Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Asger Wretlind"'
Autor:
Asger Wretlind, Viktor Rotbain Curovic, Andressa de Zawadzki, Tommi Suvitaival, Jin Xu, Emilie Hein Zobel, Bernt Johan von Scholten, Rasmus Sejersten Ripa, Andreas Kjaer, Tine Willum Hansen, Tina Vilsbøll, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Specific ceramides have been identified as risk markers for cardiovascular disease (CVD) years before onset of disease. Treatment with the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide has been shown to induce ben
Externí odkaz:
https://doaj.org/article/81dad782fa1040f5abe1e046c103c5d3
Autor:
Roderick C. Slieker, Louise A. Donnelly, Elina Akalestou, Livia Lopez-Noriega, Rana Melhem, Ayşim Güneş, Frederic Abou Azar, Alexander Efanov, Eleni Georgiadou, Hermine Muniangi-Muhitu, Mahsa Sheikh, Giuseppe N. Giordano, Mikael Åkerlund, Emma Ahlqvist, Ashfaq Ali, Karina Banasik, Søren Brunak, Marko Barovic, Gerard A. Bouland, Frédéric Burdet, Mickaël Canouil, Iulian Dragan, Petra J. M. Elders, Celine Fernandez, Andreas Festa, Hugo Fitipaldi, Phillippe Froguel, Valborg Gudmundsdottir, Vilmundur Gudnason, Mathias J. Gerl, Amber A. van der Heijden, Lori L. Jennings, Michael K. Hansen, Min Kim, Isabelle Leclerc, Christian Klose, Dmitry Kuznetsov, Dina Mansour Aly, Florence Mehl, Diana Marek, Olle Melander, Anne Niknejad, Filip Ottosson, Imre Pavo, Kevin Duffin, Samreen K. Syed, Janice L. Shaw, Over Cabrera, Timothy J. Pullen, Kai Simons, Michele Solimena, Tommi Suvitaival, Asger Wretlind, Peter Rossing, Valeriya Lyssenko, Cristina Legido Quigley, Leif Groop, Bernard Thorens, Paul W. Franks, Gareth E. Lim, Jennifer Estall, Mark Ibberson, Joline W. J. Beulens, Leen M ’t Hart, Ewan R. Pearson, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract We identify biomarkers for disease progression in three type 2 diabetes cohorts encompassing 2,973 individuals across three molecular classes, metabolites, lipids and proteins. Homocitrulline, isoleucine and 2-aminoadipic acid, eight triacyl
Externí odkaz:
https://doaj.org/article/8eb84b4a486246dfb262ac9be25f0911
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell f
Externí odkaz:
https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e
Autor:
Asger Wretlind, Emilie Hein Zobel, Andressa de Zawadzki, Rasmus Sejersten Ripa, Viktor Rotbain Curovic, Bernt Johan von Scholten, Ismo Matias Mattila, Tine Willum Hansen, Andreas Kjær, Henrik Vestergaard, Peter Rossing, Cristina Legido-Quigley
Publikováno v:
Frontiers in Clinical Diabetes and Healthcare, Vol 3 (2022)
BackgroundLiraglutide is a glucose-lowering medication used to treat type 2 diabetes and obesity. It is a GLP-1 receptor agonist with downstream metabolic changes beyond the incretin system, such as reducing the risk of cardiovascular complications.
