On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons

Autor: Toshiaki Shigeoka, Max Koppers, Hovy Ho-Wai Wong, Julie Qiaojin Lin, Roberta Cagnetta, Asha Dwivedy, Janaina de Freitas Nascimento, Francesca W. van Tartwijk, Florian Ströhl, Jean-Michel Cioni, Julia Schaeffer, Mark Carrington, Clemens F. Kaminski, Hosung Jung, William A. Harris, Christine E. Holt

Publikováno v: Cell Reports, Vol 29, Iss 11, Pp 3605-3619.e10 (2019)

Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Here, we report a physical and

Externí odkaz: https://doaj.org/article/03a40e7b28d94e35809090a5ff021644

ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis

Autor: Filip A. Konopacki, Hovy Ho-Wai Wong, Asha Dwivedy, Anaïs Bellon, Michael D. Blower, Christine E. Holt

Publikováno v: Open Biology, Vol 6, Iss 4 (2016)

Endocytosis and local protein synthesis (LPS) act coordinately to mediate the chemotropic responses of axons, but the link between these two processes is poorly understood. The endosomal sorting complex required for transport (ESCRT) is a key regulat

Externí odkaz: https://doaj.org/article/b840736eec2a474caf211487ad2bb95c

Author response: Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

Autor: Christine E. Holt, John G. Flanagan, William A. Harris, Maximilian Ah Jakobs, Max Koppers, Anaïs Bellon, Julie Qiaojin Lin, Roberta Cagnetta, Clemens F. Kaminski, Michael S Minett, Toshiaki Shigeoka, Lucia C. S. Wunderlich, Sixian Zhao, Asha Dwivedy, Pedro Vallejo-Ramirez

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71400fc8020d30dd4db03dacbdc3568e
https://doi.org/10.7554/elife.48718.sa2

On-site ribosome remodeling by locally synthesized ribosomal proteins in axons

Autor: Christine E. Holt, Asha Dwivedy, Florian Ströhl, Roberta Cagnetta, Max Koppers, Francesca W. van Tartwijk, Mark Carrington, Hovy Ho-Wai Wong, Jean-Michel Cioni, Clemens F. Kaminski, Toshiaki Shigeoka, Hosung Jung, Janaina de Freitas Nascimento, William A. Harris, Julie Qiaojin Lin

SUMMARYRibosomes are known to be assembled in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding ribosomal proteins (RPs) in axons, far away from neuronal cell bodies. Using subcellular proteomics and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891270dc72b32d786d426156ce866cd7

Mechanosensing is critical for axon growth in the developing brain

Autor: Luciano da Fontoura Costa, Graham K. Sheridan, Christine E. Holt, Eva K Pillai, Sarah Foster, David E. Koser, Hanno Svoboda, Kristian Franze, Amelia J Thompson, Jochen Guck, Matheus P. Viana, Asha Dwivedy

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature neuroscience

During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling. However, growing neurons interact not only chemically but also mechanically with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2573de51d0af8402bcedfb091ef42b85