Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Ashfaq Ur Rehman"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6201 (2024)
SHP2, a pivotal component downstream of both receptor and non-receptor tyrosine kinases, has been underscored in the progression of various human cancers and neurodevelopmental disorders. Allosteric inhibitors have been proposed to regulate its autoi
Externí odkaz:
https://doaj.org/article/cc9c4386ca904787bdd28d09c2f8f85a
Autor:
Abdus Samad, Amar Ajmal, Arif Mahmood, Beenish Khurshid, Ping Li, Syed Mansoor Jan, Ashfaq Ur Rehman, Pei He, Ashraf N. Abdalla, Muhammad Umair, Junjian Hu, Abdul Wadood
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
The new coronavirus SARS-COV-2, which emerged in late 2019 from Wuhan city of China was regarded as causing agent of the COVID-19 pandemic. The primary protease which is also known by various synonymous i.e., main protease, 3-Chymotrypsin-like protea
Externí odkaz:
https://doaj.org/article/9586b94f5df34b2f96283270630ddbe7
Autor:
Tayyab Saleem, Syed Babar Jamal, Badr Alzahrani, Amina Basheer, Sumra Wajid Abbasi, Mahwish Ali, Ashfaq Ur Rehman, Muhammad Faheem
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Naegleria fowleri (N. fowleri) is a free-living thermophilic amoeba of fresh water and soil. The amoeba primarily feeds on bacteria but can be transmitted to humans upon contact with freshwater sources. Furthermore, this brain-eating amoeba enters th
Externí odkaz:
https://doaj.org/article/e4a8d53885c644d1978dde7a06b26dc7
Autor:
Abdul Wadood, Azam Shareef, Ashfaq Ur Rehman, Shabbir Muhammad, Beenish Khurshid, Raham Sher Khan, Sulaiman Shams, Sahib Gul Afridi
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 397-408 (2021)
Externí odkaz:
https://doaj.org/article/21282b97c22b4710933e5f9c7da17820
Autor:
Irrum Mushtaq, Zareen Akhter, Muhammad Farooq, Farukh Jabeen, Ashfaq Ur Rehman, Sadia Rehman, Sidra Ayub, Bushra Mirza, Muhammad Siddiq, Farasat Zaman
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The drug delivery system (DDS) often causes toxicity, triggering undesired cellular injuries. Thus, developing supramolecules used as DDS with tunable self-assembly and nontoxic behavior is highly desired. To address this, we aimed to develo
Externí odkaz:
https://doaj.org/article/8e81c64057bc4c4bafbd8e34675aa84b
Autor:
Rifhat Sultana, Obaid-ur-Rahman Abid, Nighat Sultana, M. Fakhar-e-Alam, Muhammad Hussnain Siddique, M. Atif, Mohsin Nawaz, Abdul Wadood, Ashfaq Ur Rehman, W.A. Farooq, Sulman Shafeeq, Muhammad Afzal
Publikováno v:
Journal of Saudi Chemical Society, Vol 26, Iss 6, Pp 101565- (2022)
Enzyme inhibitors are vital aspects for studying enzymes and are employed as drugs to treat certain disorders, thus implying pivotal role in drug discovery. In the current study, a series of triazole compounds 4(a-o) were synthesised to explore their
Externí odkaz:
https://doaj.org/article/32700315995f41918c0e6bc01b83ffbf
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The trans-membrane proteins of the B7 family programmed cell death ligand-1 (PD-L1) and programmed death-1 (PD-1) play important roles in inhibiting immune responses and enhancing self-tolerance via T-cell modulation. Several therapeutic antibodies a
Externí odkaz:
https://doaj.org/article/b2cb26198c994ce2a3e7fd52869976e6
Autor:
Arshad Mehmood, Jiayi Li, Ashfaq Ur Rehman, Rovina Kobun, Inam U Llah, Imran Khan, Fayez Althobaiti, Sarah Albogami, Muhammad Usman, Fahad Alharthi, Mohamed Mohamed Soliman, Sanabil Yaqoob, Kanza Aziz Awan, Liang Zhao, Lei Zhao
Publikováno v:
Frontiers in Nutrition, Vol 9 (2022)
This project was designed to explore the xanthine oxidase (XO) inhibitory mechanism of eight structurally diverse phenolic compounds [quercetin: C1, quercetin-3-rhamnoside: C2, 4, 5-O-dicaffeoylquinic acid: C3, 3, 5-O-dicaffeoylquinic acid: C4, 3, 4-
Externí odkaz:
https://doaj.org/article/02cc0097530f4f46bd4c08b5bcee2f36
Autor:
Shaoyong Lu, Xinheng He, Zhao Yang, Zongtao Chai, Shuhua Zhou, Junyan Wang, Ashfaq Ur Rehman, Duan Ni, Jun Pu, Jinpeng Sun, Jian Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
G protein-coupled receptors (GPCRs) are a critical target in modern drug development across a wide range of indications. Here the authors provide a comprehensive characterization of a typical GPCR, the angiotensin II (AngII) type 1 receptor (AT1R), a
Externí odkaz:
https://doaj.org/article/ac9008e70a2947a995418dd644c36965
Autor:
Fayaz Ali, Shahbaz Shamim, Mehreen Lateef, Khalid Mohammed Khan, Muhammad Taha, Uzma Salar, Abdul Wadood, Ashfaq Ur Rehman, Noor Ul Ain Nawaz, Shahnaz Perveen
Publikováno v:
ACS Omega, Vol 6, Iss 24, Pp 15794-15803 (2021)
Externí odkaz:
https://doaj.org/article/9532eedd41a04444994d1262fbd11469