Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination

Autor: Brambilla, Roberta, Morton, Paul D., Ashbaugh, Jessica Jopek, Karmally, Shaffiat, Lambertsen, Kate Lykke, Bethea, John R.

Publikováno v: Brambilla, R, Morton, P D, Ashbaugh, J J, Karmally, S, Lambertsen, K L & Bethea, J R 2014, ' Astrocytes play a key role in EAE pathophysiology by orchestrating in the CNS the inflammatory response of resident and peripheral immune cells and by suppressing remyelination ', Glia, vol. 62, no. 3, pp. 452-467 . https://doi.org/10.1002/glia.22616

Astrocytes respond to insult with a process of cellular activation known as reactive astrogliosis. One of the key signals regulating this phenomenon is the transcription factor nuclear factor-kappa B (NF-κB), which is responsible for modulating infl

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https://portal.findresearcher.sdu.dk/da/publications/3243d6ae-4645-499a-bb7e-b4e842f3ee58

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