Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Asher, Williams"'
Autor:
Abinaya Badri, Asher Williams, Adeola Awofiranye, Payel Datta, Ke Xia, Wenqin He, Keith Fraser, Jonathan S. Dordick, Robert J. Linhardt, Mattheos A. G. Koffas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Chondroitin sulfate (CS) is a type of sulfated glycosaminoglycan that is manufactured by extraction from animal tissues for the treatment of osteoarthritis and in drug delivery applications. Here, the authors report the development of single microbia
Externí odkaz:
https://doaj.org/article/2577cbcebedc48b7b753dd7ad282e97c
Autor:
Asher Williams, Kamil S. Gedeon, Deepika Vaidyanathan, Yanlei Yu, Cynthia H. Collins, Jonathan S. Dordick, Robert J. Linhardt, Mattheos A. G. Koffas
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-13 (2019)
Abstract Background Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important
Externí odkaz:
https://doaj.org/article/153766fdafe74e05b7ab3447aaa4e4a6
Autor:
Katherine F. Warfel, Asher Williams, Derek A. Wong, Sarah E. Sobol, Primit Desai, Jie Li, Yung-Fu Chang, Matthew P. DeLisa, Ashty S. Karim, Michael C. Jewett
Cell-free protein synthesis systems that can be lyophilized for long-term, nonrefrigerated storage and transportation have the potential to enable decentralized biomanufacturing. However, increased thermostability and decreased reaction cost are nece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb1e831a2fe9531353748df7381156e
https://doi.org/10.1101/2022.08.10.503507
https://doi.org/10.1101/2022.08.10.503507
Autor:
Cynthia H. Collins, Deepika Vaidyanathan, Yanlei Yu, Jonathan S. Dordick, Asher Williams, Robert J. Linhardt, Mattheos A. G. Koffas, Kamil S. Gedeon
Publikováno v:
Microbial Cell Factories, Vol 18, Iss 1, Pp 1-13 (2019)
Microbial Cell Factories
Microbial Cell Factories
Background Heparosan is the unsulfated precursor of heparin and heparan sulfate and its synthesis is typically the first step in the production of bioengineered heparin. In addition to its utility as the starting material for this important anticoagu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::838eeb77955835a173873225283ae644
http://link.springer.com/article/10.1186/s12934-019-1187-9
http://link.springer.com/article/10.1186/s12934-019-1187-9
Autor:
So Young Kim, Joydip Kundu, Asher Williams, Anastasia S. Yandulskaya, James R. Monaghan, Rebecca L. Carrier, Robert J. Linhardt
Publikováno v:
Glycoconj J
Retinal degenerative diseases, such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), are major causes of blindness worldwide. Humans cannot regenerate retina, however, axolotl (Ambystoma mexicanum), a laboratory-bred salamande
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d47a9aad742a625192c77297fb86dc1
https://doi.org/10.1007/s10719-019-09863-5
https://doi.org/10.1007/s10719-019-09863-5
Autor:
Ke Xia, Keith Fraser, Asher Williams, Payel Datta, Jonathan S. Dordick, Abinaya Badri, Adeola Awofiranye, Wenqin He, Mattheos A. G. Koffas, Robert J. Linhardt
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Sulfated glycosaminoglycans (GAGs) are a class of important biologics that are currently manufactured by extraction from animal tissues. Although such methods are unsustainable and prone to contamination, animal-free production methods have not emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17ccc71a475f043b3edbabe060f7636
https://doi.org/10.1038/s41467-021-21692-5
https://doi.org/10.1038/s41467-021-21692-5
Autor:
Mattheos A. G. Koffas, Asher Williams, Robert J. Linhardt, Jose Cibelli, Cinzia Stigliano, Yubing Xie, Zachary T. Olmsted, Janet L. Paluh, Philip J. Horner, Fuming Zhang, Abinaya Badri
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Cell therapy for the injured spinal cord will rely on combined advances in human stem cell technologies and delivery strategies. Here we encapsulate homotypic spinal cord neural stem cells (scNSCs) in an alginate-based neural ribbon delivery platform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f37471ff1a6dcb7da5026ba042c23dc
https://doi.org/10.1038/s41598-020-69274-7
https://doi.org/10.1038/s41598-020-69274-7
Autor:
Mattheos A. G. Koffas, Pankaj Karande, Asher Williams, Shikha Nangia, Robert J. Linhardt, Flaviyan Jerome Irudayanathan, Divya G. Shastry
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
The alpha-2,8-linked form of the polysaccharide polysialic acid (PSA) has widespread implications in physiological and pathological processes, ranging from neurological development to disease progression. Though the high electronegativity and exclude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43e9be76e304e236f9d6f0e2448da66
https://doi.org/10.1038/s41598-020-64088-z
https://doi.org/10.1038/s41598-020-64088-z
Publikováno v:
Current Opinion in Biotechnology. 53:85-92
Animal-extraction, despite its limitations, continues to monopolize the fast-growing glycosaminoglycan (GAG) industry. The past few years have seen an increased interest in the development of alternative GAG production methods. Chemical and chemo-enz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc758a0f2c2d68ab1811d8c07f0d127
https://doi.org/10.1016/j.copbio.2017.12.018
https://doi.org/10.1016/j.copbio.2017.12.018
Publikováno v:
Emerging Topics in Life Sciences. 2:337-348
With rising concerns about sustainable practices, environmental complications, and declining resources, metabolic engineers are transforming microorganisms into cellular factories for producing capsular polysaccharides (CPSs). This review provides an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c079e30925b938ee75536adcd62bace7
https://doi.org/10.1042/etls20180003
https://doi.org/10.1042/etls20180003