OP02. NOVEL DNA METHYLATION LANDSCAPE OF METASTATIC COLORECTAL CANCER REVEALS SIGNIFICANT EPIGENETIC REGULATION OF DISEASEASSOCIATED ENHANCER REGIONS

Autor: Cosgrove, Donna, Whitton, L, Donohoe, G, Morris, DW, Das, Sudipto, Moran, B, Smeets, D, Kel, A, George, S, Van Brussel, T, Peutman, G, Klinger, R, Fender, B, Connor, K, Ebert, M, Gaiser, T, Prehn, JHM, Bacon, O, Kay, E, Hennessy, B, Murphy, V, Byrne, A, Gallagher, WM, Lambrechts, D, O’Connor, D, Murphy, Therese M, Crawford, B, Craig, Z, Mansell, G, White, I, Smith, A, Spaull, S, Imm, J, Hannon, E, Wood, A, Yaghootkar, H, Ji, Y, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Mullins, N, Lewis, CM, Mill, J, Shortall, Ciara, Palfi, A, Chadderton, N, Kenna, PF, Carrigan, M, Boomkamp, S, Shen, S, Hardcastle, AJ, Farrar, GJ, Walsh, Naomi, Nelson, S, Zhang, H, Stolzenberg-Solomon, R, Patrick Byrne, Ross, van Rheenen, W, van den Berg, LH, Veldink, JH, McLaughlin, RL, Cassidy, Lara, Bradley, D, Gunne, Emer, Ward, A, Treacy, E, Lambert, D, Lynch, SA, Kostocenko, Marija, Lang, N, Clark, T, Barton, DE, McVeigh, Terri, Kelly, LJ, Whitmore, E, Mullaney, B, Savage, Sarah, Rakovac-Tisdall, A, Rasheed, E, Mac Namara, B, Keogh, E, O’Connor, P, Durkan, M, Maher, V, Griffin, D, MacAdam, B, Vaughan, C, Ryan, M, Heggarty, S, Hart, P, Crowley, VEF, Mullaney, Brendan, McQuaid, S, O’Brien, C, McDevitt, T, Brosnan, K, Logan, Peter, Byrne, C, Scott, J, Dabir, T, Amenyah, Sophia.D, McMahon, A, Ward, M, Deane, J, McNulty, H, Hughes, CF, Strain, JJ, Horigan, G, Purvis, J, Walsh, CP, Lees-Murdock, DJ, Anderson, Kerry, Cañadas-Garre, M, Maxwell, AP, McKnight, AJ, Angel, Zoe, McKenna, DJ, Ariano, Bruno, Mattiangeli, V, Cassidy, LM, McLaughlin, TR, Power, RK, Stock, JT, Mercieca-Spiteri, B, Stoddart, S, Malone, C, Bradley, DG, Atkinson, Sarah D, Campbell, N, Windrum, L, Hassett, P, Bjourson, AJ, Breslin, Emily, Martiniano, R, Silva, AM, Campbell, Ciaran, McCormack, M, Stapleton, C, the EpiPGX Consortium CP Doherty, Delanty, N, Cavalleri, GL, Cooke, Niall, Nakagome, S, D’Cruz, Leon.G, McEleney, K, Tan, K.B.C, Cobice, D, Dobbins, S, Tahanver, A, McLaughlin, C, Conway, C, Small, D, Connolly, C, Gardiner, P, Gibson, D, Flynn, Mairead, Gill, M, Corvin, A, Morris, D, Morrison, CG, Gilbert, Edmund, O’Reilly, S, Merrigan, M, McGettingan, D, Vitart, V, Joshi, PK, Clark, DW, Campbell, H, Hayward, C, Ring, S, Golding, J, Timpson, N, Navarro, P, Kerr, SM, Amador, C, Campbell, A, Haley, CS, Porteous, DJ, Wilson, JF, McNicholas, Áine, Cosgrove, D, Mothersill, DO, Holleran, L, Holland, J, Dauvermann, M, Salter-Townshend, Michael, Myers, SR, Stapleton, Caragh P, On behalf of the UK and Ireland Renal Transplant Consortium, Conlon, PJ, Villikudathil, Angelina T, McGuigan, D, English, A, C, Kelly, McClean, P, Bjourson, T, Shukla, P, Walsh, Darren J, Parle-McDermott, A, Whitton, Laura, Pardinas, A, Walters, J, Yesmambetov, Adlet, Kenna, P, O’Connor, D P, Zang, Jinnan, Simpson, DA, McKay, GJ, Crowley, Vivion, Walsh, E, Abdelfadil, S, Savage, S, MacNamara, B, McKiernan, S, Pazsderska, A, Murphy, R, McCarroll, K, D’Cruz, Leon G, Husain, SA, Yousef, Z, Edkins, S, Ashelford, K, Lai, FA, Duff, Marie, Cody, N, Clabby, C, McVeigh, TP, Green, AJ, Hengeveld, Jennifer, Doherty, MA, Dupuis, L, Vajda, A, Heverin, M, Hardiman, O, Lang, Niamh, O’Byrne, JJ, Kelly, RM, McKenna, Caoimhe, Morrison, P, Lakhanpaul, M, Saxena, N, Dabir, TA, Jones, J, Smith, G, Morrison, PJ, Znaczko, A, Hurrell, D, Donnelly, D, Al Shehhii, M, Jones, E. A., Murray, A, Wedderburn, S, Porteous, M, McVeigh, Úna M, Miller, N, Kerin, MJ, Ghrálaigh, Fiana Ní, Kenny, E, Gallagher, L, Lopez, LM, O’Byrne, James J, Byrne, N, Tapiea, D, Abidin, Z, Pastores, GM, Treacy, EP, Sasaki, Erina, McVeigh, T, O’Hici, B, O’Connell, S, Betts, D, McArdle, L, Hegarty, A, Gill, H, Flanagan, O, McMahon, C, Bradley, L, Scott, Janice, Martin, R, Logan, P, Ward, Alana, Giffney, C, Peyton, C, Turner, J, White, N, Znaczko, Anna, Benson, Katherine A, Kennedy, C, Murray, S, Conlon, P, Dwane, Lisa, Das, S, O’Connor, A E, Mulrane, L, Dirac, A M, Mooney, B, Jirstrom, K, Crown, J P, Bernards, R, Gallagher, W M, Ní Chonghaile, T

