife, Vol 9 (2020)
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unex
Externí odkaz:
https://doaj.org/article/f046d1441e0d4e23a1f1b1baf6223516
Autor:
Adrianna Latuszek, Yashu Liu, Olav Olsen, Randi Foster, Marc Cao, Irena Lovric, Ming Yuan, Nina Liu, Henry Chen, Qian Zhang, Hui Xiao, Carola Springer, George Ehrlich, Vishal Kamat, Ashique Rafique, Ying Hu, Pamela Krueger, Tammy Huang, William Poueymirou, Robert Babb, Michael P Rosconi, Marc W Retter, Gang Chen, Lori Morton, Brian Zambrowicz, Jingtai Cao, Carmelo Romano, William C Olson
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0231892 (2020)
Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but
Externí odkaz:
https://doaj.org/article/050c7eb8e3d948eab37777fb62eda2e6
Autor:
Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscl
Externí odkaz:
https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
Autor:
Markus Mohrs, Gavin Thurston, Ella Ioffe, Andrew Murphy, William C. Olson, Douglas MacDonald, Joel Martin, William Poueymirou, Ashique Rafique, Jerry Pei, Amy Woodruff, Omaira Allbritton, Matt Liu, Seongwon Hong, Terra Potocky, Gabor Halasz, Erica Ullman, Jie Dai, Aynur Hermann, Elena Burova
Supplementary Figure S5 shows expression of human PD-1 and human LAG-3 in PD-1xLAG-3 mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac544c1a0e16bcd786ad36dde232cc
https://doi.org/10.1158/1535-7163.22506958.v1
https://doi.org/10.1158/1535-7163.22506958.v1
Autor:
Gavin Thurston, Andrew Murphy, Israel Lowy, William Olson, Ella Ioffe, Douglas MacDonald, Markus Mohrs, Jon Popke, Joel Kantrowitz, Dimitris Skokos, Tammy Huang, Joel Martin, William Poueymirou, Ashique Rafique, Elena Garnova, Amanda D’Orvilliers, Qi Wu, Amy Woodruff, Omaira Allbritton, Matt Liu, Seongwon Hong, Venus Lai, Terra Potocky, Janelle Waite, Aynur Hermann, Elena Burova
REGN2810 does not induce ADCC or CDC in either unstimulated or CD3/CD28 stimulated Jurkat cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea717341b47e08f24bd0f4dd4ae5f65
https://doi.org/10.1158/1535-7163.22505034.v1
https://doi.org/10.1158/1535-7163.22505034.v1