Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Asheebo Rojas"'
Autor:
Varun Rawat, Avijit Banik, Radhika Amaradhi, Asheebo Rojas, Shashidharamurthy Taval, Tamas Nagy, Raymond Dingledine, Thota Ganesh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 147, Iss , Pp 112646- (2022)
The EP2 receptor has emerged as a therapeutic target with exacerbating role in disease pathology for a variety of peripheral and central nervous system disorders. We and others have recently demonstrated beneficial effects of EP2 antagonists in precl
Externí odkaz:
https://doaj.org/article/42f70df4e51b4220ae6a61c9a4784d77
Publikováno v:
Neurobiology of Disease, Vol 140, Iss , Pp 104863- (2020)
Seizures can be evident within minutes of exposure to an organophosphorus (OP) agent and often progress to status epilepticus (SE) resulting in a high mortality if left untreated. Effective medical countermeasures are necessary to sustain patients su
Externí odkaz:
https://doaj.org/article/207217eab3a74129a9106833b6d1039b
Publikováno v:
Neurobiology of Disease, Vol 133, Iss , Pp - (2020)
This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2
Externí odkaz:
https://doaj.org/article/9bf417baf60e45f2a228193172e4da9a
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 74-89 (2014)
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study. Here we demonstrate that the prostaglandin E2 r
Externí odkaz:
https://doaj.org/article/e3ab6c6966364dd2af2601d713dea8d0
Publikováno v:
NeuroToxicology. 91:45-59
Exposure to high levels of a cholinesterase inhibiting organophosphorus (OP) agent often results in seizures that progress to status epilepticus (SE). Survivors of OP-induced SE often display neuropathological consequences the days following SE. In t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9d515835214136856055c1e83f21a5
https://doi.org/10.1016/j.neuro.2022.04.010
https://doi.org/10.1016/j.neuro.2022.04.010
Autor:
Thota Ganesh, Avijit Banik, Asheebo Rojas, Damoder Reddy Motati, Raymond Dingledine, Shabber Mohammed, Wenyi Wang, Radhika Amaradhi, Vidyavathi Patro
Publikováno v:
J Med Chem
Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathology in central nervous system diseases such as epilepsy, Alzheimer's disease, and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1db3d0b0dccdda8e821c69f53ae2ab
https://doi.org/10.1021/acs.jmedchem.9b01218
https://doi.org/10.1021/acs.jmedchem.9b01218
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12531, p 12531 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Sleep disturbances, such as insomnia, obstructive sleep apnea, and daytime sleepiness, are common in people diagnosed with epilepsy. These disturbances can be attributed to nocturnal seizures, psychosocial factors, and/or the use of anti-epileptic dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee992ae85e03e5ca612cdbcaa339cc87
https://www.mdpi.com/1422-0067/22/22/12531
https://www.mdpi.com/1422-0067/22/22/12531
Publikováno v:
Expert Opinion on Therapeutic Targets. 23:1-13
Introduction：A robust neuroinflammatory response is a prevalent feature of multiple neurological disorders, including epilepsy and acute status epilepticus. One component of this neuroinflammatory reaction is the induction of cyclooxygenase-2 (COX-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f115747f7b8a51faeee49fc2b7572d9
https://doi.org/10.1080/14728222.2019.1554056
https://doi.org/10.1080/14728222.2019.1554056
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 4061, p 4061 (2021)
International Journal of Molecular Sciences, Vol 22, Iss 4061, p 4061 (2021)
Epilepsy, one of the most common neurological disorders worldwide, is characterized by recurrent seizures and subsequent brain damage. Despite strong evidence supporting a deleterious impact on seizure occurrence and outcome severity, stress is an ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b1c0e3076c934259183b7a09d93e8
http://europepmc.org/articles/PMC8071059
http://europepmc.org/articles/PMC8071059
Autor:
Jennifer Wang, Wenyi Wang, JuanMartin Abreu-Melon, Raymond Dingledine, Asheebo Rojas, John H. McDonough, Hilary S. McCarren, Sarah Wang
Publikováno v:
Neurotoxicology
The increasing number of cases involving the use of nerve agents as deadly weapons has spurred investigation into the molecular mechanisms underlying nerve agent-induced pathology. The highly toxic nature of nerve agents restrict their use in academi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8078073dd8062b60428002557fbbacac
https://europepmc.org/articles/PMC7987879/
https://europepmc.org/articles/PMC7987879/
