Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Aseem Z Ansari"'
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243905 (2020)
Pyrrole-imidazole (Py-Im) polyamides are synthetic molecules that can be rationally designed to target specific DNA sequences to both disrupt and recruit transcriptional machinery. While in vitro binding has been extensively studied, in vivo effects
Externí odkaz:
https://doaj.org/article/e69207fc8c78448ca363229f849bd1bd
Publikováno v:
eLife, Vol 6 (2017)
How transcription factor dimerization impacts DNA-binding specificity is poorly understood. Guided by protein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs. DNA interactomes of 80 heterodimers and 22 homodimer
Externí odkaz:
https://doaj.org/article/b629da49c40c4623a690f6d7de039597
Autor:
Deborah Chasman, Yi‐Hsuan Ho, David B Berry, Corey M Nemec, Matthew E MacGilvray, James Hose, Anna E Merrill, M Violet Lee, Jessica L Will, Joshua J Coon, Aseem Z Ansari, Mark Craven, Audrey P Gasch
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 11, Pp 1-23 (2014)
Abstract Stressed cells coordinate a multi‐faceted response spanning many levels of physiology. Yet knowledge of the complete stress‐activated regulatory network as well as design principles for signal integration remains incomplete. We developed
Externí odkaz:
https://doaj.org/article/06b8235ccb524af8a37b83247b850aa4
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003839 (2013)
Despite the importance of maintaining redox homeostasis for cellular viability, how cells control redox balance globally is poorly understood. Here we provide new mechanistic insight into how the balance between reduced and oxidized electron carriers
Externí odkaz:
https://doaj.org/article/a0cb9c0de9b54cb39901c22118d0ea65
Autor:
Erika Shor, Christopher L Warren, Joshua Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H Gohard, Adrian I Yemm, Lev Borisov, James R Broach, Michael Weinreich, Conrad A Nieduszynski, Aseem Z Ansari, Catherine A Fox
Publikováno v:
PLoS Genetics, Vol 5, Iss 12, p e1000755 (2009)
The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is to recruit silent information re
Externí odkaz:
https://doaj.org/article/6789becc7c98478a9587243c67348fd3
Autor:
Tanja Mittag, Aseem Z. Ansari
Publikováno v:
Nature Structural & Molecular Biology. 28:543-545
A spectrum of high-risk leukemias is caused by recurrent chromosomal translocations that result in the expression of fusion proteins. In a recent article in Nature, it has been demonstrated that the oncogenic properties of one such fusion, NUP98–HO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2aecfec563a65473ef907e42f5aa4d32
https://doi.org/10.1038/s41594-021-00608-3
https://doi.org/10.1038/s41594-021-00608-3
Autor:
Gabriel Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi, Natasha Koussa, Raphael Pavani, William Nathan, Frida Belinky, Ashraf Mohammed, Marek Napierala, Karen Usdin, Aseem Z. Ansari, Sergei M. Mirkin, André Nussenzweig
SummaryGenomic double-stranded DNA (dsDNA) becomes single-stranded (ssDNA) during replication, transcription, and DNA repair. ssDNA is therefore believed to be transient, occurring in only a fraction of the genome at a given time, and variable amongs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d394f2929754d67eefbe2050b9f1e35
https://doi.org/10.1101/2022.01.19.476973
https://doi.org/10.1101/2022.01.19.476973
Autor:
Gabriel Matos-Rodrigues, Niek van Wietmarschen, Wei Wu, Veenu Tripathi, Natasha C. Koussa, Raphael Pavani, William J. Nathan, Elsa Callen, Frida Belinky, Ashraf Mohammed, Marek Napierala, Karen Usdin, Aseem Z. Ansari, Sergei M. Mirkin, André Nussenzweig
Publikováno v:
Molecular Cell. 82:3538-3552.e5
DNA becomes single stranded (ssDNA) during replication, transcription, and repair. Transiently formed ssDNA segments can adopt alternative conformations, including cruciforms, triplexes, and quadruplexes. To determine whether there are stable regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ceae70b571d8fffb5e32641eaad036c
https://doi.org/10.1016/j.molcel.2022.08.007
https://doi.org/10.1016/j.molcel.2022.08.007
Autor:
Corinna Hintermair, Yi-Hsuan Ho, Rajesh Kumar Kar, Corey M. Nemec, Asfa Ali, Sohail Akhtar, Aseem Z. Ansari, Dirk Eick, Audrey P. Gasch, Sandra C. Tseng, Kennedy J Ringelberg, Mohammad Faiz Ahmad, Amit Kumar Singh, Kirtimaan Syal
Publikováno v:
Nature chemical biology
Nat. Chem. Biol. 15, 123–131 (2019)
Nat. Chem. Biol. 15, 123–131 (2019)
Phosphorylation of the carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) governs stage-specific interactions with different cellular machines. The CTD consists of Y1S2P3T4S5P6S7 heptad repeats, and sequential phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3da070f3992ff743d322d43e1f969a
http://europepmc.org/articles/PMC6339578
http://europepmc.org/articles/PMC6339578
Autor:
Aseem Z. Ansari
Publikováno v:
Cell chemical biology. 28(2)
In their quest to disable androgen receptor variants that drive castration-resistant prostate cancer, Richters et al. (2020) have hit upon a selective inhibitor of a transcriptional kinase that enables full-length mRNA synthesis. Drugging this essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03792933f0c19d4884ef1b56684aab2
https://pubmed.ncbi.nlm.nih.gov/33086052
https://pubmed.ncbi.nlm.nih.gov/33086052