Increased 4E-BP1 Expression Protects against Diet-Induced Obesity and Insulin Resistance in Male Mice.

Autor: Tsai SY; Buck Institute for Research on Aging, Novato, CA 94945, USA., Rodriguez AA; Buck Institute for Research on Aging, Novato, CA 94945, USA., Dastidar SG; Division of Biological Sciences, Departments of Pediatrics, Cellular and Molecular Medicine, and Neurosciences, Institute for Genomic Medicine, and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92903, USA., Del Greco E; Buck Institute for Research on Aging, Novato, CA 94945, USA., Carr KL; Buck Institute for Research on Aging, Novato, CA 94945, USA., Sitzmann JM; Buck Institute for Research on Aging, Novato, CA 94945, USA., Academia EC; Buck Institute for Research on Aging, Novato, CA 94945, USA., Viray CM; Buck Institute for Research on Aging, Novato, CA 94945, USA., Martinez LL; Buck Institute for Research on Aging, Novato, CA 94945, USA., Kaplowitz BS; Buck Institute for Research on Aging, Novato, CA 94945, USA., Ashe TD; Division of Biological Sciences, Departments of Pediatrics, Cellular and Molecular Medicine, and Neurosciences, Institute for Genomic Medicine, and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92903, USA., La Spada AR; Division of Biological Sciences, Departments of Pediatrics, Cellular and Molecular Medicine, and Neurosciences, Institute for Genomic Medicine, and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92903, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address: alaspada@ucsd.edu., Kennedy BK; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: bkennedy@buckinstitute.org.

Publikováno v: Cell reports [Cell Rep] 2016 Aug 16; Vol. 16 (7), pp. 1903-14. Date of Electronic Publication: 2016 Aug 04.

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

Autor: Dubinsky AN; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Dastidar SG; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Hsu CL; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Zahra R; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Djakovic SN; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Duarte S; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal., Esau CC; Regulus Therapeutics, 3545 John Hopkins Court, Suite 210, San Diego, CA 92121, USA., Spencer B; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Ashe TD; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., Fischer KM; Regulus Therapeutics, 3545 John Hopkins Court, Suite 210, San Diego, CA 92121, USA., MacKenna DA; Regulus Therapeutics, 3545 John Hopkins Court, Suite 210, San Diego, CA 92121, USA., Sopher BL; Department of Neurology, University of Washington, Seattle, WA 98195, USA., Masliah E; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA., Gaasterland T; Scripps Institute for Oceanography, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA., Chau BN; Regulus Therapeutics, 3545 John Hopkins Court, Suite 210, San Diego, CA 92121, USA., Pereira de Almeida L; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517 Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal., Morrison BE; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA., La Spada AR; Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address: alaspada@ucsd.edu.

Publikováno v: Cell metabolism [Cell Metab] 2014 Oct 07; Vol. 20 (4), pp. 626-38.