Publikováno v: The Ulster Medical Journal

Myocyte enhancer factor 2 C (MEF2C) is a transcription factor that plays a central role regulating cell differentiation, proliferation, survival and apoptosis. MEF2C has been implicated in each of the most recent GWAS of cognitive ability (CA) and ed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::696620cc9e9e6755a0ff119845fdcc13
http://europepmc.org/articles/PMC6342039

Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.

Autor: Lewis T; Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, UK., Corcoran DB; School of Cancer and Pharmaceutical Science, King College London, UK., Thurston DE; School of Cancer and Pharmaceutical Science, King College London, UK., Giles PJ; Cardiff University School of Medicine, Heath Park, Cardiff, UK., Ashelford K; Cardiff University School of Medicine, Heath Park, Cardiff, UK., Walsby EJ; Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, UK., Fegan CD; Division of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, UK., Pepper AGS; Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Miraz Rahman K; School of Cancer and Pharmaceutical Science, King College London, UK., Pepper C; Brighton and Sussex Medical School, University of Sussex, Brighton, UK.

Publikováno v: Haematologica [Haematologica] 2021 Apr 01; Vol. 106 (4), pp. 958-967. Date of Electronic Publication: 2021 Apr 01.

Proof of Concept for Genome Profiling of the Neurofibroma/Sarcoma Sequence in Neurofibromatosis Type 1.

Autor: Cannizzaro, Ilenia Rita¹ (AUTHOR), Treccani, Mirko^1,2 (AUTHOR), Taiani, Antonietta¹ (AUTHOR), Ambrosini, Enrico³ (AUTHOR), Busciglio, Sabrina¹ (AUTHOR), Cesarini, Sofia¹ (AUTHOR), Luberto, Anita¹ (AUTHOR), De Sensi, Erika¹ (AUTHOR), Moschella, Barbara¹ (AUTHOR), Gismondi, Pierpacifico⁴ (AUTHOR), Azzoni, Cinzia⁵ (AUTHOR), Bottarelli, Lorena⁵ (AUTHOR), Giordano, Giovanna⁵ (AUTHOR), Corradi, Domenico⁵ (AUTHOR), Silini, Enrico Maria⁵ (AUTHOR), Zanatta, Valentina⁶ (AUTHOR), Cennamo, Federica⁷ (AUTHOR), Bertolini, Patrizia⁷ (AUTHOR), Caggiati, Patrizia³ (AUTHOR), Martorana, Davide³ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Oct2024, Vol. 25 Issue 19, p10822. 18p.

A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia.

Autor: Lang F; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany. fabian.lang@kgu.de., Wunderle L; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Badura S; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Schleyer E; Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, Leipzig University Hospital, Leipzig, Germany., Brüggemann M; Department of Hematology, UKSH, Campus Kiel, Kiel, Germany., Serve H; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany.; DKFZ Heidelberg, Heidelberg, Germany., Schnittger S; Münchner Leukämie Labor, Munich, Germany., Gökbuget N; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Pfeifer H; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Wagner S; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Ashelford K; School of Medicine, Cardiff University, Cardiff, Wales, UK., Bug G; Department of Medicine, Hematology and Oncology, Goethe University Hospital, Frankfurt, Germany., Ottmann OG; School of Medicine, Cardiff University, Cardiff, Wales, UK.

Publikováno v: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2020 Sep 29; Vol. 21 (1), pp. 70. Date of Electronic Publication: 2020 Sep 29.

109 - Investigating the impact of telomere dysfunction on the cancer genome

Autor: Escudero, L., Fegan, C., Pepper, C., Ashelford, K., Norris, K., Cleal, K., Liddiard, K., Baird, D.M.

Publikováno v: In European Journal of Cancer July 2016 61 Supplement 1:S11-S11