Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ashima, Bhaskar"'
Autor:
Meetu Agarwal, Ashima Bhaskar, Biplab Singha, Suparba Mukhopadhyay, Isha Pahuja, Archna Singh, Shivam Chaturvedi, Nisheeth Agarwal, Ved Prakash Dwivedi, Vinay Kumar Nandicoori
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract The limitations of TB treatment are the long duration and immune-dampening effects of anti-tuberculosis therapy. The Cell wall plays a crucial role in survival and virulence; hence, enzymes involved in its biosynthesis are good therapeutic t
Externí odkaz:
https://doaj.org/article/578dbbd1d59c4fc6ba88486f2c23318f
Autor:
Isha Pahuja, Antara Ghoshal, Ahmed Abdallah Okieh, Akanksha Verma, Kriti Negi, Meetu Agarwal, Nidhi Subhash Chandra, Saurabh Kumar Sharma, Ashima Bhaskar, Ved Prakash Dwivedi
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 7 (2024)
ABSTRACT The host immune responses play a pivotal role in the establishment of long-term memory responses, which effectively aids in infection clearance. However, the prevailing anti-tuberculosis therapy, while aiming to combat tuberculosis (TB), als
Externí odkaz:
https://doaj.org/article/6099b1271ad74eb9bfa8b12dd780f110
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Mycobacterium tuberculosis (M.tb) effectively manipulates the host processes to establish the deadly respiratory disease, Tuberculosis (TB). M.tb has developed key mechanisms to disrupt the host cell health to combat immune responses and replicate ef
Externí odkaz:
https://doaj.org/article/30c3c1a13d9147c8ae0f4866abdecfff
Autor:
Isha Pahuja, Akanksha Verma, Antara Ghoshal, Suparba Mukhopadhyay, Anjna Kumari, Aishwarya Shaji, Shivam Chaturvedi, Ved Prakash Dwivedi, Ashima Bhaskar
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT Tuberculosis (TB) still tops the list of global health burdens even after COVID-19. However, it will sooner transcend the current pandemic due to the prevailing risk of reactivation of latent TB in immunocompromised individuals. The indiscri
Externí odkaz:
https://doaj.org/article/675b2b421b604bc2a35f8590c8d66e10
Autor:
Ashima Bhaskar, Isha Pahuja, Kriti Negi, Akanksha Verma, Antara Ghoshal, Babu Mathew, Gaurav Tripathi, Jaswinder Singh Maras, Shivam Chaturvedi, Ved Prakash Dwivedi
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106644- (2023)
Summary: Bacille Calmette-Guerin (BCG) generates limited long-lasting adaptive memory responses leading to short-lived protection against adult pulmonary tuberculosis (TB). Here, we show that host sirtuin 2 (SIRT2) inhibition by AGK2 significantly en
Externí odkaz:
https://doaj.org/article/b1a568ab7b094d5db897ff8de9f22986
Autor:
Isha Pahuja, Kriti Negi, Anjna Kumari, Meetu Agarwal, Suparba Mukhopadhyay, Babu Mathew, Shivam Chaturvedi, Jaswinder Singh Maras, Ashima Bhaskar, Ved Prakash Dwivedi
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011165 (2023)
Stimulation of naïve T cells during primary infection or vaccination drives the differentiation and expansion of effector and memory T cells that mediate immediate and long-term protection. Despite self-reliant rescue from infection, BCG vaccination
Externí odkaz:
https://doaj.org/article/967590c0dc944bd3aa614868c04c107d
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Mycobacterium tuberculosis (M.tb) is an intracellular pathogen that predominantly affects the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and TLR4- mediated signaling pathways leads to lysosomal degradation o
Externí odkaz:
https://doaj.org/article/b9344ba412a94423afc21d9a1241efb7
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The pursuit to improve the TB control program comprising one approved vaccine, M. bovis Bacille Calmette-Guerin (BCG) has directed researchers to explore progressive approaches to halt the eternal TB pandemic. Mycobacterium tuberculosis (M.tb) was fi
Externí odkaz:
https://doaj.org/article/df5246c0de8b40ea8513b20a7c46835c
Autor:
Dhiraj Kumar Singh, Sultan Tousif, Ashima Bhaskar, Annu Devi, Kriti Negi, Barnani Moitra, Anand Ranganathan, Ved Prakash Dwivedi, Gobardhan Das
Publikováno v:
PLoS Pathogens, Vol 17, Iss 8, p e1009805 (2021)
Tuberculosis (TB) remains a major health problem throughout the world with one third of the population latently infected and ~1.74 million deaths annually. Current therapy consists of multiple antibiotics and a lengthy treatment regimen, which is ass
Externí odkaz:
https://doaj.org/article/93fb6bb20ab94443ba71835315feeff6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Tuberculosis (TB) is an infectious disease caused by an obligate intracellular pathogen, Mycobacterium tuberculosis (M.tb) and is responsible for the maximum number of deaths due to a single infectious agent. Current therapy for TB, Directly Observed
Externí odkaz:
https://doaj.org/article/b5b06902870643d8942d437cb9d3d355