Zobrazeno 1 - 10
of 625
pro vyhledávání: '"Ashcroft FM"'
Publikováno v:
Laboratory Animals
Since it was introduced 20 years ago, tamoxifen-inducible genetic recombination in vivo has become a standard tool in many fields. This technique has great utility, allowing precise temporal and spatial gene recombination mediated by expression of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f60e07425b511a82acf0cf596be93082
https://doi.org/10.1177/0023677219856918
https://doi.org/10.1177/0023677219856918
Autor:
Knudsen, JG, Hamilton, A, Ramracheya, R, Tarasov, AI, Brereton, M, Haythorne, E, Chibalina, MV, Spégel, P, Mulder, H, Zhang, Q, Ashcroft, FM, Adam, J, Rorsman, P
Publikováno v:
Cell Metabolism
Summary Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to th
Autor:
Ashcroft, FM, Gribble, FM
Sulfonylureas stimulate insulin secretion in type-2 diabetic patients by blocking ATP-sensitive (K(ATP)) potassium channels in the pancreatic beta-cell membrane. This effect is mediated by the binding of the drug to the sulfonylurea receptor (SUR) su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6ec2cd3ab9470bf38745719edd2cb4ff
https://ora.ox.ac.uk/objects/uuid:a77d2707-e8fe-448d-b617-de0beaed4a97
https://ora.ox.ac.uk/objects/uuid:a77d2707-e8fe-448d-b617-de0beaed4a97
In this study, we tested the effects of the stilbene disulphonates DIDS and SITS on three different types of cloned K(ATP) channel (Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2DeltaC) heterologously expressed in Xenopus oocytes, with the aim of identifying t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a219afc8817eb37872210f93f4d8e8ae
https://ora.ox.ac.uk/objects/uuid:a21d2d72-2969-4cd6-b4c5-05f22b16493b
https://ora.ox.ac.uk/objects/uuid:a21d2d72-2969-4cd6-b4c5-05f22b16493b