Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Asha, Recino"'
Autor:
Robert A. Benson, Fabien Garcon, Asha Recino, John R. Ferdinand, Menna R. Clatworthy, Herman Waldmann, James M. Brewer, Klaus Okkenhaug, Anne Cooke, Paul Garside, Maja Wållberg
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
We present a novel and readily accessible method facilitating cellular time-resolved imaging of transplanted pancreatic islets. Grafting of islets to the mouse ear pinna allows non-invasive, in vivo longitudinal imaging of events in the islets and en
Externí odkaz:
https://doaj.org/article/96636762e3204d01b5265dcbd95c7c77
Autor:
Ariana Barbera Betancourt, Juliet L Emery, Asha Recino, F Susan Wong, Anne Cooke, Klaus Okkenhaug, Maja Wallberg
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146516 (2016)
Type 1 diabetes is caused by the destruction of insulin producing beta cells by the immune system. The p110δ isoform of PI3K is expressed primarily in cells of haematopoietic origin and the catalytic activity of p110δ is important for the activatio
Externí odkaz:
https://doaj.org/article/7b36e4f4e47e4e7ea1556bc362fd401d
Autor:
Asha Recino, Nick Holmes, Rob Foale, Shu Uin Gan, Fiona M. Gribble, Kian Chuan Sia, Yvonne Sawyer, Anne Cooke, Maja Wallberg, Roy Y Calne, Kok Onn Lee, Frank Reimann, Amit C. Nathwani, Jenny Trendell, Maria Notaridou, Richard Kay, Andrew M. L. Lever
Publikováno v:
Gene Therapy
We report the restoration of euglycaemia in chemically induced diabetic C57BL/6 mice and spontaneously diabetic Non Obese Diabetic (NOD) mice by intravenous systemic administration of a single-stranded adeno-associated virus (ssAAV2/8) codon optimise
Autor:
Nick Holmes, Dan Holmberg, Kerry Barkan, Asha Recino, Julia Nilsson, Graham Ladds, Anne Cooke, Luca Laraia, Anja Schmidt-Christensen, David R. Spring, Jacob Hecksher-Sørensen, Maja Wallberg, Duncan Howie, Larsson P, Malin Flodström-Tullberg
Glucagon-like peptide 1 (GLP-1) is produced by L cells in the small intestine in response to ingested glucose and increases insulin release from pancreatic beta cells by activation of its cognate receptor (GLP-1R). Stimulation of this receptor also c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d385d3b883ab5ea774b7d132a33a9269
Autor:
Nelson Fernandez, Christopher E. Rudd, Asha Recino, Youg Raj Thaker, Asma Jabeen, Maja Wallberg, Monika Raab
Publikováno v:
The Journal of Biological Chemistry
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 ha
Autor:
Pratigya Gautam, Asha Recino, Roy Y. Calne, Shu Uin Gan, Maja Wallberg, Andrew M. L. Lever, Jing Zhao, Robert D. Foale
Publikováno v:
The Journal of Gene Medicine. 18:312-321
Background The lack of an ideal cell type that can be easily acquired, modified to produce insulin, and re-implanted has been a limitation for ex vivo insulin gene therapy. Canine diabetes is currently treated with human insulin and is a good model f
Publikováno v:
Bioscience Reports
Metabolism is of central importance for T cell survival and differentiation. It is well known that T cells cannot function in the absence of glucose, but it is less clear how they respond to excessive levels of glucose. In the present study, we inves
Autor:
Maja Wallberg, Amit C. Nathwani, Sir Roy Calne, Rob Foale, Asha Recino, Ko Lee, Shu Uin Gan, Andrew M. L. Lever
Publikováno v:
BSAVA Congress Proceedings 2017 ISBN: 9781910443422
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2307ae65b5701cd02a38c9295e59e39e
https://doi.org/10.22233/9781910443439.61.5
https://doi.org/10.22233/9781910443439.61.5
Autor:
Christopher Paluch, Miyuki Azuma, Margaux Vienne, Anne Cooke, Asha Recino, Jenny M. Phillips, Florence Susan Wong, Maja Wallberg, Herman Waldmann, Duncan Howie
Publikováno v:
Immunology
Summary T cells play a key role in the pathogenesis of type 1 diabetes, and targeting the CD3 component of the T‐cell receptor complex provides one therapeutic approach. Anti‐CD3 treatment can reverse overt disease in spontaneously diabetic non
Autor:
Anne Cooke, Ariana Barbera Betancourt, Klaus Okkenhaug, Juliet L. Emery, Maja Wallberg, Asha Recino, F. Susan Wong
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146516 (2016)
PLoS ONE, Vol 11, Iss 1, p e0146516 (2016)
Type 1 diabetes is caused by the destruction of insulin producing beta cells by the immune system. The p110δ isoform of PI3K is expressed primarily in cells of haematopoietic origin and the catalytic activity of p110δ is important for the activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ea22c76e9de01919ef98203feb3882
https://www.repository.cam.ac.uk/handle/1810/253733
https://www.repository.cam.ac.uk/handle/1810/253733