Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Asher Maroof"'
Autor:
Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTRozanolixizumab is a humanized anti-neonatal Fc receptor (FcRn) monoclonal antibody (mAb) of the immunoglobulin G4 (IgG4) sub-class, currently in clinical development for the treatment of IgG autoantibody-driven diseases. This format is frequ
Externí odkaz:
https://doaj.org/article/f74b0a47f067425f9e3ed7abc893041a
Autor:
Emma Davé, Oliver Durrant, Neha Dhami, Joanne Compson, Janice Broadbridge, Sophie Archer, Asher Maroof, Kevin Whale, Karelle Menochet, Pierre Bonnaillie, Emily Barry, Gavin Wild, Claude Peerboom, Pallavi Bhatta, Mark Ellis, Matthew Hinchliffe, David P. Humphreys, Sam P. Heywood
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTTrYbe® is an Fc-free therapeutic antibody format, capable of engaging up to three targets simultaneously, with long in vivo half-life conferred by albumin binding. This format is shown by small-angle X-ray scattering to be conformationally f
Externí odkaz:
https://doaj.org/article/da5a5f25917d459295f40b2ca83010e7
Autor:
Suzanne Cole, Janine Murray, Catherine Simpson, Remi Okoye, Kerry Tyson, Meryn Griffiths, Dominique Baeten, Stevan Shaw, Asher Maroof
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
IL-23 is considered a critical regulator of IL-17 in Th17 cells; however, its requirement for inducing IL-17 production in other human immune subsets remains incompletely understood. Mucosal associated invariant T (MAIT) cells uniformly express retin
Externí odkaz:
https://doaj.org/article/9977591d4c7042d0b21fe34563635126
Autor:
Dominique Baeten, Stevan Shaw, Mittal Shah, Asher Maroof, Panos Gikas, Gayatri Mittal, Richard Keen, Scott J Roberts
Publikováno v:
RMD Open, Vol 6, Iss 2 (2020)
Objectives Interleukin (IL)-17 signalling has been shown to be a key regulator of disease in ankylosing spondylitis (AS) with several IL-17 blockers currently clinically approved. Despite this, the role of IL-17 in bone pathology is poorly understood
Externí odkaz:
https://doaj.org/article/3c4af04ceda542ef8d125c3a054f81d0
Autor:
Ralph Adams, Asher Maroof, Terry Baker, Alastair D. G. Lawson, Ruth Oliver, Ross Paveley, Steve Rapecki, Stevan Shaw, Pavan Vajjah, Shauna West, Meryn Griffiths
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Interleukin (IL)-17A is a key driver of inflammation and the principal target of anti-IL-17 therapeutic monoclonal antibodies. IL-17A, and its structurally similar family member IL-17F, have been shown to be functionally dysregulated in certain human
Externí odkaz:
https://doaj.org/article/b1dbe735c4a147d884a03b1106dffb94
Autor:
Alan J. Hayes, Sanket Rane, Hannah E. Scales, Gavin R. Meehan, Robert A. Benson, Asher Maroof, Juliane Schroeder, Michio Tomura, Neil Gozzard, Andrew J. Yates, Paul Garside, James M. Brewer
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Initiation of adaptive immunity involves distinct migratory cell populations coming together in a highly dynamic and spatially organized process. However, we lack a detailed spatiotemporal map of these events due to our inability to track the fate of
Externí odkaz:
https://doaj.org/article/990e096a122f42f8ab6e7b00751d7cba
Autor:
John W J Moore, Lynette Beattie, Mohamed Osman, Benjamin M J Owens, Najmeeyah Brown, Jane E Dalton, Asher Maroof, Paul M Kaye
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163604 (2016)
Recent thymic emigrants (RTEs) represent a source of antigen-naïve T cells that enter the periphery throughout life. However, whether RTEs contribute to the control of chronic parasitic infection and how their potential might be harnessed by therape
Externí odkaz:
https://doaj.org/article/a8c953ddabaf4a779f8c736ee8ed4224
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003875 (2014)
Influenza disease is a global health issue that causes significant morbidity and mortality through seasonal epidemics. Currently, inactivated influenza virus vaccines given intramuscularly or live attenuated influenza virus vaccines administered intr
Externí odkaz:
https://doaj.org/article/3d5f6fdb3b4047659ce3c2f9a0f85daf
Autor:
Benjamin M J Owens, Lynette Beattie, John W J Moore, Najmeeyah Brown, Jason L Mann, Jane E Dalton, Asher Maroof, Paul M Kaye
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002827 (2012)
IL-10 is a critical regulatory cytokine involved in the pathogenesis of visceral leishmaniasis caused by Leishmania donovani and clinical and experimental data indicate that disease progression is associated with expanded numbers of CD4⁺ IFNγ⁺ T
Externí odkaz:
https://doaj.org/article/bc8b9070bec749369396fafb1a7e5ccc
Autor:
John W J Moore, Lynette Beattie, Jane E Dalton, Benjamin M J Owens, Asher Maroof, Mark C Coles, Paul M Kaye
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34143 (2012)
Hepatic resistance to Leishmania donovani infection in mice is associated with the development of granulomas, in which a variety of lymphoid and non-lymphoid populations accumulate. Although previous studies have identified B cells in hepatic granulo
Externí odkaz:
https://doaj.org/article/d9c5383997ad43b89877953a75155055