Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Asha Hewarathna"'
Screening of Polysorbate-80 Composition by High Resolution Mass Spectrometry with Rapid H/D Exchange
Autor:
Asha Hewarathna, Ilan Geerlof-Vidavsky, Kui Yang, V. Ashutosh Rao, Connie M Gryniewicz-Ruzicka, David A. Keire
Publikováno v:
Analytical Chemistry. 91:14649-14656
Polysorbate (PS) is a widely used polymeric excipient in biotherapeutic formulations to stabilize and protect protein drugs. Commercial PS is a highly heterogeneous mixture of structurally related components. PS composition can impact the stabilizer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52f951515e589c66020d6cd82ad33ff
https://doi.org/10.1021/acs.analchem.9b03809
https://doi.org/10.1021/acs.analchem.9b03809
Autor:
Jian Xiong, Peter A. Kleindl, C. Russell Middaugh, M. Laird Forrest, David B. Volkin, Christian Schöneich, Eric J. Deeds, Maulik K. Nariya, Asha Hewarathna, Sangeeta B. Joshi, Olivier Mozziconacci, Adam C. Fisher
Publikováno v:
Journal of Pharmaceutical Sciences. 106:3257-3269
As the second of a 3-part series of articles in this issue concerning the development of a mathematical model for comparative characterization of complex mixture drugs using crofelemer (CF) as a model compound, this work focuses on the evaluation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23be0636baa516dc5c22b136b6e144a4
https://doi.org/10.1016/j.xphs.2017.06.022
https://doi.org/10.1016/j.xphs.2017.06.022
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1865:121-131
An interaction of Bcl-2 with SERCA had been documented in vitro using the SERCA1a isoform isolated from rat skeletal muscle [Dremina, E. S., Sharov, V. S., Kumar, K., Azidi, A., Michaelis, E. K., Schoneich, C. (2004) Biochem. J. 383 (361–370)]. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::762eaec96c3772979a82d77b64971ef7
https://doi.org/10.1016/j.bbapap.2016.09.004
https://doi.org/10.1016/j.bbapap.2016.09.004
Autor:
M. Laird Forrest, Maulik K. Nariya, Sangeeta B. Joshi, Peter A. Kleindl, Jian Xiong, Eric J. Deeds, Christian Schöneich, David B. Volkin, Adam C. Fisher, Asha Hewarathna, C. Russell Middaugh, Jae Hyun Kim
Publikováno v:
Journal of pharmaceutical sciences. 106(11)
There is growing interest in generating physicochemical and biological analytical data sets to compare complex mixture drugs, for example, products from different manufacturers. In this work, we compare various crofelemer samples prepared from a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74c7cb50fbb445cde4fd44c4187c3b8
https://pubmed.ncbi.nlm.nih.gov/28743607
https://pubmed.ncbi.nlm.nih.gov/28743607
Autor:
David B. Volkin, Peter A. Kleindl, C. Russell Middaugh, Christian Schöneich, Adam C. Fisher, Jian Xiong, Maulik K. Nariya, Eric J. Deeds, Olivier Mozziconacci, Sangeeta B. Joshi, M. Laird Forrest, Asha Hewarathna
Publikováno v:
Journal of pharmaceutical sciences. 106(11)
Crofelemer is a botanical polymeric proanthocyanidin that inhibits chloride channel activity and is used clinically for treating HIV-associated secretory diarrhea. Crofelemer lots may exhibit significant physicochemical variation due to the natural s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb7a350811e7aa5d62dd86422041f03
https://pubmed.ncbi.nlm.nih.gov/28743606
https://pubmed.ncbi.nlm.nih.gov/28743606
Publikováno v:
Free Radical Biology and Medicine. 108:S73
Bcl-2 is an anti-apoptotic protein, which is involved in the interaction with multiple proteins at various cellular locations, including mitochondria and the ER. We show here, that Bcl-2 interacts efficiently with various isoforms of the sarco/endopl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b5bb0a279451e0fa1904f560026bd3
https://doi.org/10.1016/j.freeradbiomed.2017.04.248
https://doi.org/10.1016/j.freeradbiomed.2017.04.248
Publikováno v:
Free Radical Biology and Medicine. 108:S100
Alzheimer's disease (AD) represents a neurodegenerative disease leading to progressive dementia in the elderly. AD has been associated with increased oxidative stress and mitochondrial dysfunction. Hence, markers for oxidative stress are expected to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea078f5753008c4bf17d950ab4862619
https://doi.org/10.1016/j.freeradbiomed.2017.04.321
https://doi.org/10.1016/j.freeradbiomed.2017.04.321