Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Asgar Hussain Ansari"'
Autor:
Sundaram Acharya, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan, Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, Rhythm Phutela, Sneha Gulati, Abdul Rahman, Arushi Goel, C. Afzal, Deepanjan Paul, Trupti Agrawal, Vinay Kumar Pulimamidi, Subhadra Jalali, Hiroshi Nishimasu, Indumathi Mariappan, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract The clinical success of CRISPR therapies hinges on the safety and efficacy of Cas proteins. The Cas9 from Francisella novicida (FnCas9) is highly precise, with a negligible affinity for mismatched substrates, but its low cellular targeting e
Externí odkaz:
https://doaj.org/article/967b3513bca24917a4d3b9306cf6ba0f
Autor:
Meghali Aich, Asgar Hussain Ansari, Li Ding, Vytautas Iesmantavicius, Deepanjan Paul, Chunaram Choudhary, Souvik Maiti, Frank Buchholz, Debojyoti Chakraborty
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113177- (2023)
Summary: Embryonic stem cells (ESCs) can undergo lineage-specific differentiation, giving rise to different cell types that constitute an organism. Although roles of transcription factors and chromatin modifiers in these cells have been described, ho
Externí odkaz:
https://doaj.org/article/e474f254575642cfab7f110e3f4cb827
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 241-256 (2022)
The triple-helix structure at the 3′ end of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA, has been considered to be a target for modulating the oncogenic functions of MALAT1. This study examines the binding
Externí odkaz:
https://doaj.org/article/fe1f09b2321645b9af2489e0533c2795
Autor:
Arpita Ghosh, Nihar Ranjan, Liuwei Jiang, Asgar Hussain Ansari, Natalya Degyatoreva, Shivaksh Ahluwalia, Dev P. Arya, Souvik Maiti
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 685-698 (2022)
MicroRNAs (miRs) are a class of endogenously expressed non-coding RNAs that negatively regulate gene expression within cells and participate in maintaining cellular homeostasis. By targeting 3′ UTRs of target genes, individual miRs can control a wi
Externí odkaz:
https://doaj.org/article/f11477af4978492e919373d5809ad08a
Publikováno v:
Non-Coding RNA, Vol 6, Iss 2, p 21 (2020)
RNA editing is a post-transcriptional modification, which can provide tissue-specific functions not encoded in DNA. Adenosine-to-inosine is the predominant editing event and, along with cytosine-to-uracil changes, constitutes canonical editing. The r
Externí odkaz:
https://doaj.org/article/5e115cf517244fa8b384a42c8ec5b684
Autor:
Anchal Sharma, Asgar Hussain Ansari, Renu Kumari, Rajesh Pandey, Rakhshinda Rehman, Bharati Mehani, Binuja Varma, Bapu K. Desiraju, Ulaganathan Mabalirajan, Anurag Agrawal, Arijit Mukhopadhyay
Publikováno v:
F1000Research, Vol 5 (2017)
Somatic variation in DNA can cause cells to deviate from the preordained genomic path in both disease and healthy conditions. Here, using exome sequencing of paired tissue samples, we show that the normal human brain harbors somatic single base varia
Externí odkaz:
https://doaj.org/article/68de2454c7f943c5bfdc7451f23a0ae1
Autor:
Meghali Aich, Asgar Hussain Ansari, Li Ding, Vytautas Iesmantavicius, Deepanjan Paul, Chunaram Choudhary, Souvik Maiti, Frank Buchholz, Debojyoti Chakraborty
Embryonic stem (ES) cells retain the ability to undergo lineage-specific differentiation that can eventually give rise to different cell types that constitute an organism. Although stem cell specific biological networks of transcription factors and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edea0a104b2b7e46d264fd90996fe88c
https://doi.org/10.1101/2023.01.03.522557
https://doi.org/10.1101/2023.01.03.522557
Autor:
Jennifer Seematti Sundar, Yasmeen Khan, Souvik Maiti, Arpita Ghosh, Mary Krishna Ekka, Debojyoti Chakraborty, Asgar Hussain Ansari, Praveen Singh, Satyaprakash Pandey
Publikováno v:
Nucleic Acids Research
MALAT1, an abundant lncRNA specifically localized to nuclear speckles, regulates alternative-splicing (AS). The molecular basis of its role in AS remains poorly understood. Here, we report three conserved, thermodynamically stable, parallel RNA-G-qua
Nucleic acid detection and variant calling through CRISPR-based diagnostics (CRISPRDx) has facilitated clinical decision-making, particularly during the COVID-19 pandemic. This has been further accelerated through the discovery of newer and engineere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e020f01feaaf19f003e76035b4b8dac8
https://doi.org/10.1101/2022.02.17.479653
https://doi.org/10.1101/2022.02.17.479653
Publikováno v:
Molecular therapy. Nucleic acids. 30
The triple-helix structure at the 3' end of metastasis-associated lung adenocarcinoma transcript 1 (