Externí odkaz:
https://doaj.org/article/9a83d2ed45e7427bba080f2aa328deb5
Autor:
Jin Xu, Giulia Bankov, Min Kim, Asger Wretlind, Jodie Lord, Rebecca Green, Angela Hodges, Abdul Hye, Dag Aarsland, Latha Velayudhan, Richard J. B. Dobson, Petroula Proitsi, Cristina Legido-Quigley, on behalf of the AddNeuroMed Consortium
Publikováno v:
Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-15 (2020)
Abstract Background There is an urgent need to understand the pathways and processes underlying Alzheimer’s disease (AD) for early diagnosis and development of effective treatments. This study was aimed to investigate Alzheimer’s dementia using a
Externí odkaz:
https://doaj.org/article/a1ec73c16aeb4bf59bd98bb02e0536eb
Autor:
Andreas Kjær, Peter Rossing, Emilie H Zobel, Asger Wretlind, Rasmus S Ripa, Viktor Rotbain Curovic, Bernt J von Scholten, Tommi Suvitaival, Tine W Hansen, Cristina Legido-Quigley
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/cccfc22306d64967a2e1646bd7183cb0
Autor:
Andressa de Zawadzki, Maja Thiele, Tommi Suvitaival, Asger Wretlind, Min Kim, Mina Ali, Annette F. Bjerre, Karin Stahr, Ismo Mattila, Torben Hansen, Aleksander Krag, Cristina Legido-Quigley
Publikováno v:
Metabolites, Vol 12, Iss 3, p 211 (2022)
Feces are the product of our diets and have been linked to diseases of the gut, including Chron’s disease and metabolic diseases such as diabetes. For screening metabolites in heterogeneous samples such as feces, it is necessary to use fast and rep
Externí odkaz:
https://doaj.org/article/d216e48cb7884156878d17b3d73128b4
Autor:
Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/c286f4e96f8148e0ae12a0a2035467e5
Autor:
Alicia Gómez-Pascual, Talel Naccache, Jin Xu, Koroush Hooshmand, Asger Wretlind, Martina Gabrielli, Marta Tiffany Lombardo, Liu Shi, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Pop, Pablo Martinez-Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado-Holgado, Petroula Proitsi, Claudia Verderio, Juan A. Botía, Cristina Legido-Quigley
Mild Cognitive Impairment (MCI) is a phase that can precede Alzheimer's Disease (AD). To better understand the molecular mechanisms underlying conversion from MCI to AD, we proposed a multiomics machine learning pipeline (four algorithms) to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7029d5eb866c304ac63275859d5c15
https://doi.org/10.1101/2023.03.02.23286674
https://doi.org/10.1101/2023.03.02.23286674
Autor:
Liu Shi, Jin Xu, Rebecca Green, Asger Wretlind, Jan Homann, Noel J. Buckley, Betty M. Tijms, Stephanie J. B. Vos, Christina M. Lill, Mara ten Kate, Sebastiaan Engelborghs, Kristel Sleegers, Giovanni B. Frisoni, Anders Wallin, Alberto Lleó, Julius Popp, Pablo Martinez‐Lage, Johannes Streffer, Frederik Barkhof, Henrik Zetterberg, Pieter Jelle Visser, Simon Lovestone, Lars Bertram, Alejo J. Nevado‐Holgado, Petroula Proitsi, Cristina Legido‐Quigley
Publikováno v:
Alzheimer's & Dementia. Elsevier Science
Alzheimer's and Dementia. Elsevier
Shi, L, Xu, J, Green, R, Wretlind, A, Homann, J, Buckley, N J, Tijms, B M, Vos, S J B, Lill, C M, Kate, M T, Engelborghs, S, Sleegers, K, Frisoni, G B, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Streffer, J, Barkhof, F, Zetterberg, H, Visser, P J, Lovestone, S, Bertram, L, Nevado-Holgado, A J, Proitsi, P & Legido-Quigley, C 2023, ' Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12961
Alzheimer's & dementia
Alzheimer's and Dementia. Elsevier
Shi, L, Xu, J, Green, R, Wretlind, A, Homann, J, Buckley, N J, Tijms, B M, Vos, S J B, Lill, C M, Kate, M T, Engelborghs, S, Sleegers, K, Frisoni, G B, Wallin, A, Lleó, A, Popp, J, Martinez-Lage, P, Streffer, J, Barkhof, F, Zetterberg, H, Visser, P J, Lovestone, S, Bertram, L, Nevado-Holgado, A J, Proitsi, P & Legido-Quigley, C 2023, ' Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12961
Alzheimer's & dementia
IntroductionThis study employed an integrative system and causal inference approach to explore molecular signatures in blood and CSF, the amyloid/tau/neurodegeneration [AT(N)] framework, mild cognitive impairment (MCI) conversion to Alzheimer's disea