Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ashan Manhas"'
Autor:
Vinay Shankar Tiwari, Prince Joshi, Kanchan Yadav, Anamika Sharma, Sushobhan Chowdhury, Ashan Manhas, Niti Kumar, Renu Tripathi, Wahajul Haq
Publikováno v:
ACS Omega, Vol 6, Iss 20, Pp 12984-12994 (2021)
Externí odkaz:
https://doaj.org/article/4b06e4d5f42645c7acffd8bec9ae993a
Autor:
Nitin H. Andhare, Mohammad Anas, Sumit K. Rastogi, Ashan Manhas, Yogesh Thopate, Kumkum Srivastava, Niti Kumar, Arun K. Sinha
In pursuit of antimalarial drug, to overcome the drug resistance and the risk of drug-drug interactions, the chalcone hybrids and their structure-activity relationship for the antimalarial activity studied against chloroquine sensitive as well as mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c13b0590fbecf3c5dde4c33dfcf41c1
https://doi.org/10.21203/rs.3.rs-1522845/v1
https://doi.org/10.21203/rs.3.rs-1522845/v1
Autor:
Jais Kurian, Muraleedharan K. Manheri, Ashan Manhas, Ramshad Kalluruttimmal, Mohammad Anas, Saheer V. Chaluvalappil, Varsha Kumari, Niti Kumar
Publikováno v:
ChemMedChem. 17(2)
Although many quinolones have shown promise as potent antimalarials, their clinical development has been slow due to poor performance in vivo. Insights into structural modifications that can improve their therapeutic potential will be very valuable i
Autor:
Anamika Sharma, Ashan Manhas, Renu Tripathi, Prince Joshi, Vinay Shankar Tiwari, Wahajul Haq, Sushobhan Chowdhury, Niti Kumar, Kanchan Yadav
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 20, Pp 12984-12994 (2021)
ACS Omega, Vol 6, Iss 20, Pp 12984-12994 (2021)
A series of novel 4-aminoquinoline analogues bearing a methyl group at 4-aminoquinoline moiety were synthesized via a new and robust synthetic route comprising in situ tert-butoxycarbonyl (Boc) deprotection-methylation cascade resulting in the corres
Autor:
Ravindra Shukla, Naveen K. Sharma, Niti Kumar, Kumkum Srivastava, Manish Kumar Dwivedi, Ashan Manhas, Prashant Singh
Publikováno v:
Journal of ethnopharmacology. 275
Ethanopharmacological relevance Limited drugs, rise in drug resistance against frontline anti-malarial drugs, non-availability of efficacious vaccines and high cost of drug development hinders malaria intervention programs. Search for safe, effective
Publikováno v:
Bioorganic Chemistry. 121:105671
In our efforts to identify novel chemical scaffolds for the development of antimalarial agents, a series of quinoline - imidazole hybrid compounds were synthesized and their blood-stage antimalarial activity was evaluated in both drug-sensitive and -
Autor:
Srinivasarao Kondaparla, Seturam B. Katti, Vasantha Rao Dola, Kumkum Srivastava, Ashan Manhas, Sunil K. Puri
Publikováno v:
Bioorganic Chemistry. 80:204-211
A series of short chain 4-aminoquinoline-imidazole derivatives have been synthesized in one pot two step multicomponent reaction using van leusen standard protocol. The diethylamine function of chloroquine is replaced by substituted imidazole derivat
Autor:
Richa Sharma, Pushpangadan Indira Pradeepkumar, Ashan Manhas, Mohammad Anas, Niti Kumar, V. Dhamodharan, Kumkum Srivastava, Shakil Ahmed
Publikováno v:
Biochemistry. 56:6691-6699
The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in parasite survival, pathogenesis, and host immune evasion. An intriguing question is whether the
Autor:
Shiv Vardan Singh, Sonali Mishra, Ashan Manhas, Karuna Shanker, Anirban Pal, Yogesh Kumar, Kumkum Srivastava, Feroz Khan
Publikováno v:
Biomedicine & Pharmacotherapy. 89:761-771
A clinical emergency stands due to the appearance of drug resistant Plasmodium strains necessitate novel and effective antimalarial chemotypes, where plants seem as the prime option, especially after the discovery of quinine and artemisinin. The pres
Autor:
Kumkum Srivastava, Srinivasarao Kondaparla, Ashan Manhas, Awakash Soni, Seturam B. Katti, Sunil K. Puri
Publikováno v:
RSC Advances. 6:105676-105689
In the present study we have synthesized a new class of 4-aminoquinoline derivatives via replacement of the diethylamine functionality of chloroquine (CQ) with acyclic and/or cyclic amine groups containing basic tertiary terminal nitrogen and bioeval