Production of a high purity, C-tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions

Autor: Mukhopadhyay, E, Brod, F, Angell-Manning, P, Green, N, Tarrant, RD, Detmers, FJ, Bolam, EJ, Baleanu, IN, Hobson, M, Whale, G, Morris, SJ, Ashfield, R, Gilbert, SC, Jin, J, Draper, SJ, Moyle, SP, Berrie, EL, Hill, AVS

Virus-like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the method used for the production of R21, a VLP-based anti-sporozoite malaria vaccine, under cur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4199bb484100c366f49079cc7a5165
https://ora.ox.ac.uk/objects/uuid:5aa5d350-6828-4770-b273-99e5bf9e0b3b

24 ARQ-234: a high affinity CD200-Fc fusion protein for the treatment of atopic dermatitis

Autor: Ashfield, R., Sheridan, J., Heal, J., Berk, D., Burnett, P., Blackbourn, D., Huxley, P.

Publikováno v: In Journal of Investigative Dermatology November 2023 143(11) Supplement:S336-S336

Efficacy of the novel Plasmodium falciparum blood-stage vaccine RH5.1/AS01B in a phase I/IIA clinical trial

Autor: Minassian, A, Silk, S, Poulton, I, Mitton, C, Payne, R, Rawlinson, T, Barrett, J, Baker, M, Ramon, R, Lopez, F, Edwards, N, Ellis, K, Nielsen, C, Quinkert, D, Barfod, L, Miura, K, Diouf, A, Folegatti, P, Silman, D, Datoo, M, Smith, R, Berrie, E, Morelle, D, Lievens, M, Noe, A, Diggs, C, Soisson, L, Ashfield, R, Long, C, Nugent, F, Lawrie, A, Draper, S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::96c5fea7a0e83b87ecfc3085b7c1ec88
https://doi.org/10.4269/ajtmh.abstract2018

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions

Autor: Payne, RO, Silk, SE, Elias, SC, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, NJ, Poulton, ID, Griffiths, OJ, Edwards, NJ, Jin, J, Labbé, GM, Alanine, DG, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A.S., Nielsen, C.M., Bardelli, M., Partey, F.D., Ofori, M.F., Barfod, L., Wambua, J., Murungi, L.M., Osier, F.H., Biswas, S., McCarthy, J.S., Minassian, A.M., Ashfield, R., Viebig, N.K., Nugent, F.L., Douglas, A.D., Vekemans, J., Wright, G.J., Faust, S.N., Hill, A.V., Long, C.A., Lawrie, A.M., Draper, S.J.

Publikováno v: Payne, R O, Silk, S E, Elias, S C, Miura, K, Diouf, A, Galaway, F, de Graaf, H, Brendish, N J, Poulton, I D, Griffiths, O J, Edwards, N J, Jin, J, Labbé, G M, Alanine, D G, Siani, L, Di Marco, S, Roberts, R, Green, N, Berrie, E, Ishizuka, A S, Nielsen, C M, Bardelli, M, Partey, F D, Ofori, M F, Barfod, L, Wambua, J, Murungi, L M, Osier, F H, Biswas, S, McCarthy, J S, Minassian, A M, Ashfield, R, Viebig, N K, Nugent, F L, Douglas, A D, Vekemans, J, Wright, G J, Faust, S N, Hill, A V, Long, C A, Lawrie, A M & Draper, S J 2017, ' Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions ', JCI insight, vol. 2, no. 21, e96381 . https://doi.org/10.1172/jci.insight.96381

The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) has emerged as the most promisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6bf35a8938147f9a47ac6504de737b6a
http://ora.ox.ac.uk/objects/uuid: