Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Asha S. Nayar"'
Autor:
Robert E. McLaughlin, Elise Gorseth, Michael T. Rooney, Ann E. Eakin, Aryun Kim, Asha S. Nayar, Andy S. Tsai, Kerry E. Murphy-Benenato, Alita A. Miller, Jared L. Crandon, David P. Nicolau, Christina M. Blinn, April Chen, David E. Ehmann, Amy Kutschke, Brian Dangel, Sara A. Patey
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:7743-7752
The objective of this study was to investigate the risk of attenuated efficacy due to adaptive resistance for the siderophore-conjugated monocarbam SMC-3176 in Pseudomonas aeruginosa by using a pharmacokinetic/pharmacodynamic (PK/PD) approach. MICs w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34771f5a04a33c3d3142e2a0d2b73c23
https://doi.org/10.1128/aac.00831-15
https://doi.org/10.1128/aac.00831-15
Autor:
Sharon Tentarelli, Camil Joubran, Alita A. Miller, Ying Zhou, Vincent M. Isabella, Lakshmi E. Miller-Vedam, Asha S. Nayar
Publikováno v:
Analytical Chemistry. 87:3579-3584
Significant challenges are present in antibiotic drug discovery and development. One of these is the number of efficient approaches Gram-negative bacteria have developed to avoid intracellular accumulation of drugs and other cell-toxic species. In or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff05818c7392eabb816f2ca16b5e6b60
https://doi.org/10.1021/ac504880r
https://doi.org/10.1021/ac504880r
Autor:
David E. Ehmann, Jason Thresher, Asha S. Nayar, Ning Gao, Folkert Reck, Adam B. Shapiro, Thomas J. Dougherty
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:331-337
In a previous report (T. J. Dougherty, A. Nayar, J. V. Newman, S. Hopkins, G. G. Stone, M. Johnstone, A. B. Shapiro, M. Cronin, F. Reck, and D. E. Ehmann, Antimicrob Agents Chemother 58:2657–2664, 2014), a novel bacterial type II topoisomerase inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2632fda9d5d600daf271f08bf6541e
https://doi.org/10.1128/aac.04077-14
https://doi.org/10.1128/aac.04077-14
Publikováno v:
Microbiology (Reading, England). 153(Pt 2)
Anabaena sp. strain PCC 7120 is a filamentous cyanobacterium that differentiates nitrogen-fixing heterocysts when fixed nitrogen becomes growth limiting in the medium. The gene alr2338 (designated fraG herein), located immediately upstream of the mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74551774011aad4fa9e38b2a316600ff
https://pubmed.ncbi.nlm.nih.gov/17259632
https://pubmed.ncbi.nlm.nih.gov/17259632
Autor:
Sussie Hopkins, David E. Ehmann, Mark Cronin, Folkert Reck, Adam B. Shapiro, Gregory G. Stone, Thomas J. Dougherty, Michele Johnstone, Asha S. Nayar, Joseph V. Newman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4250-4250
The need for new antibiotics that address serious Gram-negative infections is well recognized. Our efforts with a series of novel bacterial type II topoisomerase inhibitors (NBTIs) led to the discovery of NBTI 5463, an agent with improved activity ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829bfe485432453cf2decbbd2eadd02c
https://doi.org/10.1128/aac.03222-14
https://doi.org/10.1128/aac.03222-14
Autor:
Mark Sylvester, Tommasi Ruben A, Arthur Campbell, Vincent M. Isabella, Alita A. Miller, Asha S. Nayar, John I. Manchester, Keith E. Ferguson
Publikováno v:
Chemistry & Biology. (4):535-547
SummaryUnderstanding how compound penetration occurs across the complex cell walls of Gram-negative bacteria is one of the greatest challenges in discovering new drugs to treat the infections they cause. A combination of next-generation transposon se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c48739d1918fd253cb46472ddb4016