Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Ashim Paul"'
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 11, Pp 2215-2216 (2021)
Externí odkaz:
https://doaj.org/article/c8acd4efbee849ebbd4b5247c493092d
Autor:
Rajat Subhra Giri, Srinivasa Rao Manne, Gobinda Dolai, Ashim Paul, Tapasi Kalita, Bhubaneswar Mandal
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 6586-6597 (2017)
Externí odkaz:
https://doaj.org/article/3ecbf2810de445ad9eeac3aa68529823
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
A current challenge faced by researchers is the lack of disease-modifying therapeutics for amyloid formation that is associated with several human diseases. Although the monomeric proteins or peptides involved in various amyloidogenic diseases do not
Externí odkaz:
https://doaj.org/article/2f4144b318db4b478a875038e9128a84
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
The aggregation of the amyloidogenic protein α-synuclein (α-Syn) into toxic oligomers and mature fibrils is the major pathological hallmark of Parkinson's disease (PD). Small molecules that inhibit α-Syn aggregation thus may be useful therapeutics
Externí odkaz:
https://doaj.org/article/3ffafac4eb414275b575c4fff0f4179f
Autor:
Guru KrishnaKumar Viswanathan, Satabdee Mohapatra, Ashim Paul, Elad Arad, Raz Jelinek, Ehud Gazit, Daniel Segal
Publikováno v:
Molecules, Vol 23, Iss 12, p 3279 (2018)
PAP248⁻286, a 39 amino acid peptide fragment, derived from the prostatic acid phosphatase secreted in human semen, forms amyloid fibrils and facilitates the attachment of retroviruses to host cells that results in the enhancement of viral infection
Externí odkaz:
https://doaj.org/article/8e786a2bcf174a50839dd720eaceeb04
Autor:
Sourav Kumar, D. Sarkar, Ashim Paul, Anirban Bhunia, Sujan Kalita, Amal Chandra Mondal, Sourav Kalita, Bhubaneswar Mandal, Anupam Bandyopadhyay
Publikováno v:
Chemical Science. 12:2853-2862
Synthetic antibodies hold great promise in combating diseases, diagnosis, and a wide range of biomedical applications. However, designing a therapeutically amenable, synthetic antibody that can arrest the aggregation of amyloid-β (Aβ) remains chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dcee44f86074d6c4caeef4a0bde21c5
https://doi.org/10.1039/d0sc04379f
https://doi.org/10.1039/d0sc04379f
Publikováno v:
RSC Chemical Biology
Amylin or hIAPP, together with insulin, plays a significant role in glucose metabolism. However, it undergoes β-sheet rich amyloid formation associated with pancreatic β-cell dysfunction leading to type-2 diabetes (T2D). Recent studies suggest that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ceab70a5b79b580098b7cb98d4aba0e
http://europepmc.org/articles/PMC8341151
http://europepmc.org/articles/PMC8341151
Autor:
Guru KrishnaKumar Viswanathan, Ashim Paul, Ehud Gazit, Daniel L. Segal, Esraa Haj, Malak Abu-Hussien
Publikováno v:
International Journal of Biological Macromolecules. 157:424-433
The eye lens is rich in proteins called crystallins, whose native conformation is crucial for preserving its transparency. With aging, crystallins may be exposed to environmental changes, which could lead to their aggregation and eventually to catara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9ec96670c5a56fe8169f839ef57554
https://doi.org/10.1016/j.ijbiomac.2020.04.079
https://doi.org/10.1016/j.ijbiomac.2020.04.079
Publikováno v:
Chemical Science
Alzheimer's disease (AD) is the most common form of dementia affecting the elderly population worldwide. Despite enormous efforts and considerable advancement in research, no therapeutic agents have come to light to date. However, many peptide-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb2685930c653e51b5da2934fcdabfaa
https://doi.org/10.1039/c9sc06076f
https://doi.org/10.1039/c9sc06076f
Autor:
Ashim Paul, Santu Bera, Petr Král, Phil Mickel, Linda J. W. Shimon, Daniel L. Segal, Zohar A. Arnon, Priyadarshi Chakraborty, Ehud Gazit
Publikováno v:
Angewandte Chemie. 134
Despite the fundamental clinical importance of amyloid fibril formation, its mechanism is still enigmatic. Crystallography of minimal amyloid models was a milestone in the understanding of the architecture and biological activities of amyloid fibers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b276fa1413feb13e0afb708cd717662
https://doi.org/10.1002/ange.202113845
https://doi.org/10.1002/ange.202113845